pde-4 Antibody
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Product Specs
Buffer
**Preservative:** 0.03% Proclin 300
**Constituents:** 50% Glycerol, 0.01M PBS, pH 7.4
**Constituents:** 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Lead Time
Made-to-order (14-16 weeks)
Synonyms
pde-4 antibody; R153.1 antibody; Probable 3',5'-cyclic phosphodiesterase pde-4 antibody; EC 3.1.4.17 antibody
Target Names
pde-4
Uniprot No.
Target Background
Function
PDE-4 is an enzyme that hydrolyzes cyclic adenosine monophosphate (cAMP), a crucial second messenger involved in a wide range of physiological processes. It plays a role in antagonizing dorsal D (DD) motor neuron respecification by reducing cAMP levels.
Gene References Into Functions
- Studies have shown that loss of function and neural overexpression of PDE-4 have significant and opposing effects on locomotion rate. However, drug-response assays indicate that loss of PDE-4 function does not influence steady-state acetylcholine release or reception. PMID: 16624912
Database Links
STRING: 6239.R153.1d
UniGene: Cel.17824
Protein Families
Cyclic nucleotide phosphodiesterase family
Tissue Specificity
Expressed in dorsal D (DD) motor neurons and several other neurons at the L1 stage. Expression in DD neurons decreases gradually beginning in the late L1 stage. Highly expressed in adult ventral D (VD) motor neurons, but diminished in adult DD motor neuro
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