PECAM1 (Ab-713) Antibody

Rabbit IgG in phosphate-buffered saline (PBS) without Mg²⁺ and Ca²⁺, pH 7.4, 150 mM NaCl, 0.02% sodium azide, and 50% glycerol.

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PECAM1

P16284

PECAM1 (Platelet Endothelial Cell Adhesion Molecule-1, also known as CD31) is a cell adhesion molecule crucial for leukocyte transendothelial migration (TEM) under most inflammatory conditions. Tyrosine 690 (Tyr-690) plays a critical role in TEM, facilitating efficient PECAM1 trafficking to and from the lateral border recycling compartment (LBRC). Tyr-690 is also essential for LBRC membrane targeting around migrating leukocytes. Trans-homophilic interactions contribute to endothelial cell-cell adhesion via cell junctions. Heterophilic interactions with CD177 facilitate neutrophil transendothelial migration. Homophilic PECAM1 ligation prevents macrophage-mediated phagocytosis of viable neighboring leukocytes by transmitting a detachment signal. Conversely, it promotes macrophage-mediated phagocytosis of apoptotic leukocytes by tethering them to phagocytic cells; this detachment signal appears disabled in apoptotic leukocytes. PECAM1 modulates bradykinin receptor BDKRB2 activation and regulates bradykinin- and hyperosmotic shock-induced ERK1/2 activation in endothelial cells. It is implicated in atherosclerosis susceptibility but does not offer protection against apoptosis.

• High CD31 expression is associated with Central Giant Cell Granuloma. PMID: 30139237
• TNF-α and IL-10 treatment affects ICAM-1 and CD31 expression in human coronary artery endothelial cells. PMID: 29949812
• High CD31 expression is associated with early-stage, but not late-stage, laryngeal squamous cell carcinoma. PMID: 29523110
• Adenocarcinomas exhibit significantly higher VEGF and αSMA staining scores than squamous cell carcinomas. In 42 cases with high CD31 scores, the five-year survival rate (87%) for lung cancer patients with mature tumor vessels was significantly better than that (69%) for patients with immature tumor vessels. PMID: 29970531
• Differences in CD31⁺ cytotoxic T lymphocyte trafficking during acute influenza infection may modulate tolerance and contribute to a dampened adaptive immune response in neonates. PMID: 28355204
• Cell adhesion assays on wildtype and mutant PECAM-1 characterized structural determinants in cell junctions and communication. PMID: 27958302
• In primary hip osteoarthritis (OA), angiogenesis may be induced by a combined mechanism involving hypoxia-related VEGF-dependent vasculogenesis and endothelial differentiation of activated pluripotent cells released from the hyperplastic synovial cell layer. Endothelial-mesenchymal transition is implicated in the fibrotic process. PMID: 27704157
• Preeclampsia shows upregulation of sVEGFR-1 with a concomitant decline in PECAM-1 and sVEGFR-2 levels, regardless of HIV status. PMID: 28609170
• Increased expression of PECAM-1, ICAM-3, and VCAM-1 in colonic biopsies from patients with inflammatory bowel disease (IBD) in clinical remission is associated with subsequent flares, suggesting these increases may be early events preceding flares. PMID: 27552332
• PECAM-1 gene polymorphisms are associated with Kawasaki disease, with and without coronary artery lesions, in Chinese children. PMID: 28512385
• Sirt1 expression is associated with CD31 expression in endothelial progenitor cells from patients with chronic obstructive pulmonary disease. PMID: 27784320
• Genetic heterogeneity of glycoproteins Ia and IIIa, platelet-endothelial cell adhesion molecule-1 (PECAM-1), and P-selectin genes cumulatively contributes to the risk of recurrent in-vitro fertilization/embryo transfer (IVF-ET) failures. The coexistence of these single nucleotide polymorphisms (SNPs) is associated with increased IVF-ET failure risk, with higher risk correlating to a greater number of polymorphic alleles or genotypes, particularly in younger women. PMID: 28388872
• Dimer conformation of soluble PECAM-1. PMID: 27270333
• RrgA binds both polymeric immunoglobulin receptor (pIgR) and PECAM-1, while the choline-binding protein PspC binds, to a lesser extent, only pIgR. PMID: 28515075
• This study demonstrates a significant role for CD31 during T cell development. PMID: 28159903
• Cells cultured in high glucose for 7 days showed a significant decrease in CD31 and VE-cadherin mRNA expression and a significant increase in α-SMA and collagen I mRNA expression. PMID: 28347704
• Patients with optic neuritis progressing to multiple sclerosis exhibited decreased serum PECAM-1 levels. PMID: 27806869
• Platelet endothelial cell adhesion molecule (PECAM-1) is expressed in endothelial cells, platelets, and leukocytes, regulating their interactions. PMID: 27079772
• No association was found between maternal or fetal ITGA2 C807T SNP, ITGB3 T1565C SNP, PECAM1 CTG - GTG, and SELP A/C polymorphisms and fetal growth restriction (FGR). PMID: 28358707
• A sialic acid-containing glycan emanating from Asn-25 reinforces dynamic endothelial cell-cell interactions by stabilizing the PECAM-1 homophilic binding interface. PMID: 27793989
• Decreased FoxP3 expression in CD31⁺ regulatory T (Tr) cells. PMID: 27997991
• PECAM-1 mediates platelet adhesion to endothelial cells under shear stress. Platelet binding to endothelial cells interferes with endothelial cell mechanotransduction through PECAM-1, affecting endothelial cell inflammatory responses to pathological shear flow. PMID: 28013181
• Immunohistochemical expression of CD31 and vascular endothelial growth factor (VEGF) were assessed in parallel. PMID: 27270504
• CD31 is expressed in mycosis fungoides (MF) skin biopsies, indicating a role for angiogenesis in MF progression. PMID: 27630298
• The Leu125Val polymorphism of PECAM-1 and soluble PECAM-1 levels are not associated with diabetic nephropathy in Caucasians with type 2 diabetes mellitus. PMID: 28116228
• Pro-angiogenic genes PECAM1, PTGS1, FGD5, and MCAM may play a vital role in the pathological dermal angiogenesis of psoriasis. PMID: 26748901
• PECAM-1 functions as an adhesive stress-response protein, maintaining endothelial cell junctional integrity and accelerating restoration of the vascular permeability barrier after inflammatory or thrombotic challenge. PMID: 27055047
• PECAM-1 enhances the inhibitory functions of TGF-β in T cells. PMID: 26956486
• PECAM-1 plays an important role in tight junction complex formation. PMID: 26607202
• Significant associations were detected for PECAM1*V/V + DDAH1*C (OR = 4.17, CI 1.56-11.15, Pperm = 0.005). PMID: 26662939
• Soluble CD38 (sCD38) in seminal plasma increases sperm capacitation via interactions between sCD38 and sperm CD31. PMID: 26407101
• CD31/PECAM1 expression is deregulated in human glioblastoma multiforme; correlations exist among CD31/PECAM1, HIF-1α, N-cadherin, and ADAM-10, markers of tumor aggressiveness. PMID: 26376118
• Radiation-induced stress causes transient granulocyte accumulation in the liver via down-regulation/absence of PECAM-1. PMID: 26177067
• CD31 expression correlates with prognosis in gastrointestinal stromal tumors. PMID: 26078569
• PECAM-1 125C/G polymorphism is associated with deep vein thrombosis. PMID: 25846278
• Endothelial cell heterogeneity changes during atherogenesis, affecting cell shape, adhesion molecule (ICAM-1, VCAM-1, and PECAM-1) expression, and lymphocyte and monocyte adhesion. PMID: 26841644
• PECAM1⁺ melanoma cells form vascular channels. PMID: 25335460
• Low shear stress induces inflammatory responses via the PECAM-1/PARP-1/HMGB1 pathway. PMID: 25793984
• Nck promotes oxidative stress-induced NF-κB activation by coupling PECAM-1 tyrosine phosphorylation to p21-activated kinase activation. PMID: 25714462
• PECAM-1 mediates the profibrotic and prometastatic effects of ethanol in endothelial cells. PMID: 24734240
• Correlation exists between mast cell tryptase and CD31 expression in odontogenic tumors. PMID: 26247531
• Associations exist between various PECAM-1 polymorphisms in rheumatoid arthritis and systemic lupus erythematosus (SLE) patients; PECAM-1 polymorphisms in SLE may be protective against atherosclerotic complications. PMID: 25201689
• Preeclampsia does not significantly affect vascular growth or endothelial junction protein expression in human placentas. PMID: 25362142
• CD31⁻ cells have impaired angiogenic potential; circulating CD31⁺ cell numbers correlate with cardiovascular disease risk. PMID: 25267411
• A functional link exists between HO-1 gene expression and PECAM-1 in endothelial cells, potentially regulating inflammation. PMID: 24500083
• A positive correlation exists between polymorphic nuclear monocyte content and expression levels of LFA-1, ICAM-1, LFA-3, and PECAM-1. PMID: 25884075
• High CD31 expression is significantly associated with better survival; VEGFR3 showed no association with survival. Higher tumor grade and stage correlated with decreased survival time. PMID: 25667475
• Cell confluence and flow type are critical factors in inducing TF and PECAM-1 phosphorylation in endothelial cells exposed to disturbed pulsatile flow and chemical stimuli. PMID: 24342062
• The regulated adhesive properties of PECAM-1 suggest novel approaches for controlling endothelial cell migration and barrier function in vascular permeability disorders. PMID: 24936065
• For angiosarcoma cytological diagnosis, ERG and CD31 are more sensitive vascular markers than CD34. PMID: 25352641

HGNC: 8823

OMIM: 173445

KEGG: hsa:5175

UniGene: Hs.376675

Cell membrane; Single-pass type I membrane protein.; [Isoform Long]: Cell membrane; Single-pass type I membrane protein. Membrane raft. Cell junction.; [Isoform Delta15]: Cell junction. Note=Localizes to the lateral border recycling compartment (LBRC) and recycles from the LBRC to the junction in resting endothelial cells.

Expressed on platelets and leukocytes and is primarily concentrated at the borders between endothelial cells. Expressed in human umbilical vein endothelial cells (HUVECs) (at protein level). Expressed on neutrophils (at protein level). Isoform Long predom