PDIL5-3 Antibody

PDIA5 (PDIL5-1) in Cancer and Immune Regulation

• PDIA5 is a member of the protein disulfide isomerase family involved in unfolded protein response pathways and tumor immunity .

• Overexpression correlates with poor clinical outcomes in cancers and modulates immune cell infiltration .

• Silencing PDIA5 reduces tumor cell proliferation and macrophage migration .

PDIL5-1 in Plant Virus Resistance

• PDIL5-1 serves as a susceptibility factor for Bymoviruses in barley. Loss-of-function mutations confer resistance .

• CRISPR/Cas9 editing of PDIL5-1 alleles in barley produces transgene-free, virus-resistant mutants without growth penalties .

Critical Observations:

• Nomenclature Discrepancy: The term "PDIL5-3" does not appear in any provided source. PDIL5-1 and PDIA5 are distinct entities with no evidence of a "PDIL5-3" isoform in these studies.

• Potential Mislabeling: The numbering conventions (e.g., PDIL5-1 vs. PDIL5-3) suggest possible confusion between homologs or paralogs across species. For example:

  • PDIL5-1: Barley (Hordeum vulgare) .

  • PDIA5: Human (Homo sapiens) .

Recommendations:

1. Verify the accuracy of the compound name "PDIL5-3 Antibody."

2. Explore alternative nomenclature (e.g., PDIA5, PDIL5-1) or species-specific isoforms.

3. Consult additional databases (e.g., UniProt, PubMed) for "PDIL5-3" beyond the provided sources.