PHF13 Antibody
Shipped with Ice Packs 
In Stock 
Product Specs
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Lead Time
We typically dispatch products within 1-3 business days of receiving your order. Delivery times may vary based on shipping method and location. Please contact your local distributor for specific delivery timeframes.
Synonyms
PHF13PHD finger protein 13 antibody; Survival time-associated PHD finger protein in ovarian cancer 1 antibody; SPOC1 antibody
Target Names
PHF13
Uniprot No.
Target Background
Function
PHF13 is a protein that plays a crucial role in regulating chromatin structure. It is essential for proper chromosome condensation during the early stages of mitosis and for accurate chromosome separation during mitosis.
Gene References Into Functions
- Elevated SPOC1 expression has been linked to Cytomegalovirus infections. PMID: 29743358
- PHF13 exhibits opposing effects throughout the HIV-1 replication cycle. Following viral entry and nuclear import of the pre-integration complex (PIC), PHF13 can increase the number of integrated HIV-1 proviral genomes. However, after integration, PHF13 functions as an antiviral restriction factor, inhibiting viral gene expression. PMID: 29021215
- Research has demonstrated that PHF13 binds specifically to DNA and to two distinct histone H3 methylation marks (lysine 4-tri-methyl or lysine 4-di-methyl), acting as a transcriptional co-regulator. PMID: 27223324
- SPOC1-mediated restriction on adenovirus (Ad) growth is alleviated by its functional association with the Ad major core protein pVII, which enters with the viral genome. Subsequently, E1B-55K/E4orf6-dependent proteasomal degradation of SPOC1 occurs. PMID: 24278021
- SPOC1 regulates chromatin structure, and precise control of its expression levels and subcellular localization during mitosis is critical for proper chromosome condensation and cell division. PMID: 19638409
Database Links
Subcellular Location
Nucleus. Nucleus, nucleoplasm. Note=Predominantly bound to chromatin, but a minor proportion is also detected in the nucleoplasm.
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