Phospho-KRT8 (Ser74) Antibody

1. KRT8 mRNA and protein exhibit upregulation in anaplastic thyroid carcinoma. KRT8 protein binds to annexin A2. PMID: 29443941
2. K8/K18 variants are overrepresented in Chinese NAFLD patients and may accelerate liver fat storage through insulin resistance. PMID: 28652657
3. Regulation and enhancement of autophagy, accompanied by increased expression of KRT8 and inhibition of KRT8 phosphorylation, serve to inhibit oxidative stress-induced epithelial-mesenchymal transition of retinal pigment epithelium cells. PMID: 28045574
4. Histopathological differences between Magnetic resonance-guided high-intensity focused ultrasound (MR-HIFU)-ablated tissue and radiofrequency (RF)-ablated tissue have been demonstrated. CK-8 was found to be a more reliable marker for cell viability assessment than H&E when used directly after ablation. PMID: 26732321
5. Loss of activating transcription factor 3 (ATF3) in knockout mice promotes the emergence of keratins CK5+CK8+ epithelial cells. PMID: 26522727
6. KRT8 acts as a notochord-specific marker during early intervertebral disc development. PMID: 26910849
7. Data indicate that the filament elongation of both desmin and keratin K8/K18 proceeds in a manner highly similar to that of vimentin. PMID: 27304995
8. New insights into interactions between the nucleotide-binding domain of CFTR and keratin 8 have been revealed. PMID: 27870250
9. A multicentre study measuring UBC((R)) Rapid Test (detecting fragments of cytokeratins 8 and 18 in urine) in bladder cancer patients and healthy controls, with a focus on carcinoma in situ (CIS) and high-grade bladder cancer, has been conducted. PMID: 28468590
10. Data show that after siRNA transfection, TGF-beta1 protein level was decreased, CK18 proteins were reduced, while CK8 proteins were increased, and TERT protein expression was slightly elevated at 96 h. PMID: 26462837
11. The interplay between Solo protein and keratin 8/keratin 18 filaments plays a critical role in tensile force-induced RhoA activation and subsequent actin cytoskeletal reinforcement in endothelial cells. PMID: 26823019
12. K8/18 filaments confer resistance to apoptosis in granulosa cell tumor cells by inhibiting FAS expression. PMID: 26911253
13. These metastatic tumors exhibited no detectable expression of CK8/18, E-cadherin, VCAM-1, and ICAM-1. PMID: 26847082
14. Data indicate that loss of epithelial membrane protein 2 (EMP2) is involved in sphingosylphosphorylcholine (SPC)-induced phosphorylation of keratin 8 (K8) via ubiquitination of protein phosphatase 2 (PP2A) through alpha4 phosphoprotein by caveolin-1 (cav-1). PMID: 26876307
15. The reactivity of rheumatoid arthritis (RA) serum IgG antibodies against K8 was significantly higher than in healthy controls and systemic lupus erythematosus patients, confirming K8 as a novel autoantigen of RA. PMID: 26277397
16. Variants in highly conserved residues of K8 Lys393Arg (ezetimibe/simvastatin-related) were found in patients with fatal Drug-induced liver injury. PMID: 26286715
17. Keratins 8 and 18 are type II acute-phase responsive genes overexpressed in human liver disease. PMID: 24930437
18. In human failing myocardium, where TNF-alpha expression is upregulated, K8/K18 were also ectopically expressed. PMID: 26280121
19. Human KRT8 variants promote acetaminophen induced hepatotoxicity in mouse models. PMID: 25963979
20. Syndecan-1 is involved in the morphogenesis of the developing tooth crown and cervical loops, and in conjunction with CK8 and vimentin, in the differentiation of preameloblasts and preodontoblasts. PMID: 25120060
21. K8 immunostaining of tissue from the lymph node metastasis allows for the identification of a subgroup of lymph node-positive breast cancer patients with a highly unfavorable outcome. PMID: 25724181
22. This marks the first instance where intestinal cells have been suggested to be functionally impaired by K8/K18 mutations. PMID: 24915158
23. The study indicates that Piwil2 plays a role in Fas-mediated apoptosis and can influence p53 phosphorylation in tumor cells, revealing a novel mechanism of Piwil2 in apoptosis, and supporting the notion that Piwil2 plays an active role in tumorigenesis. PMID: 25113562
24. An increased expression of cytokeratin 8 and weak expression of calponin in the tunica media of saphenous vein grafts may serve as useful markers of unfavorable long-term prognosis in CABG patients. PMID: 24338534
25. These data support the concept that CK8 is an important receptor for Pet on epithelial cells for initiating its cytotoxic effects. PMID: 24327340
26. Parkin may inhibit cell growth, at least in part, by decreasing RPSA expression and inducing phosphorylation of cytokeratin 8/18. PMID: 23990477
27. These findings, along with the emerging role of cell surface CK8 in cancer metastasis, may imply a dual strategy for tumor cell survival in the host. PMID: 24183726
28. CK8 up-regulation might play a functional role in HCV infection and pathogenesis, and its ectopic expression induces apoptosis of SMMC7721 cells. PMID: 24115814
29. This is the first study to demonstrate a down-regulated CK8 expression and the percentage of CK8-positive cell clusters in IDD based on multiple lines of evidence. PMID: 23801880
30. Compressive loads resulted in phosphorylation and disassembly of CK8 in nucleus pulposus cells. PMID: 24166186
31. A conserved rod domain phosphotyrosine that is targeted by the phosphatase PTP1B promotes keratin 8 protein insolubility and filament organization. PMID: 24003221
32. These results indicate the role of K8/18 in modulating invasion in breast cancer. PMID: 23341946
33. Report keratin 8 expression in breast papillomas and papillary carcinoma. PMID: 23327593
34. K8/18 expression can influence the phenotype of epithelial cancer cells at a transcriptional level and supports the hypothesis that keratins play an active role in cancer progression. PMID: 23449973
35. Keratin variants are expressed in a low percentage of patients with alcoholic cirrhosis and do not influence hepatocellular carcinoma development. PMID: 23078008
36. There is aberrant expression of CK8 in dysplasia, oral submucous fibrosis, and oral squamous cell carcinoma, suggesting CK8 as a surrogate marker of malignant transformation. PMID: 22677743
37. K8 acetylation at Lys-207, a highly conserved residue among type II keratins, is up-regulated upon hyperglycemia and down-regulated by SIRT2. PMID: 23358244
38. A key K8/K18 regulation of glucose metabolism in normal and cancerous hepatic cells through differential modulations of mitochondrial hexokinase status and insulin-mediated signaling. PMID: 23164509
39. Fibroblasts prepared from different types of malignant tumors stimulate expression of luminal marker keratin 8. PMID: 22270320
40. Keratin filaments were assembled from recombinant keratin proteins 8 (K8) and 18 (K18) in the presence of divalent ions (Mg(2+)). PMID: 22853896
41. Keratin 8 phosphorylation regulates keratin reorganization and migration of epithelial tumor cells. PMID: 22344252
42. Results demonstrate that K8 is present on the cell surface of transformed prostate cancer cell lines, and K8 increased the activity of plasmin approximately fivefold over a 48-h period. K8 also enhanced the plasmin-mediated proteolysis of vitronectin. PMID: 22354665
43. In patients with hemochromatosis, intronic but not exonic K8/K18 variants associate with liver fibrosis development. PMID: 22412904
44. A moderate positive correlation between proliferation and keratin 8 expression in neoplastic epithelial cells has been observed. PMID: 22379894
45. Previously undescribed K8 variants are associated with cryptogenic hepatitis in a German cohort of patients, potentially predisposing carriers to the development of liver disease. PMID: 22419260
46. Loss of keratin 8 phosphorylation leads to increased oral squamous cell carcinoma progression. PMID: 22114688
47. Findings suggest that CK8 is unsuitable for early diagnosis of tongue squamous cell carcinoma. PMID: 21705376
48. The mild KRT8 allele is associated with CFTR mediated residual chloride secretion among F508del-CFTR homozygotes. PMID: 21548936
49. The study demonstrates the strong expression of CK8 in limbal epithelial basal cells, which is maintained during the differentiation and migration of the limbal cells toward the central corneal epithelium. PMID: 20926822
50. Clumping factor B is capable of binding cytokeratin 8 during infection. PMID: 20817646

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HGNC: 6446

OMIM: 148060

KEGG: hsa:3856

STRING: 9606.ENSP00000293308

UniGene: Hs.533782