lin-42 Antibody
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Product Specs
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Lead Time
Made-to-order (14-16 weeks)
Synonyms
lin-42 antibody; F47F6.1 antibody; Period protein homolog lin-42 antibody; Abnormal cell lineage protein 42 antibody
Target Names
lin-42
Uniprot No.
Target Background
Function
LIN-42 is a transcriptional repressor that interacts with the promoter regions of target genes. It plays a critical role in developmental timing, regulating the temporal expression of various miRNAs and mRNAs. LIN-42 controls temporal cell fate transitions during embryonic and early larval development by regulating the expression of specific miRNAs, including let-7, miR-48, lin-4, miR-35, and miR-58. It restricts the accumulation of LIN-29 in the hypodermis until the larval L4 stage, thereby controlling the terminal differentiation of seam cells. LIN-42 is involved in miRNA-mediated specification of asymmetric gene expression patterns in gustatory neurons. It may also regulate genes involved in diverse biological processes such as transport, small molecule metabolism, and growth. LIN-42 inhibits dauer formation by antagonizing DAF-12. It is specifically required for maintaining the timing of larval development and molting cycle rhythms.
Gene References Into Functions
- The method's validity was confirmed using a lin-42 mutant strain exhibiting delayed development compared to wild-type animals and a daf-2 mutant displaying an extended second larval stage. PMID: 26294666
- A key function of lin-42 in developmental timing is to dampen pri-miRNA levels, preventing their premature expression as mature miRNAs. PMID: 25319259
- lin-42 functions to negatively regulate the transcriptional output of multiple miRNAs and mRNAs, thereby coordinating the expression levels of genes that dictate temporal cell fate. PMID: 25032706
- The Period protein homolog LIN-42 negatively regulates microRNA biogenesis in C. elegans. PMID: 24699545
- Inactivation of the heterochronic gene lin-42a leads to arrhythmic molts and abnormal epidermal stem cell dynamics. Oscillatory expression in the epidermis peaks during the molts; forced expression leads to anachronistic larval molts and adult lethargy. PMID: 22137474
- The C. elegans developmental timing protein LIN-42 regulates diapause in response to environmental cues. PMID: 20843862
- LIN-42 exhibits a dynamic expression pattern, with its levels oscillating relative to the molts during postembryonic development. PMID: 16300753
Database Links
STRING: 6239.F47F6.1b
UniGene: Cel.18253
Subcellular Location
Nucleus. Cytoplasm.
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