Phospho-CD40 (T254) Antibody

• CD40 is a critical molecule in the upregulation of HIF-1alpha and PTEN, contributing to the severity of microangiopathy. PMID: 29549140
• The CD40 rs1883832 T allele is associated with increased susceptibility to sepsis. It may be involved in sepsis by regulating CD40 expression and plasma sCD40L levels. PMID: 29780830
• The 3'-UTR CD40LG (CA)n microsatellite is not a genetic marker for rheumatoid arthritis in the western Mexican population. However, findings suggest a role in CD40LG mRNA expression. PMID: 28963582
• LOAd703 is a designed adenovirus incorporating trimerized CD40L and 4-1BBL, which activates the CD40 and 4-1BB pathways, respectively. PMID: 28536305
• Inducible activation of MyD88 and CD40 in CAR T cells with a small-molecule drug enhances their effector function, resulting in potent antitumor activity in preclinical solid tumors. This also enables remote control of the cells post-infusion. PMID: 28801306
• The rs3765459 variant in the CD40 gene is linked to susceptibility to neuromyelitis optica spectrum disorders. PMID: 27578014
• An association between different CD40 SNPs and the susceptibility to Graves disease and Hashimoto's Thyroiditis has been identified in Chinese patients. This suggests that multiple susceptibility loci within CD40 may contribute to the development of autoimmune thyroid diseases (AITD). PMID: 28742400
• CD40 gene rs4810485 and rs1883832 mutations were investigated in patients with Recurrent aphthous stomatitis. PMID: 27875792
• Data demonstrate that miR-145-5p may function as a cardiac-protective molecule in myocardial ischemic injury by mitigating inflammation and apoptosis via negative regulation of CD40. PMID: 28281187
• rs4810485 G>T and rs1883832 C >T SNPs in the CD40 gene may be associated with disease susceptibility and severity in knee osteoarthritis in the Chinese Han population. PMID: 28320398
• miR-145 is involved in the anti-proliferation and anti-inflammatory effects of aspirin on vascular smooth muscle cells by inhibiting the expression of CD40. PMID: 27412561
• Selective knockdown of TNFR5 ameliorates glucolipotoxic induction of STAT1 expression and NF-kappaB activity. PMID: 27512950
• CD40 signaling in adipose tissue macrophages regulates major histocompatibility complex class II and CD86 expression, controlling the expansion of CD4(+) T cells. PMID: 26658005
• CD40 activation leads to down-regulation of Thioredoxin (Trx)-1, permitting ASK1 activation and apoptosis. While soluble receptor agonist alone cannot induce death, combinatorial treatment with soluble CD40 agonist and pharmacological inhibition of Trx-1 mimics the signal triggered by mCD40L. PMID: 27869172
• Autologous CD4(+) T cells exposed to EVs from CD40/IL-4-stimulated CLL cells exhibit enhanced migration, immunological synapse signaling, and interactions with tumor cells. PMID: 27118451
• Cytokine expression upon simultaneous stimulation of TSHR and CD40 is greater than with TSH or CD40L alone. Increased CD40 expression by TSH is a potential mechanism for this process. PMID: 27631497
• Glatiramer acetate treatment significantly reduces CD40-mediated P65 phosphorylation in RRMS patients, suggesting that reducing CD40-mediated p-P65 induction may be a general mechanism by which some current therapies modulate Multiple Sclerosis disease. PMID: 27798157
• Circulating sCD40L levels are elevated in patients with cystic fibrosis and P. aeruginosa infection. PMID: 28030642
• Results support a strong association of rs4810485 in the CD40 gene and rs763361 in the CD226 gene polymorphism. The combined effect of these polymorphisms is associated with an increased risk of systemic lupus erythematosus. PMID: 27722794
• CD40 activity in thyrocytes is predominantly mediated via NF-kappaB. PMID: 27929668
• Polymorphisms in the TP63 and CD40 genes are associated with lung cancer in a Chinese Han population. PMID: 27063419
• Increased CD40 ligation and reduced B-cell receptor signaling lead to higher IL-10 production in B cells from tolerant kidney transplant recipients. PMID: 27472092
• Essential hypertension patients exhibit increased expression of platelet CD40. PMID: 27090943
• CD40 monocyte is a novel inflammatory monocyte subset that may serve as a biomarker for chronic kidney disease severity. PMID: 27992360
• rs1535045 in the CD40 gene is likely associated with Coronary Artery Disease (CAD) in the Chinese Han population. The rs4239702(C)-rs1535045(T) haplotype is linked to CAD, and patients with the rs4239702-TT genotype have higher blood lipid levels compared to others. PMID: 27200368
• CD40 SNPs rs1883832 and rs4810485 are not RA susceptibility markers in the western Mexican population. Further research is needed to understand their roles in CD40 mRNA expression. PMID: 27813548
• Functional expression of CD40 on tumor cells may play a significant role in tumor progression and lymph node metastasis in esophageal squamous cell carcinoma. PMID: 27630283
• CD40/CD40L interactions and TNF alpha are likely effective against cervical carcinomas by suppressing the transcriptional activity of the human papilloma virus-18 promoter. PMID: 27031714
• Antigen targeting to CD40 can elicit potent antigen-specific CD8(+) T cell responses in human CD40 transgenic mice. PMID: 27077111
• Findings suggest that the CD40 -1C/T SNP (rs1883832) is correlated with lung cancer susceptibility in the Chinese population, with the TT genotype potentially increasing the risk. PMID: 26823861
• The CD40/CD40L system plays a role in regulating bone mineral density. PMID: 26545336
• Significant differences exist in the gene and allele frequencies of the CD40 gene rs1883832 C/T polymorphism between patients with systemic lupus erythematosus and controls. sCD40 levels are elevated in SLE patients compared to controls. PMID: 26289938
• Preliminary evidence suggests that CD40 may promote tumor growth by facilitating immune evasion through MDSC recruitment and inhibition of T cell expansion. PMID: 26462153
• Results highlight new roles for CD40 and cysteine-238-mediated CD40 homodimers in cell biology. This identifies a potential new target for therapeutic strategies against CD40-associated chronic inflammatory diseases. PMID: 25977307
• Meta-analyses confirm that the CD40 rs4810485 G/T polymorphism is associated with susceptibility to rheumatoid arthritis and systemic lupus erythematosus in Europeans. PMID: 25908480
• Platelet CD40 plays a critical role in inflammation by stimulating leukocyte activation and recruitment, as well as endothelial cell activation, thereby promoting atherosclerosis. PMID: 26821950
• The CD40 gene may play a role in the development of systemic lupus erythematosus in the Chinese population. PMID: 26474561
• Studies suggest that the CD40 antigen/CD154 antigen pathway represents a promising potential therapeutic target for preventing transplantation rejection. PMID: 26268734
• A study shows a multiple sclerosis (MS) risk genotype-dependent reduction of CD40 cell-surface protein in B-lymphocytes and polarized dendritic cells. MS patients, regardless of genotype, express lower levels of CD40 cell-surface protein compared to controls in B lymphocytes. Both genotype-dependent and independent downregulation of cell-surface CD40 is a characteristic of MS. PMID: 26068105
• The ability of IL21 to modulate gene and miRNA expressions in CD40-activated Chronic Lymphocytic Leukemic cells was investigated. PMID: 26305332
• Direct CD40-CD40L interaction between breast tumor cells and activated T cells increases TGF-beta production and Th17 cell differentiation, which promotes the proliferation of breast cancer cells. PMID: 25992978
• Differences in CD40 expression levels due to different genotypes of the two SNPs (rs4810485 and rs1883832) may contribute to the development of skin lesions or genital ulcers in patients with Behcet disease. PMID: 25373542
• The CD40 rs1883832C>T SNP decreases CD40 gene expression. PMID: 25600834
• The presence of CD40 on the T cell membrane is crucial for the induction of recombinase activity in patients with autoimmune type 1 diabetes mellitus. PMID: 22803080
• CD40 expression is significantly correlated with TNM stage and the presence of distant metastasis in gastric carcinoma patients. PMID: 25665853
• CD40 signaling results in sustained ERK1/2 activation and up-regulation of Bcl-xL in BCR-primed HF1A3 germinal center B cells. PMID: 26054744
• Subjects with the chronic hepatitis B (CHB) risk genotype TT of rs1883832 have the lowest plasma concentration of CD40, followed by subjects with CT and CC genotypes in both healthy controls and CHB patients. PMID: 25802187
• On the surface of B lymphocytes, CD40 expression levels in individuals with the TT genotype are significantly lower than those with CC and CT genotypes in both the ASC group and healthy controls. PMID: 25547203
• A possible additive combined effect between CD40-1C>T and CTLA4+6230G>A polymorphisms in the development of Graves' disease. PMID: 25936345
• No association exists between CD40 polymorphisms and acute rejection in German liver transplant recipients. PMID: 25305459

HGNC: 11919

OMIM: 109535

KEGG: hsa:958

STRING: 9606.ENSP00000361359

UniGene: Hs.472860