Phospho-CLDN6 (Y219) Antibody

1. Antibodies recognizing native CLDN6 expressed on cell surfaces and mediating complement-dependent cytotoxicity were generated in vaccinated animals. This data suggests potential applications of CLDN6-displaying Virus-like particles in cancer immunotherapy. PMID: 29131519
2. Research indicates that Helicobacter pylori lipopolysaccharide induces TLR2 expression in gastric adenocarcinoma cells. Prolonged exposure to lipopolysaccharide leads to increased expression of TLR2 on the cell membrane, consequently enhancing the expression of claudin-4, -6, -7, and -9. PMID: 29031421
3. This study provides evidence that high expression of CLDN6 confers chemoresistance on breast cancer, mediated by GSTP1, whose activity is regulated by p53. PMID: 29116019
4. CLDN6 enhances chemoresistance to ADM by activating the AF-6/ERK signaling pathway and upregulating cancer stem cell characteristics in MDAMB231 cells. PMID: 29159771
5. Research demonstrates that the downregulation of CLDN6 is regulated through promoter methylation by DNMT1, which is dependent on the SMAD2 pathway. CLDN6 acts as a key regulator in the SMAD2/DNMT1/CLDN6 pathway to inhibit epithelial-mesenchymal transition (EMT), migration, and invasion of breast cancer cells. PMID: 28867761
6. In conclusion, the bioinformatics analysis provides valuable insights that will aid future investigations aimed at a deeper understanding of CLDN6 regulation and functions. PMID: 28656265
7. High expression of CLDN6 was observed in approximately 65% of myxofibrosarcomas, while benign soft tissue tumors did not exhibit high CLDN6 expression. CLDN6 expression in myxofibrosarcomas was significantly higher compared to other tumor specimens. Notably, high CLDN6 expression in myxofibrosarcomas correlated with higher FNCLCC grades and AJCC stages. PMID: 28476380
8. Results indicate that DNA methylation downregulates CLDN6 expression through MeCP2 binding to the CLDN6 promoter, deacetylating H3 and H4, and altering chromatin structure, thereby promoting migratory and invasive phenotypes in breast cancer cells. PMID: 27461117
9. Cldn6 expression was decreased in alveolar type II-like epithelial cells (A549) and primary small airway epithelial cells upon exposure to cigarette smoke extract. PMID: 27982694
10. Evidence suggests that claudin-6 induces MMP-2 activation through claudin-1 membrane expression. PMID: 27914788
11. Data shows that claudin-6 (CLDN6) R209Q and occludin (OCLN) P24A mutations do not affect HCV pseudoparticles (HCVpp) entry. PMID: 26561856
12. The expression of ASK1 is correlated with the level of claudin-6 in cervical carcinoma cells and tissues. PMID: 26191261
13. High levels of CLDN6 are associated with non-small-cell lung cancer. PMID: 24710653
14. The expression of claudin-6 was downregulated in gastric cancer tissue. PMID: 23919729
15. Only certain hepatitis C virus strains effectively utilize CLDN6 for infection. PMID: 23775920
16. This work provides proof of concept for the use of Claudin-6 to eliminate residual undifferentiated human pluripotent stem cells from culture. PMID: 23778593
17. While claudin-6 and claudin-9 can serve as entry factors in cell lines, hepatitis C virus infection into human hepatocytes is not dependent on claudin-6 and claudin-9. PMID: 23864633
18. ASK1 signaling may play a positive role in the inhibitory effect of claudin-6 in breast cancer. PMID: 22925655
19. Research indicates that claudin-6 protein is significantly downregulated in breast invasive ductal carcinomas. PMID: 22455563
20. CLDN6 is not a specific biomarker for atypical teratoid rhabdoid tumors as it is expressed in various other pediatric CNS and soft tissue tumors. PMID: 21989342
21. 17beta-E2 may regulate the expression of claudin-6 and inhibit the proliferation and migration of MCF-7 cells. PMID: 20388399
22. Increased expression of claudin-6, claudin-7, or claudin-9 is sufficient to enhance tumorigenic properties of a gastric adenocarcinoma cell line. PMID: 20874001
23. CLDN6 may be a useful positive marker to further identify atypical teratoid/rhabdoid tumors for diagnostic and treatment purposes. PMID: 19220299
24. Claudins 6, 7, and 9 expressions are closely related to gastric carcinogenesis. PMID: 19960275
25. The upregulation of claudin-6 expression in MCF-7 breast cancer cells suppresses their malignant phenotypes, correlated with the restoration of tight junction integrity. PMID: 20367941
26. Claudin-6 downregulates the malignant phenotype of breast carcinoma. PMID: 20215972
27. Claudin 6 was not found in epithelioid glioblastomas or rhabdoid glioblastomas. PMID: 20118769
28. CLDN6 and CLDN9, but not CLDN1, are expressed in peripheral blood mononuclear cells, an additional site of HCV replication. PMID: 17804490
29. Claudin-6 and claudin-9 expressed in CD81+ cells also enable the entry of HCV pseudoparticles derived from six of the major genotypes. PMID: 18234789
30. CLDN6, clustered with CLDN9 at human chromosome 16p13.3, is a four-transmembrane protein with WWCC motif, defined by W-X(17-22)-W-X(2)-C-X(8-10)-C. PMID: 12736707

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HGNC: 2048

OMIM: 615798

KEGG: hsa:9074

STRING: 9606.ENSP00000328674

UniGene: Hs.533779