Phospho-NFATC3 (S165) Antibody
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Product Specs
Buffer
Liquid in PBS containing 50% glycerol, 0.5% BSA, and 0.02% sodium azide.
Form
Liquid
Lead Time
Generally, we can ship the products within 1-3 business days after receiving your order. Delivery time may vary depending on the purchasing method or location. For specific delivery times, please consult your local distributor.
Synonyms
C80703 antibody; cytoplasmic 3 antibody; D8Ertd281e antibody; NF AT4 antibody; NF ATc3 antibody; NF-AT4 antibody; NF-ATc3 antibody; NFAC3_HUMAN antibody; NFAT4 antibody; NFATc3 antibody; NFATx antibody; Nuclear factor of activated T cells, cytoplasmic 3 antibody; nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 3 antibody; Nuclear factor of activated T-cells antibody; T cell transcription factor NFAT4 antibody; T-cell transcription factor NFAT4 antibody
Target Names
Uniprot No.
Target Background
Function
Phospho-NFATC3 (S165) Antibody acts as a regulator of transcriptional activation. It plays a role in the inducible expression of cytokine genes in T-cells, particularly in the induction of IL-2. Alongside NFATC4, it is involved in embryonic heart development.
Gene References Into Functions
- MicroRNA-214 regulates immunity-related genes in bovine mammary epithelial cells by targeting NFATc3 and TRA PMID: 28627449
- NFATc3 initially induces the expression of its interacting partner FosB before forming the heterodimeric NFATc3-FosB transcription factor complex. This complex then binds to the proximal AP-1 site in the TF gene promoter, leading to the activation of TF expression. PMID: 28724635
- VIP inhibits NFAT nuclear translocation in primary human pulmonary artery smooth muscle cells (PASMC). Early activation of NFATc3 in IPF patients may contribute to disease progression, and the increased VIP expression could be a protective compensatory mechanism. PMID: 28125639
- The transcription factor NFATC3 interacts with IRF7 and synergistically enhances IRF7-mediated IFN expression in Plasmacytoid dendritic cells. PMID: 27697837
- Calcineurin, along with its upstream molecule calpain 2 and its downstream effector NFAT-c3, might contribute to the development of atrial fibrillation in patients with heart valve disease and diabetes. PMID: 27123462
- NFATc3 interacts in a SUMO-dependent manner with Trim17, an E3 ubiquitin ligase essential for neuronal apoptosis. PMID: 25215946
- Nuclear NF-AT3 and NF-AT4 are involved in atrial structural remodeling, and PICP and TGF-beta1 levels may serve as sensitive serum biomarkers for estimating atrial structural remodeling with atrial fibrillation. PMID: 25422138
- Microvesicles from tumor cells transfer TrpC5 to endothelial cells, inducing the expression of P-glycoprotein by activating the transcription factor NFATc3. PMID: 24582564
- The AP-1 and NFAT4 complex promotes miR-23a expression. PMID: 23929433
- The closely related transcription factors NFAT1 and NFAT4 exhibit distinct nuclear localization dynamics in response to cell stimulation. PMID: 23219532
- NFATc3 undergoes rapid dephosphorylation and nuclear translocation, completing within 20 minutes, while NFATc4 remains phosphorylated and localized to the cytosol. PMID: 22977251
- Abeta-activated NFAT4 proteins are associated with astrocytic BACE1 gene expression via direct interaction with the BACE1 promoter region. PMID: 22846573
- NFAT4 and NF-kappaB interact at the KB element to cooperatively activate both human polyomavirus JC early and late transcription and viral DNA replication. PMID: 22749879
- NFATc3 is specifically required for IL2 and cyclooxygenase-2 (COX2) gene expression in T cells and for T-cell proliferation. NFATc3 also regulates COX2 in endothelial cells. PMID: 21642596
- NFAT exhibits transactivation activity and plays a role in inducing differentiation of CD4(+)CD8(+) T cells. PMID: 11997392
- NFAT and thyroid transcription factor-1 contribute to regulating transcription of the surfactant protein D gene. PMID: 15173172
- NFATc3 is negatively regulated by class II histone deacetylases through the DnaJ (heat shock protein-40) superfamily member Mrj. PMID: 16260608
- Calcium signaling and the activation of NFAT in glial cells are required for JC Virus infection of the CNS. PMID: 17035332
- CHP2 plays a role in tumorigenesis and as an activator of the calcineurin/NFAT signaling pathway. PMID: 18815128
Database Links
Subcellular Location
Cytoplasm. Nucleus. Note=Cytoplasmic for the phosphorylated form and nuclear after activation that is controlled by calcineurin-mediated dephosphorylation. Rapid nuclear exit of NFATC is thought to be one mechanism by which cells distinguish between sustained and transient calcium signals. The subcellular localization of NFATC plays a key role in the regulation of gene transcription.
Tissue Specificity
Isoform 1 is predominantly expressed in thymus and is also found in peripheral blood leukocytes and kidney. Isoform 2 is predominantly expressed in skeletal muscle and is also found in thymus, kidney, testis, spleen, prostate, ovary, small intestine, hear
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