Phospho-ADD1 (Ser726) Antibody

1. Studies have shown that alpha-adducin single nucleotide polymorphisms (SNPs) are not associated with bone density in lead workers. PMID: 29028685
2. Research suggests that ADD1 methylation may contribute to the pathogenesis of essential hypertension (EH) with varying implications for both genders. PMID: 28686109
3. The Gly460Trp gene polymorphism in ADD1 has been found to be significantly and independently associated with the risk of essential hypertension in a Caucasian population from Madeira Island. PMID: 29049185
4. Overexpression of ZNF322A has been shown to transcriptionally dysregulate genes involved in cell growth and motility, potentially contributing to lung tumorigenesis and poor prognosis. PMID: 26279304
5. The ADD1 rs4963 polymorphism has been associated with an increased risk of hypertension. PMID: 28040068
6. Research indicates that the ADD1 G460W polymorphism could be a significant factor in the pathophysiology of tinnitus. PMID: 27340988
7. Studies have shown that the alpha-adducin G460T polymorphism is associated with essential hypertension. PMID: 27349000
8. Research suggests that the ADD1-rs4963 polymorphism is associated with an increased risk of colorectal cancer (CRC), implying a potential link between ADD1 and CRC risk. PMID: 25816007
9. The T allele of ADD1 has been linked to essential hypertension in Asian populations. PMID: 26042478
10. Research investigating the interaction between DNA methylation of the ADD1 promoter, ADD1 tagSNPs, and environmental factors on essential hypertension (EH) indicates that ADD1 SNP rs4961 plays a protective role in the development of EH. Additionally, interactions between alcohol consumption and DNA methylation of the ADD1 gene promoter significantly influence EH susceptibility. PMID: 25567773
11. Significant differences in ACE I/D (P<0.05) and AGT M235T (P<0.05) polymorphisms were observed between the control group and pediatric hypertensive group, but no differences were found in ADD Gly460Trp (P>0.05) polymorphism. PMID: 25262176
12. A significant association was found between the ADD1 gene G614T polymorphism and essential hypertension in Chinese patients. Further studies are needed to validate these findings in larger cohorts. PMID: 24718403
13. When alpha-adducin forms complexes with sodium potassium ATPase in astrocytes, it triggers non-cell autonomous neurodegeneration. PMID: 25344630
14. Data suggest that adducin promotes adhesion by regulating desmosomes and is part of a protective pathway in pemphigus. PMID: 24711455
15. Phosphorylation of ADD1 at Ser12 and Ser355 by cyclin-dependent kinase 1 enables ADD1 to bind to myosin-X (Myo10). PMID: 24379415
16. Functional polymorphism in the phosphorylation site of ADD1 (rs4963) may influence the susceptibility of non-cardia gastric cancer. PMID: 23985264
17. In female controls, the concentration of aspartate aminotransferase (AST) was inversely correlated with ADD1 CpG2-5 methylation levels. These observations may provide insights into the pathogenesis of essential hypertension. PMID: 23691048
18. This meta-analysis is the first to assess the influence of ACE and ADD1 polymorphisms on blood pressure responses to hydrochlorothiazide, aiming to resolve inconsistencies found in previous studies. PMID: 23863317
19. The rs4963 polymorphism within the ADD1 gene has been linked to essential hypertension in the Chinese population. PMID: 23509723
20. The role of ADD1 gene polymorphism in hypertension has been investigated. PMID: 22810272
21. There was no association found between ACE and ADD1 gene polymorphism in ischemic stroke patients. PMID: 23540412
22. Genotype and allele frequencies of ACE and ADD1 polymorphisms were compared between patients and controls, as well as between ischemic stroke and intracerebral hemorrhage (ICH). PMID: 21194526
23. A hypertension-linked mutation in alpha-adducin has been shown to increase CFTR (cystic fibrosis transmembrane conductance regulator) surface expression and activity in HEK and cultured rat distal convoluted tubule cells. PMID: 23284854
24. Variant genotype combinations of ACE and alpha-adducin have been linked to increased vulnerability to recurrent intracerebral hemorrhage in hypertensive patients. PMID: 22198647
25. Genetic variants of the ADD1 and GNB3 genes may play a role in blood pressure response to the cold pressor test. PMID: 22476228
26. The organization of a spectrin-like cytoskeleton is associated with keratinocyte differentiation. Cytoskeleton disruption can be mediated by PKCdelta(Thr505) phosphorylation associated with phosphorylated adducin or by a reduction in endogenous adducin. PMID: 22163289
27. The alpha-adducin Gly460Trp gene polymorphism may modulate renal function decline in the Chinese population. PMID: 22677360
28. Findings suggest a role for alpha-adducin in memory across species, from nematodes to humans. PMID: 22307086
29. Data indicate that the alpha-adducin G460W gene polymorphism is linked to essential hypertension (EH) susceptibility. PMID: 22272309
30. Further studies involving siRNA-mediated knockdowns of spectrin, adducin, or p4.1 have revealed that these proteins are necessary for efficient docking of enterohaemorrhagic Escherichia coli to host cells. PMID: 22197999
31. Research has investigated the mechanism by which alpha-adducin shuttles between the cytoplasm and nucleus, suggesting a potential role for alpha-adducin in mitosis. PMID: 21736685
32. In the studied Russian population, the G460W polymorphism of the ADD1 gene can be considered a predisposition gene to hypertension. However, its pathological effect is only manifested under the influence of environmental factors. PMID: 22117679
33. No association was found between the alpha-adducin G460T and GNB3 C825T polymorphisms and hypertension in Chinese populations. However, marginal significance was observed for C825T, as a putative salt-sensitive switch, in southern Chinese populations. PMID: 21364877
34. This meta-analysis suggests that the Gly460Trp polymorphism may increase the risk of hypertension in Chinese populations, particularly in Han Chinese. PMID: 21228790
35. ADD1 variant genotypes were not associated with an increased risk of primary spontaneous intracerebral hemorrhage (PSICH) but, in association with the ACE DD genotype, resulted in significantly higher risk of PSICH. ACE and ADD1 variant genotypes were associated with nonlobar hematoma. PMID: 21339657
36. These findings indicate novel roles for adducins in the stabilization of epithelial junctions and regulation of junctional remodeling. PMID: 20810786
37. The alpha-adducin Gly460Trp polymorphism has been associated with hypertension. PMID: 20927398
38. Genetic variation in alpha-adducin that alters renal function and/or vasoreactivity are logical candidates to explain some of the individual variability in the blood pressure response to exercise. PMID: 20929695
39. Although the effect of both genetic variants on carotid intima-media thickness (CIMT) was small, this study showed a statistically significant effect of AGTR1 and ADD1 in women. PMID: 19620885
40. The alpha-adducin gene G460W polymorphism was not associated with hypertension in either a case-control study of essential hypertension in Shanghai residents or in a meta-analysis of all reports in English. PMID: 19960031
41. ALPHA AND BETA ADDUCIN POLYMORPHISMS AFFECT DECLINE OF RENAL FUNCTION IN HUMAN IGA NEPHROPATHY. PMID: 19838659
42. The alpha-adducin Gly460Trp polymorphism has been associated with salt-sensitivity. PMID: 20145305
43. The alpha-adducin G614T polymorphism is associated with the antihypertensive effect of hydrochlorothiazide. PMID: 16266470
44. Environmental, demographic, and genetic factors, and their interactions, contribute to the systolic blood pressure (SBP) response to antihypertensive drugs, explaining 23% of the total variance. Ethnicity, low sodium intake, and ADD1 614G-->T polymorphism were the only drug-related predictors. PMID: 19779464
45. The role of the alpha-adducin genotype on renal disease progression has been studied. PMID: 11918733
46. The interaction between diuretic therapy and the adducin variant on the incidence of myocardial infarction and stroke has been investigated. PMID: 11926892
47. The ADD1 460W allele has been associated with cardiovascular disease in hypertensive individuals. PMID: 12052841
48. Blood pressure in patients with primary aldosteronism is influenced by alpha-adducin gene polymorphisms. PMID: 12107246
49. Carotid and femoral intima-media thickness were assessed in subjects genotyped for the presence of the ACE D, aldosterone synthase -344T, and alpha-adducin 460Trp alleles. PMID: 12172317
50. Patients homozygous for the allele of that polymorphism had a left ventricular mass index significantly higher compared with heterozygotes or homozygotes. These subjects also have significantly lower plasma renin activity. PMID: 12195118

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HGNC: 243

OMIM: 102680

KEGG: hsa:118

STRING: 9606.ENSP00000264758

UniGene: Hs.183706