PHB4 Antibody

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Description

Potential Confusions with PF4 Antibodies

The search results extensively discuss anti-PF4 antibodies (Platelet Factor 4), which are central to conditions like heparin-induced thrombocytopenia (HIT) and vaccine-induced immune thrombotic thrombocytopenia (VITT). These antibodies target PF4, a chemokine involved in coagulation and platelet activation. Key findings include:

AspectDetailsSource
PathophysiologyAnti-PF4 antibodies form complexes with heparin or polyanions, activating platelets and causing thrombosis. In COVID-19, similar antibodies correlate with disease severity and microthrombi.
Diagnostic TestingELISA and chemiluminescence assays detect anti-PF4 antibodies, though specificity varies. Platelet activation assays (e.g., serotonin release) confirm pathogenicity.
Vaccine AssociationAdenovirus-vectored COVID-19 vaccines (e.g., AstraZeneca, J&J) rarely induce anti-PF4 antibodies, leading to VITT. Most individuals show no seroconversion post-vaccination.
Research ModelsRecombinant anti-PF4 antibodies (e.g., CR23003, CR23005) derived from VITT patients replicate platelet activation patterns, aiding mechanistic studies.

Potential Confusions with Prohibitin (PHB) Proteins

Search result discusses prohibitin (PHB) proteins (PHB1, PHB2), which are mitochondrial inner membrane proteins. No antibodies against PHB4 are mentioned, and PHB4 itself is not a recognized entity in the literature. Key points:

AspectDetailsSource
Prohibitin FunctionPHB1 and PHB2 form complexes critical for mitochondrial membrane stability and stress responses. Their localization is enriched in crista membranes.
Antibody UseAnti-PHB1 and PHB2 antibodies (e.g., EP2803Y, EPR14523) are used in immunogold electron microscopy and Western blotting to study prohibitin distribution and interactions.

Product Specs

Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Lead Time
Made-to-order (14-16 weeks)
Synonyms
PHB4 antibody; At3g27280 antibody; K17E12.10 antibody; Prohibitin-4 antibody; mitochondrial antibody; Atphb4 antibody
Target Names
PHB4
Uniprot No.

Target Background

Function
Prohibitin is believed to function as a holdase/unfoldase, playing a critical role in stabilizing newly synthesized mitochondrial proteins.
Database Links

KEGG: ath:AT3G27280

STRING: 3702.AT3G27280.1

UniGene: At.26847

Protein Families
Prohibitin family
Subcellular Location
Mitochondrion inner membrane; Single-pass type II membrane protein.
Tissue Specificity
Mostly expressed in proliferative tissues, including vasculature, shoot and root apical tissues. Accumulates in dry seeds.

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