Phospho-ICK (Y159) Antibody
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Product Specs
Buffer
Liquid in PBS containing 50% glycerol, 0.5% BSA, and 0.02% sodium azide.
Form
Liquid
Lead Time
Typically, we can ship your order within 1-3 business days of receipt. Delivery timelines may vary depending on your location and shipping method. Please consult your local distributor for specific delivery information.
Synonyms
CILK1 antibody; ICK antibody; KIAA0936Serine/threonine-protein kinase ICK antibody; EC 2.7.11.1 antibody; Ciliogenesis associated kinase 1 antibody; Intestinal cell kinase antibody; hICK antibody; Laryngeal cancer kinase 2 antibody; LCK2 antibody; MAK-related kinase antibody; MRK antibody
Target Names
ICK
Uniprot No.
Target Background
Function
Phospho-ICK (Y159) Antibody is essential for ciliogenesis. It phosphorylates KIF3A, a protein involved in controlling ciliary length. This antibody plays a crucial role in regulating the localization of SHH pathway components and IFT components at ciliary tips. Its function extends to regulating intraflagellar transport (IFT) speed and negatively regulating cilium length in a cAMP and mTORC1 signaling-dependent manner. This regulation is dependent on its kinase activity. Phospho-ICK (Y159) Antibody is believed to play a pivotal role in the development of multiple organ systems, particularly cardiac development.
Gene References Into Functions
- Our research suggests that heterozygous variants in ICK are linked to juvenile myoclonic epilepsy in 7% of patients in our study. These variants impact cellular processes, explaining the microdysgenesis and polyspike networks observed on EEG in juvenile myoclonic epilepsy. PMID: 29539279
- Our findings identify ICK as a gene associated with short rib polydactyly syndromes (SRPS) and reveal that disruptions in signaling pathways contribute to skeletal development defects. PMID: 27466187
- Our research suggests that increased ICK expression/activity in response to protein deprivation provides a novel protective mechanism to limit apoptosis and support compensatory mucosal growth under nutritional stress. PMID: 25184386
- The expressions of ICK/MAK/MOK proteins in the intestinal tract can be regulated differentially and dynamically, suggesting a significant functional diversity within this group of protein kinases. PMID: 24244486
- In glioblastoma cells with deregulated high levels of CCRK, depleting CCRK restores cilia through ICK and an ICK-related kinase MAK, thereby inhibiting glioblastoma cell proliferation. PMID: 23743448
- High ICK expression is associated with prostate cancer. PMID: 22761715
- ICK plays a significant role in modulating the activity of mTORC1 through phosphorylation of Raptor Thr-908. PMID: 22356909
- ICK is implicated in the development of multiple organ systems. The R272Q variant has been associated with endocrine-cerebro-osteodysplasia and may explain loss of function, as the R272Q mutant fails to localize at the nucleus and exhibits diminished kinase activity. PMID: 19185282
- Our research demonstrates a significant role for ICK in the proliferation and differentiation of intestinal epithelial cells. PMID: 19696144
- ICK and FBX9 are divergently transcribed from a bidirectional promoter that is GC-rich and contains a CpG island. PMID: 20459822
- PP5 (protein phosphatase 5) and CCRK (cell cycle-related kinase) are yin-yang regulators of T157 phosphorylation. ICK interacts with and phosphorylates human Scythe, an essential regulator of proliferation and apoptosis during mammalian development. PMID: 16954377
- ICK plays a crucial role in regulating the proliferation and differentiation of intestinal epithelial cells. ICK may control G1 cell cycle progression by regulating the expression of cell cycle regulators cyclin D1, c-Myc, and p21Cip1. PMID: 19696144
- ICK is the prototype for a new group of MAPK-like kinases requiring dual phosphorylation at TDY motifs. PMID: 15988018
Database Links
Involvement In Disease
Endocrine-cerebroosteodysplasia (ECO)
Protein Families
Protein kinase superfamily, CMGC Ser/Thr protein kinase family, CDC2/CDKX subfamily
Subcellular Location
Nucleus. Cytoplasm, cytosol. Cell projection, cilium. Cytoplasm, cytoskeleton, cilium basal body.; [Isoform 2]: Cytoplasm.
Tissue Specificity
Expressed in heart, brain, placenta, pancreas, thymus, prostate, testis, ovary, small intestine and colon, with highest levels in placenta and testis. Not detected in spleen. Also expressed in many cancer cell lines.
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