pdfr-1 Antibody
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Product Specs
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Lead Time
Made-to-order (14-16 weeks)
Synonyms
pdfr-1; seb-1; C13B9.4; Calcitonin receptor-like protein 1; Pigment dispersing factor neuropeptide receptor homolog 1
Target Names
pdfr-1
Uniprot No.
Target Background
Function
The pdfr-1 antibody targets the G-protein coupled receptor for PDF neuropeptides. This receptor is activated by peptides PDF-1 and PDF-2, though it exhibits a lower activation rate with isoform c. Isoforms a and b are believed to function through the G-alpha(s) type of G proteins to elevate cAMP levels, while isoform c inhibits cAMP levels through the G-alpha(i/o) type of G proteins. The pdfr-1 receptor is involved in locomotion, specifically playing a role in mate searching behavior independent of nutritional status. It may also contribute to touch sensitivity.
Gene References Into Functions
- The PDFR-1 pathway operates within non-sex-specific neurons to generate a male-specific, goal-oriented exploratory behavior. PMID: 23143519
- The pdfr-1 mutant exhibits a locomotor behavior phenotype that mirrors the defects observed in the pdf-1 mutant. PMID: 22579613
Database Links
STRING: 6239.C13B9.4a.1
UniGene: Cel.22708
Protein Families
G-protein coupled receptor 2 family
Subcellular Location
Cell membrane; Multi-pass membrane protein.
Tissue Specificity
Expression was observed in the mechanosensory neuron pairs PLM, ALM, FLP, OLQD, and OLQV, the chemosensory neurons PHA, PHB, RMEV, the ring motor neurons RMED, and the pharyngeal interneuron pair I1. In both hermaphrodites and males at the L4 stage expres
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