PHO4 Antibody
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In Stock 
Product Specs
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Lead Time
Made-to-order (14-16 weeks)
Synonyms
PHO4 antibody; YFR034C antibody; Phosphate system positive regulatory protein PHO4 antibody
Target Names
PHO4
Uniprot No.
Target Background
Function
PHO4 is a transcriptional activator that plays a critical role in regulating the expression of repressible phosphatases under phosphate starvation conditions. It binds to the upstream activating sequence (UAS) of several phosphatase-encoding PHO genes. Under high-phosphate conditions, PHO4 is inhibited by the cyclin-CDK complex PHO80-PHO85.
Gene References Into Functions
Gene References and Functions
- Pho85 and Pho4 regulate CLN2 expression under alkaline conditions. PMID: 25582350
- Further analysis of the inducible PHO5 gene demonstrates that topoisomerases are essential for Pho4p transcription factor binding to the PHO5 promoter. This binding is crucial for promoter nucleosome removal during gene activation. PMID: 23284296
- Research suggests that RPL12 has an extra-ribosomal function in modulating the transcription of genes that require Pho4p activation. PMID: 21469193
- A pathway controlled by Pho80-Pho85 kinase and Pho4 transcription factor can generate three distinct transcriptional outputs. PMID: 14624238
- These findings establish a G1 checkpoint adaptation pathway where Pho85 mediates Pho4 downregulation and Sic1 degradation, ultimately releasing Cdc28 activity and promoting the onset of the S phase. PMID: 16964260
- Pho4 binding to the SNZ1/SNO1 promoter is associated with changes in chromatin structure. Rpd3 histone deacetylase is required for proper timing of SNZ1/SNO1 expression, while Asf1 histone chaperone is essential for their expression. PMID: 18408055
- Pho4 activates certain stress response genes, is required for G1 arrest induced by DNA damage, and remains present in the nucleus even under high-phosphate conditions to regulate gene transcription. PMID: 19108609
Database Links
KEGG: sce:YFR034C
STRING: 4932.YFR034C
Subcellular Location
Cytoplasm. Nucleus. Note=Predominantly cytoplasmic under high-phosphate conditions and localized to the nucleus upon phosphate starvation.
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