Phospho-PLD1 (S561) Antibody

1. Lower PLD1 expression and higher ICAT expression have been significantly associated with improved survival rates in colorectal cancer patients. PMID: 28939743
2. Research findings highlight an unexpected role for alpha-synuclein in PLD regulation: downregulation of PLD1 may be an early mechanism in the initial stages of neurodegeneration triggered by wild-type alpha-synuclein. PMID: 29571767
3. A study has shown significant downregulation of PLD1 in all multiple sclerosis (MS) patients compared to controls. PMID: 28229303
4. Simultaneously high expression of PLD1 and Sp1 is associated with a poor prognosis for patients with pancreatic ductal adenocarcinoma. PMID: 27713167
5. In the hearts of PLD1 knockout mice, researchers observed marked tricuspid regurgitation, right atrial enlargement, and increased flow velocity. Additionally, the leaflets of the pulmonic valve were found to be narrowed and thickened. These findings support a role for PLD1 in normal heart valvulogenesis. PMID: 27799408
6. PLD1, through its regulation of protein kinase C-epsilon, protects retinal pigment epithelium cells from damage induced by lipopolysaccharide. PMID: 27793751
7. Research findings suggest a novel role of PLD1 in maintaining cancer cell survival during metabolic stress. PMID: 27809301
8. PLD expression in high-grade serous ovarian carcinoma may play a role in mediating progression to effusions and chemoresistance. PMID: 28087476
9. Inhibition of phosphatidylcholine-specific phospholipase C downregulates CXCR4 expression and interferes with proliferation, invasion, and glycolysis in glioma cells. PMID: 28423060
10. Data suggest that PLD expression in allergic disorders, including asthma pathogenesis, may have a variety of potential roles. PMID: 26335962
11. Research findings reveal a novel role of the PLD1-pleckstrin homology domain as a positive regulator of endocytosis and establish a link between PLD1 and HIF-1alpha in the EGFR endocytosis pathway. PMID: 26680696
12. MicroRNA-638 inhibits cell proliferation by targeting phospholipase D1 in human gastric carcinoma. PMID: 26250158
13. These observations define a novel function of PLD1 as a previously unrecognized HIF-1alpha regulator. PMID: 25361009
14. The impact of polyunsaturated fatty acid (PUFA) supplementation on phospholipase D (PLD) trafficking and activity in mast cells has been investigated. PMID: 23698760
15. Overexpression of PED/PEA-15 is sufficient to block hydrogen peroxide-induced apoptosis in Ins-1E cells through a PLD-1 mediated mechanism. PMID: 25489735
16. Insufficient PLD1 activity, and the associated changes in phospholipid compositions within membranes, may be a contributing factor to impaired autophagic processes and protein accumulation in Lewy body diseases. PMID: 24632948
17. Results indicate distinctive roles of phospholipase D isoforms PLD1 and PLD2 in pathological conditions in the retinal pigment epithelium (RPE). PMID: 25172550
18. Phospholipase D is involved in the formation of Golgi-associated clathrin-coated vesicles in human parotid duct cells. PMID: 24618697
19. PLCdelta1 possesses tumor-suppressive functions in colorectal cancer through induction of E-cadherin. PMID: 25197077
20. Downregulation of Chk-alpha with siRNA increased PLD1 expression, while downregulation of PLD1 increased Chk-alpha expression. PMID: 24556997
21. Ectopic expression of PLD1 or PLD2 in human glioma U87 cells resulted in increased expression of hypoxia-inducible factor-1alpha protein. PMID: 25523098
22. PLD1 plays crucial roles in cancer cell growth and metastasis. PMID: 24990946
23. PlD1 and PLD2 are implicated in cell migration, invasion, and metastasis. PMID: 24103483
24. Suppression of PLD1 activity prevents FAM83B-mediated transformation. PMID: 23912460
25. This study indicates that PLD1 plays a role in regulating type I collagen accumulation through the induction of autophagy. PMID: 24802400
26. Chemokine unresponsiveness in chronic lymphocytic leukemia lymphocytes is attributed to the failure of Arf1/phospholipase D1-mediated translocation of Rap1 to the plasma membrane for GTP loading. This may be a specific characteristic of anergy induced by DNA antigens. PMID: 23804711
27. The direct association of PLD1 with the carboxy-terminal tail domain of the 5-HT2A receptor selectively disrupts its PLD signaling pathway. PMID: 23314176
28. These results suggest that protein kinase D (PKD) is downstream of PLD and propose that PKD is one of the mechanisms by which PLD promotes aldosterone production in response to AngII in adrenal glomerulosa cells. PMID: 23178798
29. The hydrophobic amino acids involved in the interdomain association of PLD1 are crucial for its vesicular localization and influence its nuclear localization. PMID: 22824913
30. PLD1 in the tumor environment promotes tumor growth and metastasis. PMID: 23131846
31. Diacylglycerol stimulates acrosomal exocytosis by feeding into a PKC- and PLD1-dependent positive loop that continuously supplies phosphatidylinositol 4,5-bisphosphate. PMID: 22609963
32. PLD acts as a significant regulator in Bcl-2 expression by activating STAT3, involving the phosphorylation of Ser727 through the PLA(2)/G(i)/ERK1/2, RhoA/ROCK/p38 MAPK, and Rac1/p38 MAPK pathways. PMID: 22504301
33. Stx1B and Stx2B induce acute VWF secretion in a PLD1-dependent manner, but they differentially modulate PKCalpha, RhoA, and ADP-ribosylation factor 6. PMID: 22718838
34. Studies suggest that phospholipase D (PLD) acts as a mediator of nutrients to mTORC1. PMID: 22457329
35. Amino acids stimulate PLD1 translocation to the lysosomal region, where mTORC1 activation occurs in an hVps34-dependent manner. This translocation is essential for mTORC1 activation. PMID: 22024166
36. Activation of PLD1 contributes to IL-15-mediated osteoclastogenesis via the MAPKs and NF-kappaB signaling pathways in rheumatoid synovial fibroblasts. PMID: 21620893
37. Host cell PLD1 and PLD2 accompany A. fumigatus conidia during internalization. PMID: 21760893
38. Results indicate that PLD activation is required for PMA-stimulated respiratory burst. PMID: 20158570
39. The activation with overexpression of components of the mTORC2-PLD1 pathway in ULMS and, to a lesser extent, in STUMP provides insights into their tumorigenic mechanisms. PMID: 21326806
40. The PLD1/PA-mTORC2 signal pathway is overactivated in endometrial carcinomas. PMID: 21228924
41. Nuclear localization of phospholipase D1 mediates the activation of nuclear protein kinase C(alpha) and extracellular signal-regulated kinase signaling pathways. PMID: 21113078
42. AMPK-mediated PLD1 activation is required for (14)C-glucose uptake through ERK stimulation. PMID: 20231899
43. Data show that formylpeptides induce sequential activation of AKT, ERK1/2, and PLD, representing a novel signaling pathway. PMID: 20693286
44. PLD isozyme acts as a novel transcriptional target and positive feedback regulator of Wnt signaling, promoting Wnt-driven anchorage-independent growth of colorectal cancer cells. PMID: 20711340
45. Data demonstrate a functional relationship between phospholipases D1/2 and MAP kinases in the human HeLa carcinoma cell line. PMID: 19896495
46. Platelet-derived growth factor-induced PLD1 expression via NFkappaB may enhance the invasiveness of breast cancer cells. PMID: 20188462
47. Upregulated phospholipase D1 is associated with a positive feedback loop to reinforce the Wnt/beta-catenin/TCF signaling in neoplasms. PMID: 20442281
48. This research reveals a novel regulatory mechanism in PLD1 functioning, particularly in the context of subcellular trafficking between different membrane compartments. PMID: 20189990
49. Temporal regulation of EGFR endocytosis is achieved by auto-regulatory PLD1, which senses receptor activation and triggers the translocation of AP2 near the activated receptor. PMID: 19763255
50. Alpha-synuclein interacts with phospholipase D isozymes and inhibits pervanadate-induced phospholipase D activation in human embryonic kidney-293 cells. PMID: 11821392

Show More

Hide All

HGNC: 9067

OMIM: 212093

KEGG: hsa:5337

STRING: 9606.ENSP00000342793

UniGene: Hs.382865