PER41 Antibody
Description
Potential Nomenclature Clarification
The query may reference two distinct entities:
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PER1 Antibody (Period Circadian Regulator 1) involved in circadian rhythm regulation
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gp41 Antibody targeting the HIV-1 envelope glycoprotein
Both are monoclonal antibodies with distinct biological targets and applications .
Table 1: Comparative Antibody Profiles
PER1 Antibody (E-8)
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Circadian Regulation: Binds to the N-terminal region of PER1, disrupting its interaction with TIM proteins and altering circadian periodicity in murine models .
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Therapeutic Potential: Used in studies linking circadian disruption to metabolic disorders (e.g., glucose intolerance observed in PER1-knockout mice).
gp41 Antibody (10E9)
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Viral Neutralization: Targets the membrane-proximal external region (MPER) of gp41, showing EC50 = 0.8 μg/mL in pseudovirus assays .
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Cross-Reactivity: SARS-CoV-2 spike antibodies demonstrate non-neutralizing cross-reactivity with gp41 epitopes (MFI >1,500 vs. HIV-1 pseudovirions) .
Figure 1: Antibody Efficacy Metrics
Product Specs
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Target Background
- Removal of H2O2
- Oxidation of toxic reductants
- Biosynthesis and degradation of lignin
- Suberization
- Auxin catabolism
- Response to environmental stresses such as wounding, pathogen attack, and oxidative stress
KEGG: ath:AT4G17690
STRING: 3702.AT4G17690.1
