PFKFB2 Antibody

1. The UCA1/miR-182/PFKFB2 axis influences chemokine CXCL14 secretion, glycolysis, and invasion of glioma cells within glioblastoma-associated stromal cells. PMID: 29655792
2. The crystal structure of human and cattle heart PFKFB2 has been elucidated, revealing the inhibitory effect of citrate on substrate binding. PMID: 27802586
3. Variations in PFKFB2 have been associated with reduced expression in adipose and kidney tissues, potentially increasing the risk of adiposity and diabetic nephropathy. PMID: 25662186
4. High levels of PFKFB2 protein are associated with hepatocellular carcinoma. PMID: 24568531
5. The bifunctionality of PFK-2/FBPase-2 contributes to metabolic zonation within the liver, ensuring coordinated switching in response to insulin and glucagon. PMID: 24634222
6. Amino acids stimulate Fru-2,6-P2 synthesis through Akt-dependent phosphorylation and activation of PFKFB2, highlighting the intricate link between signaling and metabolism. PMID: 23457334
7. Persistent increases in 6-phosphofructo-2-kinase, resulting from altered PFK-2/FBPase-2 isoform expression, may play a significant role in regulating muscle glycolysis. PMID: 22241065
8. Research suggests that PFKFB2 is not an essential upstream regulator of the anti-leukemic effects of glucocorticoids. PMID: 21092265
9. Androgen-induced de novo lipid synthesis requires transcriptional up-regulation of HK2 and PFKFB2, alongside PI3K/Akt signaling-mediated phosphorylation of PFKFB2, to provide the necessary substrate for lipogenesis from glucose in prostate cancer cells. PMID: 20958264
10. Human islets express the PFKFB2 and PFKFB3 isoforms. PFK-2/FBPase-2 protein, rather than its product fructose 2,6-P(2), is the primary determinant of glucose-induced insulin secretion by regulating glucokinase activity. PMID: 18039179

Show More

Hide All

HGNC: 8873

OMIM: 171835

KEGG: hsa:5208

STRING: 9606.ENSP00000356047

UniGene: Hs.282702