Phospho-ALOX5 (S272) Antibody

1. Our research indicates that ALOX5 plays a moderate anti-tumor role and functions as a drug sensitizer, demonstrating therapeutic potential in MLL-rearranged AML. PMID: 28500307
2. A study revealed that higher COX-2 and ALOX5 expression in colorectal cancer (CRC) tissues was correlated with poorer prognosis in patients with CRC. Furthermore, MiR-216a-3p was shown to directly bind to the 3'-UTR of ALOX5 and inversely regulates its protein levels, modulating CRC cell proliferation. PMID: 28786533
3. Findings suggest a potential protective role of ALOX5AP and 5-arachidonate lipoxygenase gene in diabetes type 2 pathogenesis. PMID: 29392977
4. Our data demonstrate that 5-LO, essential for leukotriene production and subsequent T cell recruitment, is downregulated in TAMs through Mer tyrosine kinase-dependent recognition of apoptotic cancer cells. PMID: 29229677
5. The study investigates the influence of TGFbeta/SMADs on MLL- and MLL-AF4-mediated 5-LO promoter activation. PMID: 28803964
6. Knockdown of arachidonate 5-lipoxygenase (Alox5) gene was found to induce decreased levels of bcl/abl mRNA and BCR/ABL fusion protein in K562/ADM cells, leading to an increased apoptosis rate. PMID: 29169426
7. Data suggest that the co-carcinogens benzidine and hydrogen peroxide induce expression of ALOX5 mRNA and protein in tracheobronchial epithelial cells. These co-carcinogens decrease cell proliferation but enhance apoptosis, effects inhibited by knockdown of ALOX5 using RNA interference. Benzidine appears to undergo metabolic activation to benzidine diimine by ALOX5. PMID: 25001243
8. This study identified an epistatic interaction among ALOX5, ALOX5AP, and MPO genes playing a significant role in vulnerability to ischemic stroke. PMID: 29041000
9. The anticancer effects by 13'-COOHs seem to be partially independent of COX-2/5-LOX inhibition. Using liquid chromatography tandem mass spectrometry, researchers found that 13'-COOHs increased intracellular dihydrosphingosine and dihydroceramides after short-time incubation in HCT-116 cells, and enhanced ceramides while decreasing sphingomyelins during prolonged treatment. PMID: 27016075
10. ROS production induced by the 5-LO pathway mediates the anti-cancer effects of docosahexaenoyl ethanolamide and N-arachidonoyl-L-alanine on head and neck squamous cell carcinoma cells. PMID: 27411387
11. Specific inhibitors of COX-2 and 5-LOX decreased the formation of HKD2 and HKE2. Platelets did not form HKs from exogenous 5S-hydroxyeicosatetraenoic acid, implying that COX-1 is not involved. PMID: 28096231
12. The observation that the coexpression of FLAP with a subset of the 5-LOX mutants restores 5-LOX-wild-type (wt)-like levels of products formed in intact cells suggests a physical protein-protein interaction, beyond colocalization, of 5-LOX and FLAP. PMID: 26842853
13. Polymorphisms in the 5-Lipoxygenase are associated with Incident Myocardial Infarction. PMID: 27893808
14. Our findings identify Alox5 as a key genetic effector of JAK2V617F in driving polycythemia vera. PMID: 27784744
15. Adipose tissue eicosapentaenoic acid and arachidonic acid, and the ALOX-5 tandem repeat polymorphism, did not significantly interact to affect the risk of myocardial infarction. PMID: 28566527
16. Coexpression of the isoforms inhibited or stimulated 5-LO-WT expression in transiently and stably transfected HEK293T cells, suggesting that the isoforms have other functions beyond canonical leukotriene biosynthesis. PMID: 28257804
17. A novel putative protein isoform of human 5-LO lacking exon 4, termed 5-LODelta4, was identified. PMID: 27855198
18. Oxidative stress decreased the levels of PNPLA2 transcripts without affecting ALOX5 expression. Exogenous additions of P1 peptide or overexpression of the PNPLA2 gene decreased both LTB4 levels and death of RPE cells undergoing oxidative stress. PMID: 27635633
19. Dimethyl ester of bilirubin exhibits anti-inflammatory activity by inhibiting secretory phospholipase A2, lipoxygenase, and cyclooxygenase. PMID: 27060751
20. Copy number variation in ALOX5 is associated with NSAIDs-induced urticaria and/or angioedema. PMID: 26959713
21. This study identified a SNP (rs10507391) in the ALOX5 gene as a novel genetic risk factor for Alzheimer's disease and body mass index. PMID: 26944113
22. ALOX5 gene variants do not appear to be related to clinical CHD events or subclinical atherosclerosis, regardless of bioavailable enzyme substrate levels in a multiethnic cohort. PMID: 27025886
23. Our data suggest that inhibiting both COX-2/5-LOX may be an effective therapeutic approach for colon cancer management, particularly for patients with high expression of COX-2/5-LOX. PMID: 26707712
24. We identified differences in the frequency distribution in the Tibetan population located in the ALOX5, VKORC1, and PTGS2 genes. PMID: 26505400
25. AF4 and AF4-MLL mediate transcriptional elongation of 5-lipoxygenase mRNA by 1, 25-dihydroxyvitamin D3. PMID: 26329759
26. The Alox-5 gene might play a role in the differentiation of multiple drug resistant and non-resistant erythroleukemic cell lines. PMID: 26852002
27. These results suggest that COX-2 and 5-LO play roles in tumorigenesis and the progression of primary glioblastoma. The co-expression pattern of COX-2/5-LO may be used as an independent prognostic factor in this disease. PMID: 26334317
28. Increased PUFA content and 5-lipoxygenase pathway expression are associated with subcutaneous adipose tissue inflammation in obese women with type 2 diabetes. PMID: 26378572
29. The study shows that 5-lipoxygenase (5-LO) in B cells is phosphorylated on Ser523. This demonstrates for the first time a chemical difference between 5-LO in myeloid cells and B cells. PMID: 26210919
30. A novel splice variant of 5-LO consisting of 139 amino acids due to premature stop was identified. It was found to be expressed in HepG2 cells only, raising the possibility of a putative role in liver cancer development. PMID: 25218842
31. GSAP cleavage via caspase-3 is regulated and depends upon the availability of 5-Lipoxygenase in Alzheimer's disease. PMID: 26076991
32. The study investigated potential mechanisms by which 5-LO13 interferes with 5-LO product biosynthesis in transfected HEK293 cells. PMID: 26173130
33. Two of the most potent/selective inhibitors (HIR-303 and HIR-309) were reductive inhibitors and were potent against 5-LOX in human whole blood. This indicates that isoflavans can be potent and selective inhibitors against human leukocyte 5-LOX. PMID: 25359714
34. The study explores the substrate access portal of 5-Lipoxygenase. PMID: 26427761
35. Lipoxygenase pathways are involved in TNF-alpha-induced production of cytokines and chemokines. PMID: 25229347
36. No association was found between ALOX5 SNPs and atherosclerotic plaque phenotypes. PMID: 25721704
37. The 5-LOX interface involving the four cysteines 159, 300, 416, and 418 is crucial for translocation to the nuclear membrane and colocalization with FLAP. PMID: 26327594
38. Genotoxic stress induces ALOX5 mRNA and protein expression in a p53-dependent manner. PMID: 26070487
39. Results indicate that 5-LOX expression levels were increased in pancreatic cancer tissues, potentially related to lymph node metastasis and TNM stage. PMID: 25483364
40. Low leukotriene B4 receptor 1 leads to ALOX5 downregulation at the diagnosis of chronic myeloid leukemia. PMID: 25193960
41. 5-LOX inhibition reduced apoptotic death, restored the initial IL-2/INF-gamma ratio, and importantly, reverted micro-calpain activation induced by simulated microgravity. PMID: 25309925
42. ALOX5 contributes to the inflammatory microenvironment of precancerous pancreatic lesions. PMID: 25454978
43. Increased metabolites of 5-lipoxygenase from hypoxic ovarian cancer cells promote tumor-associated macrophage infiltration. PMID: 24662827
44. These findings indicate that the oncogenic function of c-Myc in prostate cancer cells is regulated by 5-Lox activity, revealing a novel mechanism of 5-Lox action. PMID: 25540201
45. Human cytomegalovirus (HCMV) induced up-regulation of 5-lipoxygenase in both ex vivo HCMV-infected placental explants and human umbilical vein endothelial cells (HUVEC). PMID: 24746852
46. Jurkat T cells overexpressing 5-LO failed to activate PPARgamma in macrophages, while their 5-LO overexpressing apoptotic counterparts did. PMID: 24036216
47. Polymorphisms within FLT3, EGFR, NEIL3, and ALOX5 may contribute to the occurrence of GBM. PMID: 24005813
48. 5-LO disruption improves wound healing and alters fibroblast function through an antioxidant mechanism based on HO-1 induction. PMID: 24226420
49. Changes in LTB4 concentration in serum and the mRNA expression level of 5-LO in decidua may play a significant role in the success and maintenance of a healthy pregnancy. PMID: 23572152
50. The 5-LOX/LTC4/CysLT1 signaling pathway regulates EGF-induced cell migration by increasing Tiam1 expression. PMID: 24350867

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HGNC: 435

OMIM: 152390

KEGG: hsa:240

STRING: 9606.ENSP00000363512

UniGene: Hs.89499