Phospho-IL10RA (Ser319/323) Antibody

1. This case report and case-control study delves into the role of IL10RA and its deficiency in the development of the immune system and inflammatory bowel diseases. PMID: 28644354
2. We identified 32 compound heterozygous mutations and 9 homozygous mutations in IL10 receptor subunit alpha and 1 homozygous mutation in IL10 receptor subunit beta. Among these mutations, 10 novel mutations were identified, and 6 pathogenic mutations had been previously described. In patients with IL10 receptor subunit alpha mutations, c.301C>T (p.R101RW) and c.537 G>A (p.T179T) were the most common mutations. PMID: 28267044
3. These findings provide a novel mechanism by which microbial-derived butyrate promotes barrier integrity through IL-10RA-dependent repression of claudin-2. PMID: 28893958
4. Expression of IL10R subunits within the leukocyte population (CD45(+) cells) was significantly higher in primary brain tumors than in metastases. PMID: 28982901
5. This study revealed no association between schizophrenia and IL10 and IL10RA single polymorphisms and haplotypes. PMID: 27397081
6. The IL-10RA rs9610 A allele was found to be more frequent in rheumatoid arthritis (RA) patients compared to control subjects. Notably, significant differences were observed in both the allele and genotype frequencies of rs9610 between anti-CCP (anti-cyclic citrullinated peptide) positive patients and anti-CCP negative patients. These findings suggest that the IL-10RA rs9610 polymorphism might contribute to RA susceptibility. PMID: 27796662
7. These results indicate that the S138G loss-of-function polymorphism of the IL-10R1 receptor may be a significant risk factor for increased susceptibility to multiple sclerosis. PMID: 28225209
8. The study elucidates the structure of box1 from class II cytokine receptors IFNLR1 and IL10RA bound to the FERM-SH2 domain of human JAK1, identifying a consensus motif for JAK1 interaction. PMID: 27133025
9. A JAK2 inhibitor effectively suppressed a BCL6-dependent IL10RA/JAK2/STAT3 pathway in high-grade B-cell lymphoma. PMID: 27268052
10. This genetic association study conducted in a cohort of infants/children suggests that perianal fistulas are observed in patients with very early-onset inflammatory bowel disease characterized by IL10 receptor mutations (IL10RA/B). The prognosis and response to treatment are generally poor in these cases. PMID: 25373860
11. IL-10Ralpha expression is post-transcriptionally regulated by miR-15a, miR-185, and miR-211 in melanoma. PMID: 26631117
12. The SNP3 polymorphism is associated with myocardial infarction. It is hypothesized that this polymorphism might induce conformational rearrangements within the IL-10R1 receptor domain, affecting IL-10 complex binding and altering downstream signaling. PMID: 24566517
13. High IL10RA expression is linked to diffuse large B-cell lymphoma. PMID: 25733167
14. Inflammatory bowel disease (IBD) in infancy is a distinct disease entity from adult-onset or older child-onset IBD, both phenotypically and genetically. It demonstrates a strong association with the IL-10 receptor gene. PMID: 24785691
15. The IL10R1 loss-of-function A536/S138G polymorphism may contribute to the pathogenesis of recurrent pregnancy loss. PMID: 24689510
16. Very early onset inflammatory bowel disease associated with aberrant trafficking of IL-10R1 has been successfully treated through T cell replete haploidentical bone marrow transplantation. PMID: 24519095
17. Mutations in the IL10RA gene are associated with ulcerative colitis. PMID: 24216686
18. A case report highlights a pediatric patient with ulcerative colitis carrying a novel point mutation within the IL10RA promoter (the -413G->T), inherited from his mother. PMID: 24379584
19. This report provides further evidence of the genetic defect of IL-10RA in neonatal-onset inflammatory bowel disease. PMID: 23839161
20. IFN-gamma selectively induced the expression of IL-10R1 on intestinal epithelia, predominantly on the apical membrane of polarized epithelial cells. PMID: 24367025
21. A mutation in TLR4 (rs4986790) and IL10RA (rs22291130) was significantly associated with Mycobacterium avium subspecies paratuberculosis-positive Crohn's disease patients. PMID: 23455702
22. Five patients with an IL-10R1 or IL-10R2 deficiency developed B-cell non-Hodgkin lymphoma between the ages of 5 and 6 years (with one patient experiencing recurrence). PMID: 24089328
23. IL10RA polymorphisms are associated with ulcerative colitis. PMID: 22550014
24. In the Chinese Han population, missense SNPs within the exons of the IL-10R1 gene do not appear to contribute to the development of systemic lupus erythematosus. PMID: 22652629
25. The results suggest that genetic polymorphisms in TNF and IL10RA genes may influence the association between blood transfusion and NHL risk. PMID: 22649007
26. IL-10R1 is a novel substrate of betaTrCP-containing ubiquitin E3 ligase, representing a novel negative regulatory mechanism that may potentially affect IL-10 function. PMID: 22087322
27. We identified an IL10R variant in one patient, potentially associated with a decreased response to the cytokine. PMID: 22155628
28. The IL-10R1 S138G loss-of-function polymorphism is associated with the development of extrapulmonary tuberculosis risk in Tunisia. PMID: 21553229
29. The haplotype -185/-116 of IL10 receptor alpha in combination with the haplotype -754/-750 of IL10 receptor beta contributed towards mild malaria. PMID: 21814839
30. IL10R1-G330R does not alter surface expression but influences the duration of STAT phosphorylation, suggesting that the position of G330 plays a role in stabilizing the STAT signal. PMID: 21654841
31. Linkage disequilibrium (LD) blocks were formed in IL10 and IL10RA. PMID: 21532858
32. IL-10R1 expression on CD4+ T cells and signaling in PBMCs were down-regulated in lupus nephritis (LN) patients, indicating a potential role for IL-10 and its receptor in the pathogenesis of LN. PMID: 21635228
33. In addition to overall immune health, host genetic factors influence mortality, retinitis progression, and retinal detachment in patients with AIDS and CMV retinitis receiving HAART. PMID: 21396623
34. In the Lebanese population, the loss-of-function allele IL-10R1-S138G (SNP3) is unlikely to provide protection against ulcerative colitis, and both IL-10R1 variants do not correlate with inflammatory bowel disease. PMID: 20186944
35. Individuals carrying the G allele for the -536AG IL-10R1 gene polymorphism exhibited higher systolic and diastolic pressures and IL-10 levels. Additionally, obese individuals carrying the G allele showed an increased waist-to-hip ratio. PMID: 19798061
36. CMV IL-10 forms a disulfide-linked homodimer that binds two sIL-10R1 molecules. PMID: 12093920
37. IL-10 receptor stimulation triggered the rapid translocation of IL-10E1 to the cell nucleus and the activation of TIMP-1 expression in primary human prostate tumor cell lines. PMID: 12496489
38. Abnormal interleukin 10Ralpha expression contributes to the maintenance of elevated cyclooxygenase-2 in non-small cell lung cancer cells. PMID: 12591723
39. This investigation revealed three previously unidentified polymorphisms of IL-10R1 (SNP3, SNP4, and SNP5), two of which result in an amino acid substitution. The substitution in the S138G variant may interfere with the binding of IL-10 to IL-10R1. PMID: 12759436
40. Homozygosity of the IL-10R1 G330R allele is associated with schizophrenia and may contribute to the expression of the disease phenotype in susceptible individuals. PMID: 17066477
41. Genetic variation in IL-10RA/IL-22 genes may play a modulatory role in the outcome of hepatitis C infection. PMID: 17845543
42. The IL-4R Ile50/Ile50 and IL-10R2 G520/G520 and G520/A520 genotypes were found to determine the susceptibility to SLE (systemic lupus erythematosus) in a Chinese population. PMID: 17988330
43. The peripheral blood neutrophils of septic patients constitutively display abundant levels of surface IL-10R1. PMID: 18308712
44. IL-10R is associated with the progression of renal cell carcinoma. PMID: 18344594
45. Data demonstrate a significant relationship between cervical concentrations of IL-10 and single nucleotide polymorphisms in the IL-10 receptor alpha and beta genes. PMID: 18674658
46. The IL-10R1 S138G loss-of-function allele and ulcerative colitis have been reported. PMID: 18800073
47. A variant rs17121510 in the interleukin-10 receptor antagonist (IL-10RA) gene for allele (p = 0.01) and genotype (p = 3.34x10(-4)) may play a role in preterm birth. PMID: 18818748
48. IL-10R1 variants differentially reduce the signaling activity of cmvIL-10. PMID: 19016528
49. Mutations in genes encoding the IL10R subunit proteins were found in patients with early-onset enterocolitis, involving hyperinflammatory immune responses in the intestine. PMID: 19890111
50. The capacity of neutrophils to respond to IL-10, as measured by Stat3 tyrosine phosphorylation, SOCS-3 expression, and modulation of cytokine production, is dependent on the level of IL-10R1 expression. PMID: 11490020

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HGNC: 5964

OMIM: 146933

KEGG: hsa:3587

STRING: 9606.ENSP00000227752

UniGene: Hs.504035