Phospho-ESR2 (S105) Antibody

• A study in a Mexican population revealed an association between the rs1256032 polymorphism of the estrogen receptor beta gene and a reduced risk of developing type 2 diabetes. PMID: 29666032
• Researchers identified a homozygous ESR2 variant, c.541_543del p.(Asn181del) in the highly conserved DNA-binding domain of ER-beta, in an individual with syndromic 46,XY DSD. Additionally, two heterozygous missense variants, c.251G>T p.(Gly84Val) and c.1277T>G p.(Leu426Arg), located in the N-terminus and the ligand-binding domain of ER-beta, were found in unrelated, nonsyndromic 46,XY DSD cases. PMID: 29261182
• Therapeutic activation of ERbeta demonstrates potent anticancer effects in Triple-negative breast cancer by inducing a family of secreted proteins known as cystatins. These cystatins inhibit canonical TGFbeta signaling and suppress metastatic phenotypes both in vitro and in vivo. PMID: 30257941
• Analysis of ESR2 polymorphisms indicated minimal influence on bone mineral density changes in women. PMID: 29320918
• Low ESR2 expression has been linked to tumor progression in Colorectal Cancer with Familial Adenomatous Polyposis and Sporadic Polyps. PMID: 28681123
• The ESR2 G1730A variant is being investigated as a potential risk factor for Myocardial Infarction (MI) at a young age. PMID: 30036658
• TCF21 modulates Steroidogenic factor-1 and estrogen receptor beta expression through the recruitment of USF2 in endometriotic stromal cells. PMID: 30018006
• Elevated phosphorylated ESR2 expression is associated with pancreatic ductal adenocarcinoma. PMID: 30046904
• FSHR rs6165, rather than ESR2 rs4986938, is suggested as a potential marker for predicting poor ovarian response. PMID: 29036809
• A significant association was observed between ERbeta RsaI and postmenopausal osteoporosis risk, particularly in both overall and Asian populations. PMID: 29458346
• Estrogen receptor beta1 activation accelerates resistance to epidermal growth factor receptor-tyrosine kinase inhibitors in non-small cell lung cancer. PMID: 29328407
• Increased cytoplasmic ERbeta1 and nuclear ERbeta2 expression is associated with poorer cancer-specific outcomes following radical prostatectomy. These findings suggest that tumor ERbeta1 and ERbeta2 staining patterns provide prognostic information for patients treated with radical prostatectomy. PMID: 26804755
• ESR2 single nucleotide polymorphism is associated with poor ovarian response in Egyptian women undergoing IVF procedures. PMID: 28825151
• ERbeta expression conferred cell sensitivity, as patient-derived AML cells with high levels of ERb were sensitive to diosmetin, while cells with low ERb were insensitive. Knockdown of ERb confirmed resistance, whereas overexpression enhanced sensitivity to diosmetin, which was demonstrated to be mediated by reactive oxygen species signaling. PMID: 28835383
• Research reports for the first time that ERbeta inversely regulates miR-10b and miR-145, which are critical modulators of functional properties, epithelial to mesenchymal transition, and extracellular matrix composition of breast cancer cells. ERbeta, along with miR-10b and miR-145, are key players in the initiation of breast cancer cell aggressiveness. PMID: 28797712
• The mRNA expression levels of ERbeta isoforms are downregulated in sporadic colorectal cancer and in FAP individuals. T3/T4 tumors also exhibit decreased expression of ERbeta. Additionally, the expression levels of ERbeta1 and ERbeta5 were associated with the probability of disease-free survival. PMID: 29132333
• Factors that regulate the alternative splicing of ERs remain unknown. Novel evidence suggests a potential biological feedback loop where 17beta-estradiol regulates the RNA-binding protein Nova1, which, in turn, regulates the alternative splicing of ERbeta. PMID: 29031089
• A dual role of the association between AGO2 and ERbeta in luminal-like breast cancer cells in the nucleus and cytoplasm for the regulation of gene expression at both the transcriptional and post-transcriptional level. PMID: 29017520
• Researchers found higher nuclear (n)ERalpha and nERbeta5 and lower cytoplasmic (c)ERalpha expression in advanced ovarian cancers. Lower ERbeta1 expression was also detected in high-grade cancers. Loss of nERalpha and cERbeta2 expression was observed in clear cell histological subtypes. Higher nERbeta5 and lower cERbeta5 expression were associated with serous/clear cell subtypes, poor disease-free, and overall survival. PMID: 28859612
• There was minimal overall difference in the DNA methylation of the ESR2 5'-flanking region in individuals with autism compared with normal individuals. PMID: 28299627
• Data reveal a novel mechanism for ERbeta's anti-proliferative and pro-apoptotic effects in breast cancer cells involving p53 and epigenetic changes in histone methylation that underlie gene regulation of these cellular activities. PMID: 28577282
• Loss of ERbeta function acts in collaboration with p53 inactivation to induce early onset of mammary tumors with spindle cell morphology and more basal-like characteristics. PMID: 28673316
• Low levels of ESR2 are associated with metastasis in triple-negative breast cancer. PMID: 28583190
• Findings from the systematic review and meta-analysis suggest that rs1256120 of ESR2 is unlikely to be a predisposing or disease-modifying genetic risk factor for adolescent idiopathic scoliosis. PMID: 27755497
• High concentrations of DINCH urinary metabolites activate human ESR2 receptors. PMID: 29421333
• Tumor ERbeta1 expression was available for 911 breast cancer patients and was not associated with ESR2 genotypes. High tumor ERbeta1 expression is a marker of good prognosis in breast cancer, especially among chemotherapy-treated patients, but not in endocrine therapy-treated patients. PMID: 27810901
• Targeting ERbeta with selective agonists might affect Hodgkin's lymphoma cell proliferation and tumor growth via a mechanism involving DRAM2-dependent autophagic cascade. PMID: 28052027
• ERbeta might be the target protein of arctigenin responsible for inhibiting mTORC1 activation and, consequently, preventing Th17 cell differentiation and colitis development. PMID: 27863380
• Data suggest that the ERalpha-H19-BIK signaling axis plays a significant role in promoting breast cancer cell chemoresistance. PMID: 27845892
• Fulvestrant upregulated ERbeta in ERalpha+/ERbeta+ breast cancer and in triple-negative ERbeta+ breast cancers (ERalpha-/ERbeta+). PMID: 27486755
• ERbeta plays a crucial role in the cell behavior and extracellular matrix composition of the highly aggressive MDA-MB-231 cells. PMID: 27179695
• A study provides evidence for a critical role of ESR2 in radioresistance of head and neck squamous cell carcinoma, and that SMR3A might serve as a surrogate marker for active ESR2 signaling. PMID: 28166815
• This study demonstrated that ESR2, but not ESR1 minor alleles, were associated with lower cognitive performance in elderly women with an indication of a gene-gene interaction with APOEepsilon4. It also found indications for gene-environment interactions of ESR2 with traffic-related air pollution exposure on cognitive performance. PMID: 27629499
• LY500307 is a highly selective estrogen receptor beta agonist. However, it loses its selectivity at high doses and leads to undesirable suppression of total testosterone concentration. PMID: 27136911
• ERbeta ubiquitination, protein turnover, and inhibition of breast cancer are regulated by tyrosine phosphorylation. PMID: 27323858
• ERbeta in both normal and cancerous colon epithelial cells upregulates miRNA-205, which subsequently reduces PROX1 through direct interaction with its 3'UTR. PMID: 27283988
• Membrane estrogen receptor beta and GPER signaling mediate cellular responses to environmentally relevant concentrations of CdCl2 and NaAsO2 in lung adenocarcinoma cells. PMID: 27071941
• C-Jun and CREB are recruited to ESR2 or CYP19A1 promoter by IGF-I stimulation. PMID: 26899323
• Increases in ERbeta and p53 immunoreactivity were significantly correlated with the incidence of metastasis and/or recurrence in endometrial endometrioid carcinoma. PMID: 29190668
• Low estrogen receptor beta is associated with triple-negative breast cancer. PMID: 26871946
• The variation at rs10144225 in ESR2 was associated with salt-sensitive blood pressure (SSBP) in premenopausal women (estrogen-replete) but not in men or postmenopausal women (estrogen-deplete). Inappropriate aldosterone levels on a liberal salt diet may mediate the SSBP. PMID: 28938457
• Data suggest that 17-beta-estradiol/ESR2 signaling counteracts TNFA-induced, inflammation-mediated apoptosis of vascular endothelial cells in a mechanism that requires NOTCH1-mediated Akt phosphorylation. (ESR2 = estrogen receptor 2; TNFA = tumor necrosis factor-alpha; NOTCH1 = Notch homolog 1, translocation-associated protein) PMID: 28893903
• Expression of ERbeta and p53 significantly correlated with age and advanced cancer stages, and p53-negative EOGC was associated with favorable outcomes. PMID: 27781410
• Our data suggest that estrogens stimulate osteogenic differentiation in human dental pulp cells, and this action is mediated principally through the ERbeta isoform. PMID: 29031686
• ESR2 may modify the interaction between negative life events and Major Depressive Disorder (MDD) in Chinese Han menopausal females. PMID: 27814959
• Results show that ERb is upregulated in bladder malignant tissue, and its expression is associated with muscle-invasive disease. PMID: 27324053
• Estrogen may play a role in androgen-independent prostate cancer cell proliferation through a novel pathway involving ERbeta-mediated activation of beta-catenin. PMID: 27107935
• ERbeta immunoreactivity was markedly present in all the cases of Merkel cell carcinoma examined. A significant correlation with Ki-67 labeling index and Bcl-2 score suggests that ERbeta could be associated with the regulation of both cell proliferation and apoptosis in MCCs. PMID: 27343835
• Germline ESR2 mutation is associated with medullary thyroid carcinoma. PMID: 26945007
• Exposure to the combination of 100 muM genistein and 10 nM calcitriol reduced the number of proliferative cells to control levels, increased ERb and VDR expression, and reduced extracellular acidification (40%) as well as respiratory activity (70%), primarily in MG-63 cells. Strong overexpression of SGPL1, which irreversibly degrades sphingosine-1-phosphate, thereby generating ethanolamine. PMID: 28125641

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HGNC: 3468

OMIM: 601663

KEGG: hsa:2100

STRING: 9606.ENSP00000343925

UniGene: Hs.660607