Phospho-TENC1 (Y483) Antibody
Shipped with Ice Packs 
In Stock 
Product Specs
Buffer
The antibody is provided as a liquid solution in phosphate-buffered saline (PBS) containing 50% glycerol, 0.5% bovine serum albumin (BSA), and 0.02% sodium azide.
Form
Liquid
Lead Time
Typically, we can ship the products within 1-3 business days after receiving your order. The delivery time may vary depending on the specific purchasing method or location. Please consult your local distributors for precise delivery timeframes.
Synonyms
C1 domain containing phosphatase and tensin homolog antibody; C1 domain-containing phosphatase and tensin homolog antibody; C1 TEN antibody; C1-TEN antibody; C1TEN antibody; DKFZp686D13244 antibody; FLJ16320 antibody; KIAA1075 antibody; TENC 1 antibody; TENC1 antibody; TENC1_HUMAN antibody; Tensin 2 antibody; Tensin like C1 domain containing phosphatase antibody; Tensin-2 antibody; Tensin-like C1 domain-containing phosphatase antibody; TNS2 antibody
Target Names
TNS2
Uniprot No.
Target Background
Function
Tensin 1 (TENC1) is a tyrosine-protein phosphatase that plays a crucial role in regulating various cellular processes, including cell motility, proliferation, and muscle response to insulin. Under catabolic conditions, TENC1 dephosphorylates insulin receptor substrate 1 (IRS1) in muscles, leading to its degradation and muscle atrophy. This dephosphorylation negatively regulates the activation of the PI3K-AKT pathway, a significant signaling pathway involved in cell growth and survival.
Gene References Into Functions
- Patients with low TENS2 expression exhibited poor relapse-free survival rates for breast and lung cancers. These findings strongly indicate a role of Tensin 2 in suppressing cell transformation and reducing tumorigenicity. PMID: 27203214
- p62 expression increased while C1-Ten protein decreased during muscle differentiation, supporting a role for p62 as a physiological regulator of C1-Ten. PMID: 25101860
- Pulldown studies in human cells using Myc-tagged Tensin 2 constructs revealed that DISC1 specifically interacts with the C-terminal PTB domain of Tensin 2 in a phosphorylation-independent manner. PMID: 23233134
- Research has identified tensin 2 as a Syk-binding protein. PMID: 22019427
- This study reports complete chemical shift assignments of the SH2 domain of human tensin 2 determined by triple resonance experiments. PMID: 21461930
- Tensin 2 is a critical mediator in the TPO/c-Mpl pathway and exerts a positive influence on cellular growth, at least partially through its impact on the PI3K/Akt signaling pathway. PMID: 21527831
- The Tensin 2 SH2 domain was found to interact with both nonphosphorylated ligand (DLC-1) and phosphorylated ligand. PMID: 21765928
- Beyond regulating cytoskeletal dynamics, Tensin 2 influences phosphoinositide-Akt signaling through its PTPase domain. PMID: 20678486
- Data suggests that the interaction between START-GAP1 and tensin 2 occurs in a PTB domain-dependent manner. PMID: 19895840
- Differential proteolytic cleavage of Tensin 2 can liberate domains with distinct localizations and functions, which has implications for the role of Tensins in cancer cell survival and motility. PMID: 19747564
- Interaction of Axl receptor tyrosine kinase with C1-TEN. PMID: 12470648
- C1 domain-containing phosphatase and TENsin homologue (C1-TEN) appears to be a novel intracellular phosphatase that negatively regulates the Akt/Protein kinase B signaling cascade. PMID: 15817639
- Variant 3 significantly promoted the cell growth and motility of HCC cells; clonal transfectants of variant 3 were more closely packed and resulted in a higher saturation density than in the control vector transfectants. PMID: 17006924
- Tensins may represent a novel group of metastasis suppressors in the kidney, the loss of which leads to increased tumor cell motility and subsequent metastasis. PMID: 19194507
- DLC1 interaction with tensin 2 through this novel focal adhesion binding site contributes to the growth-suppressive activity of DLC1. PMID: 19440389
Database Links
Subcellular Location
Cell junction, focal adhesion. Cell membrane; Peripheral membrane protein; Cytoplasmic side.
Tissue Specificity
Detected in heart, kidney, brain, thymus, spleen, liver, placenta, lung, skeletal muscle and small intestine.
Quick Inquiry
Personal Email Detected
Please use an institutional or corporate email address for inquiries. Personal email accounts ( such as Gmail, Yahoo, and Outlook) are not accepted. *
