Phospho-KRT8 (Ser432) Antibody

1. KRT8 mRNA and protein levels are elevated in anaplastic thyroid carcinoma. KRT8 protein interacts with annexin A2. PMID: 29443941
2. K8/K18 variants are overrepresented in Chinese patients with non-alcoholic fatty liver disease (NAFLD) and might accelerate liver fat accumulation through insulin resistance. PMID: 28652657
3. Regulation and enhancement of autophagy, accompanied by increased expression of KRT8 and inhibition of KRT8 phosphorylation, contribute to inhibiting oxidative stress-induced epithelial-mesenchymal transition of retinal pigment epithelium cells. PMID: 28045574
4. Histopathological differences between Magnetic resonance-guided high-intensity focused ultrasound (MR-HIFU)-ablated tissue and radiofrequency (RF)-ablated tissue have been demonstrated. CK-8 proved to be a more reliable marker for cell viability assessment than H&E when employed directly after ablation. PMID: 26732321
5. Loss of activating transcription factor 3 (ATF3) in knockout mice promotes the emergence of keratins CK5+CK8+ epithelial cells. PMID: 26522727
6. KRT8 serves as a notochord-specific marker during early intervertebral disc development. PMID: 26910849
7. Data suggest that the filament elongation of both desmin and keratin K8/K18 proceeds in a manner highly similar to that of vimentin. PMID: 27304995
8. New insights into interactions between the nucleotide-binding domain of CFTR and keratin 8 have been uncovered. PMID: 27870250
9. A multicentre study measured UBC((R)) Rapid Test (detecting fragments of cytokeratins 8 and 18 in urine) in bladder cancer patients and healthy controls, focusing on carcinoma in situ (CIS) and high-grade bladder cancer. PMID: 28468590
10. Data show that after siRNA transfection, TGF-beta1 protein levels were decreased, and CK18 proteins were reduced, while CK8 proteins were increased, and TERT protein expression was slightly elevated at 96 h. PMID: 26462837
11. The interplay between Solo protein and keratin 8/keratin 18 filaments plays a critical role in tensile force-induced RhoA activation and subsequent actin cytoskeletal reinforcement in endothelial cells. PMID: 26823019
12. K8/18 filaments provide resistance to apoptosis in granulosa cell tumor cells by hindering FAS expression. PMID: 26911253
13. These metastatic tumors exhibited no detectable expression of CK8/18, E-cadherin, VCAM-1, and ICAM-1. PMID: 26847082
14. Data demonstrate that the loss of epithelial membrane protein 2 (EMP2) is implicated in sphingosylphosphorylcholine (SPC)-induced phosphorylation of keratin 8 (K8) via ubiquitination of protein phosphatase 2 (PP2A) through alpha4 phosphoprotein by caveolin-1 (cav-1). PMID: 26876307
15. The reactivity of rheumatoid arthritis (RA) serum IgG antibodies against K8 was significantly higher compared to healthy controls and systemic lupus erythematosus patients, confirming K8 as a novel autoantigen of RA. PMID: 26277397
16. Variants in highly conserved residues of K8 Lys393Arg (ezetimibe/simvastatin-related) were found in patients experiencing fatal Drug-induced liver injury. PMID: 26286715
17. Keratins 8 and 18 are type II acute-phase responsive genes that are overexpressed in human liver disease. PMID: 24930437
18. In human failing myocardium, where TNF-alpha expression is upregulated, K8/K18 were also ectopically expressed. PMID: 26280121
19. Human KRT8 variants promote acetaminophen-induced hepatotoxicity in mouse models. PMID: 25963979
20. Syndecan-1 is involved in the morphogenesis of the developing tooth crown and cervical loops, and in conjunction with CK8 and vimentin, in the differentiation of preameloblasts and preodontoblasts. PMID: 25120060
21. K8 immunostaining of tissue from lymph node metastasis allows the identification of a sub-group of lymph node-positive breast cancer patients with a highly unfavorable prognosis. PMID: 25724181
22. This is the first instance where intestinal cells have been suggested to be functionally impaired by K8/K18 mutations. PMID: 24915158
23. The study indicates that Piwil2 plays a role in Fas-mediated apoptosis and can affect p53 phosphorylation in tumor cells, revealing a novel mechanism of Piwil2 in apoptosis, and supporting the notion that Piwil2 actively participates in tumorigenesis. PMID: 25113562
24. An increased expression of cytokeratin 8 and a weak expression of calponin in the tunica media of saphenous vein grafts may serve as useful markers for an unfavorable long-term prognosis in coronary artery bypass graft (CABG) patients. PMID: 24338534
25. These data support the concept that CK8 is a significant receptor for Pet on epithelial cells, initiating its cytotoxic effects. PMID: 24327340
26. Parkin may inhibit cell growth, at least partially, by decreasing RPSA expression and inducing phosphorylation of cytokeratin 8/18. PMID: 23990477
27. These findings, along with the emerging role of cell surface CK8 in cancer metastasis, may imply a dual strategy for tumor cell survival in the host. PMID: 24183726
28. CK8 up-regulation might have a functional role in HCV infection and pathogenesis, and its ectopic expression induces apoptosis of SMMC7721 cells. PMID: 24115814
29. This is the first study to demonstrate a down-regulated CK8 expression and the percentage of CK8-positive cell clusters in intervertebral disc degeneration (IDD), based on multiple lines of evidence. PMID: 23801880
30. Compressive loads resulted in phosphorylation and disassembly of CK8 in nucleus pulposus cells. PMID: 24166186
31. A conserved rod domain phosphotyrosine that is targeted by the phosphatase PTP1B promotes keratin 8 protein insolubility and filament organization. PMID: 24003221
32. These results highlight the role of K8/18 in modulating invasion in breast cancer. PMID: 23341946
33. The study reports keratin 8 expression in breast papillomas and papillary carcinoma. PMID: 23327593
34. K8/18 expression can influence the phenotype of epithelial cancer cells at a transcriptional level, supporting the hypothesis that keratins play an active role in cancer progression. PMID: 23449973
35. Keratin variants are expressed in a low percentage of patients with alcoholic cirrhosis and do not influence hepatocellular carcinoma development. PMID: 23078008
36. There is aberrant expression of CK8 in dysplasia, oral submucous fibrosis, and oral squamous cell carcinoma, suggesting CK8 as a surrogate marker of malignant transformation. PMID: 22677743
37. K8 acetylation at Lys-207, a highly conserved residue among type II keratins, is up-regulated upon hyperglycemia and down-regulated by SIRT2. PMID: 23358244
38. A key role of K8/K18 in regulating glucose metabolism in normal and cancerous hepatic cells through differential modulations of mitochondrial hexokinase status and insulin-mediated signaling. PMID: 23164509
39. Fibroblasts derived from various types of malignant tumors stimulate the expression of the luminal marker keratin 8. PMID: 22270320
40. Keratin filaments were assembled from recombinant keratin proteins 8 (K8) and 18 (K18) in the presence of divalent ions (Mg(2+)). PMID: 22853896
41. Keratin 8 phosphorylation regulates keratin reorganization and migration of epithelial tumor cells. PMID: 22344252
42. Results indicate that K8 is present on the cell surface of transformed prostate cancer cell lines, and K8 increased the activity of plasmin approximately fivefold over a 48-h period. K8 also enhanced the plasmin-mediated proteolysis of vitronectin. PMID: 22354665
43. In patients with hemochromatosis, intronic but not exonic K8/K18 variants are associated with liver fibrosis development. PMID: 22412904
44. A moderate positive correlation between proliferation and keratin 8 expression in neoplastic epithelial cells has been observed. PMID: 22379894
45. Previously undescribed K8 variants are associated with cryptogenic hepatitis in a German cohort of patients, potentially predisposing carriers to the development of liver disease. PMID: 22419260
46. Loss of keratin 8 phosphorylation leads to increased oral squamous cell carcinoma progression. PMID: 22114688
47. The study suggests that CK8 is not suitable for the early diagnosis of tongue squamous cell carcinoma. PMID: 21705376
48. The mild KRT8 allele is associated with CFTR-mediated residual chloride secretion among F508del-CFTR homozygotes. PMID: 21548936
49. The study demonstrates the strong expression of CK8 in limbal epithelial basal cells, which is maintained during the differentiation and migration of the limbal cells towards the central corneal epithelium. PMID: 20926822
50. Clumping factor B is capable of binding cytokeratin 8 during infection. PMID: 20817646

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HGNC: 6446

OMIM: 148060

KEGG: hsa:3856

STRING: 9606.ENSP00000293308

UniGene: Hs.533782