Phospho-HIST1H1D (T146) Antibody
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In Stock 
Product Specs
Buffer
**Preservative:** 0.03% Proclin 300
**Constituents:** 50% Glycerol, 0.01M PBS, pH 7.4
**Constituents:** 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Lead Time
Typically, we can ship your order within 1-3 business days of receiving it. Delivery times may vary depending on the shipping method and destination. Please contact your local distributor for specific delivery time estimates.
Synonyms
Histone H1.3 (Histone H1c) (Histone H1s-2), HIST1H1D, H1F3
Target Names
HIST1H1D
Uniprot No.
Target Background
Function
Histone H1 protein binds to linker DNA between nucleosomes, forming the macromolecular structure known as the chromatin fiber. Histones H1 are essential for the condensation of nucleosome chains into higher-order structured fibers. They also function as regulators of individual gene transcription through chromatin remodeling, nucleosome spacing, and DNA methylation.
Gene References Into Functions
- Studies have shown that histone H1.3 was exclusively identified in non-neoplastic MCF-10A breast cells, but not in metastatic MDA-MB-231 breast cancer cells. PMID: 26209608
- Histone H1 organizes and maintains an extensive protein-protein interaction network within the nucleolus, which is crucial for nucleolar structure and integrity. PMID: 25584861
- Overexpression of histone cluster 1 has been linked to recurrence in meningiomas. PMID: 20685720
Database Links
Protein Families
Histone H1/H5 family
Subcellular Location
Nucleus. Chromosome. Note=According to PubMed:15911621 more commonly found in euchromatin. According to PubMed:10997781 is associated with inactive chromatin.
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