PDV2 Antibody
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Product Specs
Buffer
Preservative: 0.03% ProClin 300; Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Lead Time
14-16 weeks (Made-to-order)
Synonyms
PDV2 antibody; At2g16070 antibody; F7H1.9 antibody; Plastid division protein PDV2 antibody; Protein PLASTID DIVISION2 antibody
Target Names
PDV2
Uniprot No.
Target Background
Function
PDV2 is a component of the plastid division machinery. Its function is crucial for the recruitment of ARC5 to the midplastid constriction site in the cytoplasm. PDV2 acts as a relay, communicating plastid division site position between the stroma and outer surface through interactions with cytoplasmic ARC5 and the inner membrane protein ARC6, which in turn recruits the stromal FtsZ ring.
Gene References Into Functions
PDV2's role in chloroplast division is supported by several key findings:
1. The PDV2 carboxy terminus inserts into a pocket within ARC6, inducing dimerization of the intermembrane space regions of two ARC6 molecules. A PDV2 mutant with impaired ARC6 dimerization exhibited abnormal ARC6 ring morphology and compromised chloroplast division. [PMID: 28248291]
2. PDV2 is a significant positive regulator of chloroplast division in Arabidopsis, demonstrating a clear dose-dependent effect. [PMID: 27988788]
3. PDV1 and PDV2 inhibit DRP5B-mediated GTP hydrolysis in a ratio-dependent manner. [PMID: 23595201]
4. ARC6 coordinates the inner and outer chloroplast membrane division machineries through interaction with PDV2 in the intermembrane space. [PMID: 18812496]
Database Links
Subcellular Location
Plastid, chloroplast outer membrane; Single-pass membrane protein. Note=Plastid equatorial positioning in a discontinuous ring mediated by ARC6.
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