Phospho-CSNK1A1 (Y321) Antibody

• Research indicates that CK1alpha destabilizes FOXO4 in RAS-mutant cells by phosphorylation at serines 265/268. PMID: 28945225
• Data suggest that casein kinase 1 alpha (CK1alpha) RNA levels may serve as a prognostic marker for colorectal cancer (CRC). PMID: 29409464
• Cellular casein kinase 1 alpha (CK1alpha) is crucial for the influenza A virus (IAV) hemagglutinin (HA)-induced degradation of both IFNGR1 and IFNAR1. PMID: 29343571
• Casein kinase 1 phosphorylates the SQSTM1 S349 residue when harmful proteins accumulate under heat shock factor 1 (HSF1) stress. PMID: 27846364
• Maintenance of progenitor cells requires the cooperative action of PRMT1 and CSNK1a1 to sustain proliferation gene expression and suppress premature differentiation driven by GRHL3. PMID: 28943242
• These data indicate that CK1alpha has a dominant and non-redundant function in melanoma cells. PMID: 27488834
• Disruption of CK1alpha function in myeloma cells resulted in decreased Mdm2, increased p53 and p21, and reduced expression of beta-catenin and AKT. PMID: 28099937
• CK1delta enhances erythropoietin (EPO) secretion from liver cancer cells under hypoxia by modifying HIF-2alpha and promoting its nuclear accumulation. PMID: 27686097
• CKIalpha-mediated NS5A S235 phosphorylation is critical for hepatitis C virus (HCV) replication. CaMKII gamma and delta may have negative roles in the HCV life cycle. PMID: 27875595
• Interactome analyses revealed that the Jade-1S mutant, unable to be phosphorylated by CK1alpha, has an increased binding affinity to proteins involved in chromatin remodeling, histone deacetylation, transcriptional repression, and ribosome biogenesis. PMID: 26919559
• This study focuses on the synchronized structural dynamics and conformational changes of two CK1 isoforms in the carcinogenic pathway. PMID: 26788877
• NIFK is required for lung cancer progression via the RUNX1-dependent CK1alpha repression, which activates TCF4/beta-catenin signaling in metastasis and the Ki-67-dependent regulation in cell proliferation. PMID: 26984280
• The study describes the identification of a novel, tumor-specific missense mutation in the active site of casein kinase 1 alpha (CSNK1A1) using activity-based proteomics. PMID: 27031502
• This study characterizes the frequency and potential clinical impact of CSNK1A1 mutations in myelodysplastic syndrome (MDS) and acute myeloid leukemia following MDS in a large cohort of patients. PMID: 25792355
• The dynamical and conformational properties of three CK1 isoforms are explored through molecular dynamics (MD) simulations. PMID: 25665722
• Phosphorylation of LRRK2 by casein kinase 1 alpha regulates trans-Golgi clustering via differential interaction with ARHGEF7. PMID: 25500533
• Casein kinase 1 alpha is a key negative regulator of oncogenic RAS-induced autophagy. Depletion or pharmacologic inhibition of CK1alpha enhanced autophagic flux in oncogenic RAS-driven human fibroblasts and multiple cancer cell lines. PMID: 25798617
• CSNK1alpha1 plays a role in mediating malignant plasma cell survival. PMID: 24962017
• Casein kinase 1 alpha specifically phosphorylates Jade-1 at an unprimed SLS phosphorylation site. PMID: 25100726
• Degradation of Tiam1 by casein kinase 1 and the SCFbetaTrCP ubiquitin ligase controls the duration of mTOR-S6K signaling. PMID: 25124033
• Data indicate that protein S phosphorylation by casein kinase 1 (CK1) and casein kinase 2 (CK2) increased activated protein C cofactor activity. PMID: 23580615
• The substrate interacting residues in CK1alpha have been identified using the structural model of kinase-substrate peptide. The PKR interacting NS5A 1b residues have also been predicted. PMID: 23148689
• DNA damage activates p53 in part by disrupting CK1a-MDMX interaction and reducing MDMX-p53 binding affinity. PMID: 23028042
• Casein kinase 1 alpha (CK1alpha) has been identified as a direct target of miR-155 control, which enhances beta-catenin signaling and cyclin D1 expression, promoting tumor cell growth. PMID: 22350414
• We showed that just four genes, G3BP2, SCARB2, CSNK1A1, and SPRR2B, can classify patients as having lymph node metastasis negative or positive, with 80.0% accuracy. PMID: 21985131
• mTOR cooperates with CK1alpha and betaTrCP to generate an auto-amplification loop to promote its own full activation. PMID: 22017877
• The authors characterized the role of CKIalpha in the circadian clock mechanism and found that CKIalpha-mediated phosphorylation stimulated degradation of the clock protein PER1, similar to the function of CKIdelta. PMID: 21179498
• Our results indicate that the nuclear form of CK1alpha in humans, CK1alphaLS, plays a critical role in vascular cell proliferation, cellular activation, and hydrogen peroxide-mediated mitogenic signal transduction. PMID: 20696773
• Casein kinase 1 functions as both a penultimate and ultimate kinase in regulating Cdc25A destruction. PMID: 20348946
• Biochemical and cellular characteristics of the four splice variants of protein kinase CK1alpha from zebrafish (Danio rerio) are presented. PMID: 12210746
• CK1alpha can promote cell survival by interfering with RXR agonist-induced apoptosis. PMID: 15131121
• CK1alpha-mediated phosphorylation modulates the mRNA binding ability of hnRNP-C. PMID: 15687492
• NFAT1, a transcription factor connected with breast cancer metastasis, is activated by Wnt-5a through a Ca2+ signaling pathway in human breast epithelial cells, which is simultaneously counteracted by a Wnt-5a-induced Yes/Cdc42 signaling pathway. PMID: 16880514
• The alpha isoform of casein kinase I has been identified as the cellular kinase important for the formation of hepatitis C virus (HCV) NS5A-p58; this study demonstrates the effects of this kinase on NS5A hyperphosphorylation and HCV replication. PMID: 16943283
• CK1alphaLS and hnRNP-C represent conserved components of a vertebrate-specific H(2)O(2)-responsive nuclear signaling pathway. PMID: 17626781
• Studies suggest that CK1alpha is another kinase that regulates RIP1 function in NF-kappaB activation. PMID: 18067272
• Following DNA damage, PML facilitates Thr18 phosphorylation by recruiting p53 and CK1 into PML nuclear bodies, thereby protecting p53 from inhibition by Mdm2, leading to p53 activation. PMID: 18246126
• Ser-155 and Ser-158 have important roles in the nucleocytoplasmic trafficking of OREBP/TonEBP, and CK1 plays a major role in regulating this process. PMID: 18411282
• Inhibition of CK1 activates RhoB and promotes RhoB-dependent actin fiber formation and EGF-R level. PMID: 18590726
• CK1 has a role as the Ser20 site kinase for p53 in DNA virus-infected cells. PMID: 18669630
• Phosphorylation of parkin by casein kinase I and cdk5 decreases parkin solubility, leading to its aggregation and inactivation. PMID: 19050041
• The 'activated B-cell-like' subtype of diffuse large B-cell lymphoma cells required CK1alpha for constitutive NF-kappaB activity, indicating that CK1alpha functions as a conditionally essential malignancy gene. PMID: 19118383
• Casein Kinase 1 phosphorylates serine 56 of yellow fever virus methyltransferase. PMID: 19185594
• Data show that Wnt-5a stimulation of breast epithelial cells leads to increased cell-cell adhesion, and that Wnt-5a/casein kinase Ialpha (CKIalpha)-specific phosphorylation of beta-catenin leads to increased complex formation of beta-catenin/E-cadherin. PMID: 19244247
• CK1alpha plays a central role in mediating MDM2 control of p53 and E2F-1 protein stability. PMID: 19759023
• Results suggest a role for mammalian and parasite casein kinase 1 alpha in regulating IFNAR1 stability and type I IFN signaling. PMID: 19805514

HGNC: 2451

OMIM: 600505

KEGG: hsa:1452

UniGene: Hs.529862