PDCD6 Antibody
Product Specs
Target Background
This calcium sensor plays a critical role in various cellular processes, including endoplasmic reticulum (ER)-Golgi vesicular transport, endosomal biogenesis, and membrane repair. It functions as an adaptor protein, bridging disparate proteins or stabilizing weak protein-protein interactions in response to calcium fluctuations. Calcium binding exposes a hydrophobic surface, facilitating interactions with diverse protein sets via three distinct hydrophobic pockets, ultimately leading to membrane translocation. Specifically, it's involved in ER-Golgi transport by promoting the interaction between PDCD6IP and TSG101, linking ESCRT-III and ESCRT-I complexes. In conjunction with PEF1, it acts as a calcium-dependent adaptor for the BCR (KLHL12) complex, regulating COPII coat size and thus influencing ER-Golgi transport. Upon cytosolic calcium increase, its heterodimer with PEF1 interacts with and bridges the BCR (KLHL12) complex and SEC31 (SEC31A or SEC31B), promoting SEC31 monoubiquitination and subsequent collagen export, essential for neural crest specification. It also regulates MCOLN1 distribution and function within the endosomal pathway, promotes TFG localization and polymerization at ER exit sites, and is crucial for T-cell receptor-, Fas-, and glucocorticoid-induced apoptosis. It may mediate calcium-regulated signals in the apoptotic pathway, potentially accelerating cell death by increasing caspase-3 activity via interaction with DAPK1, although its role in apoptosis may be indirect. Additionally, it may inhibit KDR/VEGFR2-dependent angiogenesis by inhibiting VEGF-induced Akt pathway phosphorylation. In HIV-1 infection, it indirectly inhibits viral production by modulating viral Gag expression and distribution. This isoform exhibits a lower calcium affinity compared to isoform 1.
Related Research:
- miR-20a upregulation by HPV16 E6 promotes growth by targeting PDCD6 in cervical carcinoma cells. PMID: 29710555
- The t(5;21)(p15;q22) translocation was identified using FISH and RNA-sequencing following initial observation of a del(21)(qq) deletion. PMID: 29672642
- ALG-2 binding to Scotin is strictly calcium-dependent, suggesting a role in calcium signaling. PMID: 17889823
- Targeting Requiem and Alg-2 increased maximum viable cell numbers and cumulative IVCD under fed-batch conditions. PMID: 20571937
- The Alg-2 binding site influences Sec31A retention kinetics at ER exit sites. PMID: 20834162
- ALG-2 interacts with the P-body component PATL1, co-localizing with PATL1 and DCP1A. PMID: 22437941
- ALG-2 attenuates COPII budding in vitro and stabilizes the Sec23/Sec31A complex. PMID: 24069399
- The crystal structure of the ALG-2/Sec31A peptide complex reveals peptide binding to Pocket 3 and ALG-2 recognition of two motifs on Sec31A. PMID: 25667979
- ALG-2 exhibits an anti-apoptotic function in HeLa cells by facilitating G2/M cell cycle progression. PMID: 19013425
- ALG-2 is upregulated in mesenchymal tumors. PMID: 19383317
- ALG-2/Sec31A interactions regulate p24 and p115 trafficking. PMID: 25006245
- ALG-2 regulates cytoskeletal rearrangement during cell polarization and migration in breast cancer. PMID: 27926525
- MAP1B heavy chain contains a unique ALG-2 binding site. PMID: 29432744
- Intracellular calcium levels regulate the secretory pathway via ALG-2 interactions with MISSL and MAP1B. PMID: 28864773
- ALG-2 and HEBP2 are upregulated in breast and lung cancer, influencing ALG-2 cytoplasmic localization and HEBP2 subcellular distribution, impacting spindle orientation. PMID: 28004381
- ALG-2 concentrates and polymerizes TFG at ER exit sites, suggesting a role in COPII-dependent trafficking. PMID: 27813252
- ALG-2 shows tumor suppressive activity in glioblastoma. PMID: 28300556
- miR-183 enhances cell proliferation by targeting PDCD6. PMID: 27738758
- The rs3756712 polymorphism is associated with endometriosis risk. PMID: 27546697
- PDCD6 plays a role in cervical squamous cell carcinoma pathogenesis. PMID: 25362542
- PDCD6 may be a biomarker for gastric cancer recurrence and mortality. PMID: 24792888
- Palmitoylation sites and the N-terminal Pro-rich region are necessary for efficient secretion; ALG-2 binding sites are dispensable. PMID: 23350699
- PDCD6 polymorphisms are associated with uterine leiomyoma risk. PMID: 23551056
- CHERP and ALG-2 regulate alternative splicing of IP3R1 pre-mRNA. PMID: 24078636
- ALG-2 binding to IST1 is calcium-dependent. PMID: 23649269
- PDCD6 is a susceptibility gene for endometriosis. PMID: 23137875
- The rs4957014G/T polymorphism is associated with increased non-small cell lung cancer (NSCLC) risk. PMID: 23167403
- PDCD6 is a p53-responsive gene that induces apoptosis in response to DNA damage. PMID: 22712728
- PDCD6 is involved in ovarian cancer progression. PMID: 22369209
- PDCD6 activates the p53-p21 pathway, promoting cell cycle arrest and apoptosis. PMID: 22142513
- PDCD6 may play a role in advanced gastric cancer. PMID: 22161137
- PDCD6 modulates cellular angiogenesis. PMID: 21893193
- ALG-2 is stabilized by dimerization via its fifth EF-hand region. PMID: 11883899
- Annexin XI masks the calcium-dependently exposed hydrophobic surface of ALG-2. PMID: 11883939
- The penta-EF-hand domain of ALG-2 interacts with annexin VII and annexin XI in a calcium-dependent manner. PMID: 12445460
- ALG-2 influences both cell proliferation and cell death. PMID: 12445461
- ALG-2 is overexpressed in liver and lung neoplasms, predominantly in lung epithelial cells. PMID: 12819013
- ALG-2 downregulation in uveal melanoma cells may enhance survival by interfering with calcium-mediated apoptosis. PMID: 15366927
- Raf-1 may mediate its anti-apoptotic function by inhibiting ASK1-dependent ALG-2 phosphorylation. PMID: 15925322
- ALG-2 localizes to ER exit sites via calcium-dependent interaction with Sec31A, stabilizing Sec31A localization. PMID: 16957052
- ALG-2 and RBM22 co-localize in the nucleus. PMID: 17045351
- Sec31A is a novel ALG-2 target involved in ER-Golgi transport. PMID: 17196169
- Identification of Alix-type and Non-Alix-type ALG-2-binding sites in human phospholipid scramblase 3. PMID: 18256029
- Lower PDCD6 mRNA expression correlates with poor gastric cancer survival. PMID: 18957060
- Crystal structure analysis of N-terminally truncated human ALG-2. PMID: 18997320
- ALG-2 modulates MCOLN1 function in the late endosomal-lysosomal pathway. PMID: 19864416
- ALG-2 binds to the Fas death domain and dissociates during Fas-mediated apoptosis. PMID: 11606059
