Phospho-CTTN (Tyr466) Antibody

1. Cortactin (CTTN) silencing in megakaryocyte (MK) phenocopies histone deacetylase 6 (HDAC6) inactivation and knockdown, leading to a significant proplatelet formation (PPF) defect. PMID: 29176689
2. Cortactin expression in carcinoma cells, along with its established involvement in the EGFR pathway, suggests its potential as a therapeutic target for laryngeal squamous cell carcinoma. PMID: 28885660
3. Cortactin depletion in HMEC-1 cells results in increased stress fiber contractility and endothelial barrier destabilization. The secretion of adrenomedullin, a barrier-stabilizing hormone that activates Rap1 and counteracts actomyosin contractility, was reduced in supernatants of cortactin-depleted endothelium. These findings indicate that cortactin regulates actomyosin contractility, ultimately influencing endothelial barrier integrity. PMID: 27357373
4. Research indicates that cortactin-mediated p21Cip1 nuclear export and degradation facilitates MCP1-induced human aortic smooth muscle cell (HASMC) proliferation. PMID: 27363897
5. Mena(INV) promotes invadopodium maturation by inhibiting the normal dephosphorylation of cortactin at tyrosine 421 by the phosphatase PTP1B. PMID: 27824079
6. CTTN expression increases EGFR protein levels and enhances the activation of the MAPK signaling pathway. Furthermore, CTTN expression inhibits the ubiquitin-mediated degradation of EGFR by suppressing the coupling of c-Cbl with EGFR. PMID: 27903975
7. A study revealed that PTBP1 facilitates colorectal cancer migration and invasion activities through the inclusion of cortactin exon 11. PMID: 28404950
8. Research suggests that p27 directly promotes cell invasion by facilitating invadopodia turnover via the Rac1/PAK1/Cortactin pathway. PMID: 28287395
9. Tyrosine dephosphorylation of the cytoskeletal scaffold, cortactin, recruits the RhoA antagonist SRGAP1 to relax adherens junctions in response to HGF. PMID: 28983097
10. Cortactin binds to E-cadherin, and RhoA-induced phosphorylation by protein kinase D1 (PKD1; also known as PRKD1) at S298 impairs adherens junction assembly and supports their dissolution. PMID: 27179075
11. PBF plays a unique role in regulating CTTN function, promoting endocrine cell invasion and migration. PMID: 27603901
12. AMPK phosphorylation of cortactin followed by SIRT1 deacetylation modulates the interaction between cortactin and cortical-actin in response to shear stress. This AMPK/SIRT1 coregulated cortactin-F-actin dynamics is required for endothelial nitric oxide synthase subcellular translocation/activation and exhibits atheroprotective effects. PMID: 27758765
13. Evidence suggests that cortactin promotes exosome secretion by stabilizing cortical actin-rich multivesicular late endosome docking sites. PMID: 27402952
14. Cortactin may play a significant role in the development of oral tumors in humans. PMID: 27148699
15. A dynamic TIP150-cortactin interaction orchestrates directional cell migration by coupling dynamic microtubule plus ends to the cortical cytoskeleton. PMID: 27451391
16. Amplification of 11q13, resulting in overexpression of CTTN/CCND1, was the most prominent finding, observed in 13 out of 19 ESCC cases. PMID: 27877079
17. The cortactin Tyr421 residue is required to promote cell proliferation both in vitro and in vivo. PMID: 27805253
18. The expression of CTTN, Exo70, and MMP-9 in HCC cells was detected, and their relationship with the ability of migration and invasion of hepatoma carcinoma cells was evaluated. PMID: 27025610
19. miR-542-3p inhibits the invasion of colorectal cancer cells by targeting CTTN. PMID: 26952924
20. Cortactin expression in epithelial ovarian carcinoma was closely related to malignant biological behavior. PMID: 26243395
21. MCP1-induced cortactin phosphorylation is dependent on PLCb3-mediated PKC activation, and siRNA-mediated down-regulation of either of these molecules prevents cortactin interaction with WAVE2. PMID: 26490115
22. Findings reveal that Keap1 regulates cell migration by affecting the subcellular localization and activity of cortactin independently of its role in oxidant stress responses. PMID: 26602019
23. Host cortactin, PKD1, and actin are recruited by Trypanosoma cruzi extracellular amastigotes, as demonstrated by experiments in fixed and live cells using time-lapse confocal microscopy. PMID: 26096820
24. A study highlights the potential role of CCM3 in regulating tight junction complex organization and brain endothelial barrier permeability through CCM3-ERK1/2-cortactin cross-talk. PMID: 26385474
25. Researchers identified and confirmed that Fra-1 affected the expression level of CTTN and EZR in vitro through LC-MS/MS analyses and western blot technology. PMID: 26330014
26. Acetylation-mimicking mutants of alpha-tubulin and cortactin counteract HDAC6-induced ciliary disassembly. PMID: 26246421
27. Cortactin is crucial for the invasion and migration of glioma cells, potentially promoting their migration and invasion by regulating lamellipodia formation, a process requiring the combination of cortactin and the Arp2/3 complex. PMID: 26238396
28. Findings demonstrate that CTTN is significantly upregulated in colon cancer, and its ectopic expression promotes cell proliferation and tumorigenicity through EGFR-ERK pathway regulation, suggesting that CTTN plays a critical role in colon cancer progression. PMID: 26151562
29. Results indicate that cortactin is involved in the regulation of apoptosis induced by VacA in gastric cells. PMID: 26289258
30. The study investigated the expression of cortactin in HCT116 cells treated with one of the major components of Chansu, Cinobufagin. PMID: 26134506
31. These findings suggest that this common cortactin variant may functionally contribute to ALI predisposition by impeding endothelial wound healing. PMID: 26361873
32. Data suggests a model in which phosphatidylinositol 3,5-bisphosphate binding removes cortactin from late endosomal branched actin networks, promoting net actin turnover. PMID: 26323691
33. Dysregulation of cortactin and HDAC6 is implicated in the invasiveness and migration of prostate cancer cells. PMID: 26112958
34. These results imply that MTSS1 suppresses cell migration and invasion by inhibiting the expression of CTTN and serves as a prognostic biomarker in Glioblastomas. PMID: 25385572
35. Upregulation of CTTN is critical for Vascular endothelial growth factor-C-mediated tumor growth and metastasis of esophageal squamous cell carcinoma. PMID: 25212831
36. The cortactin SH3 domain contributes to podosome assembly, while fascin actin bundling is a master regulator of podosome disassembly in THP-1 macrophages and dendritic cells. PMID: 25601713
37. Integrated omic analysis of oropharyngeal carcinomas reveals human papillomavirus-dependent regulation of the AP-1 pathway and elevated cortactin protein levels. PMID: 25271301
38. This review focuses on recently published evidence that endothelial ABPs, such as cortactin, myosin, or alpha-actinin, regulate leukocyte extravasation by controlling actin dynamics, biomechanical properties of endothelia, and signaling pathways. PMID: 25848070
39. c-src-mediated phosphorylation requires RTPAalpha. PMID: 24652832
40. Cortactin, another player in the Lyn signaling pathway, is over-expressed and alternatively spliced in leukemic cells from patients with B-cell chronic lymphocytic leukemia. PMID: 24532043
41. Cortactin expression promoted the migration, invasion, and proliferation of SGC-7901 cells both in vivo and in vitro. PMID: 24696610
42. Mechanistic investigations showed that VEGF-C increased CTTN expression by downregulating Dicer-mediated maturation of miR326, thereby relieving the suppressive effect of miR326 on CTTN expression. PMID: 25205106
43. The association of cortactin with Pfn-1 is regulated by c-Abl-mediated cortactin phosphorylation. PMID: 24700464
44. Data suggests that curcumin is an activator of non-receptor type 1 protein tyrosine phosphatase (PTPN1) and can reduce cell motility in colon cancer via dephosphorylation of pTyr(421)-cortactin (CTTN). PMID: 24465712
45. Overexpression of cortactin (CTTN) was observed in 126/198 (63.6%) of esophageal squamous cell carcinoma cases and was significantly associated with lymph node metastasis (P = 0.000), pathologic stage (P = 0.000), and poor survival (P<0.001). PMID: 24551190
46. Studies show that bladder cancer cells with cortactin knockdown have a reduced capacity to extravasate into the lung from the circulation, due to the decreased invasive character of invadopodia. PMID: 24549769
47. Studies show that IQGAP1 functions as a hub linking HGF-induced signaling to microtubules and actin remodeling via EB1-IQGAP1-cortactin interactions. PMID: 25022754
48. Expression of a charge-neutralizing cortactin mutant inhibited contraction and actin dynamics during contractile activation. PMID: 24920679
49. Two amino acid residues confer different binding affinities of Abelson family kinase SRC homology 2 domains for phosphorylated cortactin. PMID: 24891505

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HGNC: 3338

OMIM: 164765

KEGG: hsa:2017

UniGene: Hs.596164