Phospho-EZR (Thr567) Antibody

1. Detection of Ezrin and E-cadherin expression in cervical smears has the potential to serve as a prognostic marker for identifying cervical lesions with a high risk of progression to invasive cervical cancer. This marker could aid in selecting appropriate therapy and avoid unnecessary treatment. PMID: 29587669
2. Ezrin and myosin II play critical roles in enhancing line tension by promoting the formation of an actomyosin ring. PMID: 28643776
3. Research suggests that baicalein inhibits the proliferation, migration, and invasion of Osteosarcoma (OS) cells while inducing apoptosis. This effect is mediated by activating the miR183/Ezrin pathway, revealing a novel mechanism underlying the antiOS effects of baicalein. PMID: 29845278
4. Ezrin-anchored PKA phosphorylates serine 369 and 373 on connexin 43, enhancing gap junction assembly, communication, and cell fusion. PMID: 29259079
5. High Ezrin expression is correlated with osteosarcoma. PMID: 29656060
6. L1CAM promotes esophageal squamous cell carcinoma tumorigenicity by upregulating ezrin expression. PMID: 28939985
7. This study is the first to verify the relationship between the expression of RhoA and Ezrin proteins in vaginal tissue of Postmenopausal atrophic vagina. PMID: 28843271
8. Ezrin facilitates AQP2 endocytosis, thereby connecting the dynamic actin cytoskeleton network with AQP2 trafficking. PMID: 28754689
9. FUT4/LeY plays a crucial role in TAMs-mediated EMT. This process might be associated with the up-regulation of Ezrin phosphorylation by FUT4/LeY-mediated fucosylation. PMID: 28423676
10. CPI-17 drives Ras activity and tumorigenesis in melanomas in a two-fold manner: inactivation of the tumor suppressor merlin and activation of the growth-promoting ERM family. PMID: 27793041
11. Data suggest that EGF (epidermal growth factor) induces colorectal cancer cells to undergo epithelial-mesenchymal transition, enhancing their ability to invade/migrate, and promoting phosphorylation of Ezrin at Tyr353. PMID: 28535417
12. Binding of phosphatidylinositol 4,5-biphosphate to ezrin induces a conformational change that allows the insertion of the LOK C-terminal domain to wedge apart the membrane and F-actin-binding domains of ezrin. The N-terminal LOK kinase domain can then access a site 40 residues distal from the consensus sequence, collectively directing phosphorylation of the appropriate threonine residue. PMID: 28430576
13. The expression pattern and subcellular localization of ezrin and moesin correlate with clinicopathological variables such as patients' age, tumor grade, and hormonal status. PMID: 28624994
14. Ezrin represents a promising target for developing strategies aimed at preventing the progression of cervical cancer. PMID: 26933912
15. Ezrin S66 phosphorylation enhances filopodia formation, contributing to the regulation of invasion and metastasis of esophageal squamous cell carcinoma cells. PMID: 28504189
16. These findings reveal a supportive role of ERMs in cortical activities during cytokinesis, and also provide insight into the selective mechanism that preferentially associates cytokinesis-relevant proteins with the division site. PMID: 28889652
17. Ezrin protein expression is a promising biomarker for estimating the outcome of stage II colorectal cancer patients. When combined with microsatellite status, its ability to predict disease outcome is further enhanced. PMID: 28953975
18. Ezrin is down-regulated during cholangiocarcinogenesis, and its loss results in a more aggressive phenotype. PMID: 26791814
19. A signature of ezrin-interacting proteins accurately predicts esophageal squamous cell carcinoma patient survival or tumor recurrence. PMID: 28603065
20. The results of this meta-analysis suggest that ezrin positive immunoexpression confers a higher risk of recurrence and worse survival in osteosarcoma patients. PMID: 23805177
21. PM blebbing triggered SRF-mediated up-regulation of the metastasis-associated ERM protein Ezrin. Notably, Ezrin is sufficient and important to sustain bleb dynamics for cell-in-cell invasion when SRF is suppressed. PMID: 28774893
22. EZR is a novel biomarker in terms of invasion among the 3 subtypes of NFPAs, and it is a promising guide for therapeutic decision-making as well. PMID: 28093347
23. Increased ezrin and HER2 expression in patients with salivary gland carcinomas represents a high-grade histopathological subtype. PMID: 28300573
24. SMYD3 enhances tumorigenicity in esophageal squamous cell carcinoma by enhancing transcription of ezrin and LOXL2, which are involved in proliferation, migration, and invasion. PMID: 26980013
25. 3-dimensional cell cultures were found to mimic different tumor sites and be applicable as a model. The in vitro results concur with the clinical specimen analysis, suggesting that in ovarian carcinoma, the role of ezrin in disease progression is more pronounced than that of p130Cas. PMID: 27622508
26. The expression of ezrin was up-regulated and significantly associated with the stage, lymph node involvement, and distant metastasis. PMID: 28261953
27. There were significant decreases in intercellular adhesion molecules 1 (ICAM1), ezrin (EZR), mitogen-activated protein kinase kinase 2 (MAP2K2), and nitric oxide synthase 3 (NOS3) gene expressions in metabolic syndrome patients. PMID: 26956845
28. Immunohistochemistry staining for ezrin was similar in AFX and UPS tumors. PMID: 28079637
29. Ezrin and HER2/neu are overexpressed and coexpressed in osteosarcoma with adverse prognostic features such as high grade. Therefore, ezrin and HER2/neu could be potential prognostic markers and treatment targets for osteosarcoma. PMID: 26067138
30. The study indicates that the usual relationship between estrogen and ezrin induction is abridged. The study suggests that changes in ezrin may be associated with the development of the invasive phenotype and penetration of the basement membrane. PMID: 27688241
31. The present study showed over-expression of ezrin and moesin in colorectal carcinoma. PMID: 27042764
32. The study indicates that the presence of autoantibodies against Ezrin is significantly associated with ESCC. PMID: 28298808
33. Ezrin protein is highly expressed in human PHC tissue, which can be used for the prediction of metastatic disease. PMID: 28230040
34. The results show that the activation of the ezrin-pAkt signaling axis is associated with the more aggressive clinicopathological features of PPA compared with LPA. PMID: 27059464
35. Ezrin and p65 interactions in MDA-MB-231 cells were confirmed using co-immunoprecipitation. PMID: 27420986
36. The study investigates the distribution of NHERF1 in ovarian cancer and reveals a different regulation of NHERF1 and EZRIN expression in ovarian tumors, representing the complexity of the molecular changes in this disease. PMID: 27823775
37. Phosphorylation of ezrin, along with its binding to phosphatidylinositol-4,5-bisphosphate, tethers the F508del CFTR to the actin cytoskeleton, stabilizing it on the apical membrane and rescuing the sub-membrane compartmentalization of cAMP and activated PKA. PMID: 26823603
38. Data show that gene silencing of ezrin inhibits the proliferation and invasion of prostate cancer PC-3 cells, while the level of E-cadherin is upregulated and N-cadherin is downregulated. PMID: 27371852
39. Knockdown of ezrin in HUVECs significantly induced morphogenetic changes and cytoskeletal reorganization of the transfected cells, and also reduced cell migration and angiogenesis capacity in vitro. PMID: 27072970
40. High EZRIN expression is associated with prostate cancer. PMID: 26799186
41. Elevated Ezrin expression is associated with a poor prognosis in a variety of solid tumors. PMID: 26632332
42. These findings suggest that ezrin-EGFR interaction augments oncogenic functions of EGFR and that targeting ezrin may provide a potential novel approach to overcome erlotinib resistance in non-small cell lung cancer cells. PMID: 26936397
43. The value of ezrin expression as a prognostic biomarker is further consolidated in urothelial cancer. PMID: 25278252
44. The study suggests a role for ezrin in advanced glycation end product-induced podocyte damage. PMID: 26032400
45. Phospho-Ezrin/Radixin/Moesin (ERM) inhibit cell adhesion, and therefore, dephosphorylation of ERM proteins is essential for cell adhesion. Phospho-ERM induce formation and/or maintenance of spherical cell shape. PMID: 26555866
46. Activation of liver PKCs during cholestasis leads to Ezrin Thr567 phosphorylation, resulting in MRP2 internalization and degradation where ubiquitin ligase E3 GP78 is involved. PMID: 26212029
47. Data indicate that a quinoline-based small molecule, NSC305787, directly binds to ezrin and inhibits its functions. PMID: 26358752
48. We identified and confirmed that Fra-1 affected the expression level of CTTN and EZR in vitro through LC-MS/MS analyses and western blot technology. PMID: 26330014
49. Data show that both Ezrin and SIX1 proteins are highly expressed in alpha fetoprotein-negative hepatocellular carcinoma (HCC) and significantly related with the TNM stage. PMID: 26927385
50. It was found that expression of miR-96 was negatively correlated with the metastatic ability of renal cell carcinoma, and that downregulation of miR-96 could suppress the invasion of renal cancer cells via downregulation of Ezrin expression. PMID: 26419932

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HGNC: 12691

OMIM: 123900

KEGG: hsa:7430

STRING: 9606.ENSP00000338934

UniGene: Hs.487027