Phospho-DPYSL2 (Thr514) Antibody

1. A study found that the interplay between distinct CRMP2 posttranslational modifications is a key factor in determining the trafficking and localization of NaV1.7. (PMID: 27940916)
2. The crystal structure of human tetrameric CRMP-2 has been elucidated. (PMID: 28044206)
3. Elevated levels of phosphorylated CRMP2 (pCRMP2) may be a contributing factor to the axonal pathology observed in Lewy body dementias. (PMID: 27609071)
4. Research indicates that CDK5 activation induces CRMP2A phosphorylation in the nuclei of tumor cells, suggesting a novel oncogenic mechanism. (PMID: 26555036)
5. Polymorphisms in the DPYSL2 gene in humans might be associated with the development of schizophrenia. (PMID: 25847191)
6. Functional variants in the DPYSL2 sequence increase the risk of schizophrenia and suggest a link to mTOR signaling. (PMID: 25416705)
7. Alterations in CRMP2, TCP1epsilon, TPM2, and 14-3-3gamma were confirmed in experimental tumors and in a series of 28 human SI-NETs. (PMID: 25224486)
8. Reduced CRMP2 expression and elevated expression of nuclear phosphorylated CRMP2 may be associated with breast cancer progression. (PMID: 23381229)
9. Levels of total GSK3 were decreased in the Huntington disease-affected frontal cortex, which correlated with decreased phosphorylated CRMP2. (PMID: 24634145)
10. High dihydropyrimidinase-related protein 2 expression is associated with lung cancer. (PMID: 24518087)
11. Genetic variants in DPYSL2 may play a role in susceptibility to alcohol dependence. (PMID: 23846846)
12. A specific and reversible intermolecular Cys-504-Cys-504 dithiol-disulfide switch in homotetrameric CRMP2 determines two conformations of the quaternary CRMP2 complex, which controls axonal outgrowth and neuronal development. (PMID: 24133216)
13. CRMP-2-dependent regulation of ROCK II activity is mediated through interaction of the CRMP-2L N terminus with the ROCK II catalytic domain and by GSK3-dependent phosphorylation of CRMP-2. (PMID: 24036111)
14. A novel regulatory mechanism utilizing CRMP2 SUMOylation orchestrates NaV1.7 trafficking. (PMID: 23836888)
15. Research provides insight into CRMP-2 as a controller of myosin II-mediated cellular functions through the inhibition of ROCK II in nonneuronal cells. (PMID: 22431514)
16. No Alzheimer disease-associated differences in CNP and DPYSL2 promoter DNA methylation were observed. (PMID: 22954668)
17. Deletion analysis of CRMP-2 identified a 51 amino acid sequence in the C-terminus that is required for targeting to the basal body and primary cilium. This domain contains GSK-3beta phosphorylation sites. (PMID: 23185275)
18. High levels of nuclear phosphorylated CRMP-2 are associated with lung cancer. (PMID: 23023514)
19. CRMP2 hyperphosphorylation is specific to Alzheimer's disease and is not a common event in all forms of dementia and neurodegeneration, particularly other tauopathies. (PMID: 21860090)
20. Findings suggest a significant role of phosphorylated CRMP-2 in process retraction induced by reactive oxygen species. (PMID: 22443207)
21. HTLV-1 has the ability to influence the CRMP2/PI3K/Akt axis, positively controlling cytoskeleton organization and lymphocyte migration. (PMID: 22227566)
22. CRMP2 regulates dendritic projection, and phosphorylation of CRMP2 at Ser522 is essential for proper dendritic field organization, axonal guidance, and spine development. (PMID: 22279220)
23. This review discusses the essential biology of CRMP2 in the context of emerging data that implicates CRMP2 perturbations as either a correlate of or a potential contributor to diverse neuropathologies. (PMID: 21271304)
24. Data support DPYSL2 and the surrounding genomic region as a susceptibility locus for schizophrenia. (PMID: 21302347)
25. Research provides the first trafficking regulatory role for Crmp2 in non-neuronal cells, supporting a model where Crmp2 is a crucial endocytic regulatory protein that links MICAL-L1.EHD1-based vesicular transport to dynein motors. (PMID: 20801876)
26. DPYSL2 does not have a major function in schizophrenia in Japanese subjects. (PMID: 20414250)
27. CRMP2, as a direct tubulin binder, may function as a GTPase-activating protein (GAP) of tubulin during neurite formation, and its GAP activity might be regulated by an intramolecular interaction with an N-terminal inhibitory region. (PMID: 19666111)
28. Aberrant expression of dihydropyrimidinase related proteins-2,-3, and -4 was observed in fetal Down syndrome brain. (PMID: 11771764)
29. No significant associations were found between five polymorphisms of the DRP-2 gene and Bipolar Disorder, nor were associations detected between either of the polymorphisms and bipolar subtypes I and II. (PMID: 12951196)
30. Research shows that glial cell line-derived neurotrophic factor (GDNF) enhances CRMP-2 expression in TGW human neuroblastoma cells through activation of the RET receptor tyrosine kinase. (PMID: 15207709)
31. A significant decrease in crmp-2 protein may represent or underlie impaired neuronal plasticity, neurodegeneration, and brain wiring in mesial temporal lobe epilepsy. (PMID: 15672539)
32. CRMP-2 transports the Sra-1/WAVE1 complex to axons in a kinesin-1-dependent manner, regulating axon outgrowth and formation. (PMID: 16260607)
33. Collapsin response mediator protein-2 (CRMP-2) transcriptional activity is inhibited by all-trans-retinoic acid during SH-SY5Y neuroblastoma cell differentiation. (PMID: 17229153)
34. Findings indicate that hyperphosphorylation of CRMP2 is an early event in the development of Alzheimer's Disease and suggest it can be induced by severe APP over-expression or processing defects. (PMID: 17683481)
35. Results suggest that CRMP-2 may be a novel colorectal cancer biomarker. (PMID: 18203259)
36. The association of neurofibromin and CRMP-2 is essential for neuronal cell differentiation. (PMID: 18218617)
37. Relative resistance to phosphatases might be a common feature of Cdk5 substrates and could contribute to the hyperphosphorylation of CRMP2 and Tau observed in Alzheimer's disease. (PMID: 18460467)
38. Data indicate that collapsin response mediator protein-2 (CRMP-2) is a novel calmodulin-binding protein and that CaM binding may play a crucial role in regulating CRMP-2 functions. (PMID: 19151921)
39. Given that CRMP-2 is a key regulator of axon elongation, this interference with cytoplasmic dynein function by CRMP-2 might have a significant role in axon formation and neuronal development. (PMID: 19659462)
40. A significant association was found between a single nucleotide polymorphism of the DRP-2 gene and schizophrenia in a North American sample. (PMID: 15858820)

Show More

Hide All

HGNC: 3014

OMIM: 602463

KEGG: hsa:1808

STRING: 9606.ENSP00000309539

UniGene: Hs.593187