Phospho-TK1 (Ser13) Antibody

1. STK1p is a potential proliferating biomarker for early detection of individuals at risk of developing or already having pre-malignancies or diseases associated with the risk process of malignancy. PMID: 29689706
2. Research indicates that serum thymidine kinase 1 (S-TK) activity may serve as a valuable parameter for monitoring the effectiveness of neoadjuvant therapy (nTx). PMID: 29189449
3. Our study presents the first evidence suggesting that serum TK1 activity as early as 2 weeks following CDK4/6 inhibitors is strongly correlated with tumor cell proliferation response in patients with early-stage HR+ breast cancer. PMID: 29162134
4. TK1 might play a role in the development and progression of pancreatic ductal adenocarcinoma (PDAC) by regulating cell proliferation. PMID: 29266545
5. The detection of TK1 in combination with cytokeratin-19 fragment (CYFRA21-1), CEA or NSE enhanced the diagnostic value of TK1 for lung squamous cell carcinoma, adenocarcinoma and small cell lung cancer, respectively. PMID: 29247745
6. These findings have implications for understanding the mechanism by which Fhit regulates TK1 mRNA and, more broadly, for its modulation of multiple functions as a tumor suppressor/genome caretaker. PMID: 28093273
7. Results suggest that positive expression of CK19 mRNA and TK1 protein is closely associated with poor prognosis in advanced gastrointestinal cancer. PMID: 27625087
8. Although TK1 expression was an independent prognostic factor for relapse, but not for survival, TK1 is a more informative expression than Ki-67 for local invasion, relapse, and overall survival rates. Therefore, when TK1 is combined with MDACC grading, pTNM staging, and lymph node metastasis, immunohistochemical determination of TK1 expression can improve the overall prediction of prognosis in patients with ovarian cancer. PMID: 28651488
9. Data indicate that the median thymidine kinase (TK1) levels found in sera from breast cancer patients with T1 to T4 stage disease were 0.31, 0.46, 0.47, and 0.55 ng/ml, and these levels significantly differed from healthy controls. PMID: 27079872
10. STK1 is a reliable biomarker for identifying individuals with malignant tumors in cancer screening. PMID: 27002755
11. Serum Thymidine Kinase 1 Activity Following Nephrectomy for Renal Cell Carcinoma and Radiofrequency Ablation of Metastases to Lung and Liver PMID: 27069161
12. TK1 expression is significantly different in invasive urothelial carcinoma and benign urothelium, highlighting its potential as a diagnostic marker. PMID: 26231311
13. Protein expression of BIRC5, TK1, and TOP2A in malignant peripheral nerve sheath tumors - A prognostic test after surgical resection. PMID: 25769404
14. High Thymidine Kinase expression is associated with adenocarcinoma in Non-small Cell Lung Cancer. PMID: 25921119
15. These results demonstrate that there are differences in the specific activities and the subunit compositions of STK1 in hematological malignancies compared with breast and prostate cancer. PMID: 25881026
16. A regression analysis showed that only TK1 levels were significant (relative risk (RR)=1.03 for each unit, confidence interval (CI)=1-1.05; p=0.015) for diagnosing a true transformation. PMID: 25964590
17. We suggest that a chip including DPYD, TYMS, TYMP, TK1, and TK2 genes is a potential tool to predict response in locoregional advanced rectal cancer (LARC) following fluoropyrimidine-based chemoradiotherapy (CCRT). PMID: 24455740
18. Nuclear TK1 expression in early grade cervical intraepithelial neoplasia predicts risk for progression to malignancy. PMID: 23693054
19. 3'-deoxy-3'-[18F]-fluorothymidine (18F-FLT) kinetics correlates with thymidine kinase-1 expression and cell proliferation in newly diagnosed gliomas. PMID: 23229746
20. The magnitude of maximum fluorodeoxyglucose uptake in primary tumors and the serum TK1 level in patients with metastatic non-small cell lung cancer (NSCLC) were found to be independent prognostic predictors of overall survival. PMID: 23116493
21. Increased serum level of thymidine kinase 1 correlates with metastatic site in patients with malignant melanoma. PMID: 23179401
22. Results suggest that the serum TK1 protein differs from cellular or recombinant forms, is more active in high molecular weight complexes, and is sensitive to reducing agents. PMID: 22741536
23. Data suggest that serum thymidine kinase 1 (TK1) levels may help to refine risk assessment in the modern immunotherapy era. PMID: 22263569
24. The crystal structure of the T163S-mutated HuTK1 reveals a less ordered conformation of the ligand thymidine triphosphate compared with the wild-type structure. PMID: 22385435
25. TK1 may be involved in poor survival in patients with pT1 of lung adenocarcinoma. PMID: 22143937
26. Frequencies of polymorphic mutations in HIV-1 (subtype B) were compared between patients detected with the 69 insertion (n = 17), Q151M (n = 29), >/=2 thymidine analogue mutations (TAM) 1 (n = 400) or >/=2 TAM 2 (n = 249). PMID: 22027876
27. Data demonstrate that the Flt3L/TK gene therapeutic approach can induce systemic immunological memory capable of recognizing a brain tumor neoantigen in a model of recurrent glioblastoma multiforme (GBM). PMID: 21505426
28. (18)F-FLT uptake and retention within cells may be influenced by a variety of still undetermined factors in addition to TK1 enzymatic activity. PMID: 21764789
29. Elevated serum thymidine kinase 1 is associated with pre/early cancerous progression. PMID: 21545220
30. High levels of HER2 and Ki-67 or TK1 expression correlate with increased tumor grades and tumor recurrence in meningiomas. PMID: 20450760
31. Serological thymidine kinase 1 is a useful marker for prognosis in patients with esophageal, cardial, and lung carcinomas. PMID: 20479645
32. Serum TK1 correlates to clinical stages and clinical reactions and monitors the effect of tumor therapies, not only in controlled clinical trials, but also in routine clinical settings. PMID: 20354751
33. Direct involvement of the G-quadruplex motif in transcription of TK1. PMID: 20849417
34. Nucleoside recognition mechanisms for TK1 and TK2 are very different. Nonpolar nucleosides are likely to be active in the nucleotide salvage pathway in human cells. PMID: 20560637
35. Results suggest that higher thymidine levels in TK- cells caused by defective thymidine salvage to dTTP protect against UV irradiation. PMID: 20544518
36. The expression of TK1 in tumor tissues correlated to pathological stages and clinical grades of carcinomas (ca) of esophagus, lung, and in premalignancy of breast ductal ca. STK1p could monitor the outcome of tumor therapy. PMID: 20544519
37. More dTTP synthesis via TK1 takes place after genotoxic insults in tumor cells, improving DNA repair during G(2) arrest. PMID: 20554529
38. Cell cycle regulation of TK1 in normal tubule cells differs from that in other types of normal and malignant renal cells. PMID: 19957115
39. Thymidine kinase-1 and thymidylate synthase expression was markedly different between cancer types, suggesting that response to TAS-102 may differ. PMID: 20372850
40. Thymidine kinase has a role in progression of lung cancer. PMID: 20592392
41. TK1 in serum may possess a reference value in the evaluation of treatment and prognosis of non-Hodgkin's lymphoma following chemotherapy. PMID: 20140744
42. The TK1 model presented supports both K and k positive cooperativity. Three-parameter mass action models can and should replace the 3-parameter Hill model. PMID: 20003201
43. TK1 gene expression together with TS, TP, and DPD gene expression may play important roles in influencing the malignant behavior of epithelial ovarian cancer. PMID: 11992400
44. Mutation analysis in the coding sequence of thymidine kinase 1 in breast and colorectal cancer. PMID: 12699056
45. Long-term treatment of H9 human lymphoid cells in the presence of dideoxycytidine down-regulated TK1 gene expression and reduced the expression and activity of TK in resistant cells. PMID: 14659972
46. The enzymatic function at the G2/M phase of TK1 depends on its quaternary structure. PMID: 14697231
47. Activation of the APC/C-Cdh1 complex during mitotic exit controls the timing of TK1 destruction. PMID: 14701726
48. Activity of thymidine kinase, thymidine phosphorylase, and thymidilate synthase in human cancer xenografts to investigate the contribution of these enzymes to the sensitivity of TAS-102. PMID: 14719072
49. The importance of valine 106 for the structure and function of TK1. PMID: 15153115
50. Activation of TK1 may be critical to modulate the radiation-induced cell death and cell cycle progression in irradiated K562 cells. PMID: 15353126

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HGNC: 11830

OMIM: 188300

KEGG: hsa:7083

STRING: 9606.ENSP00000301634

UniGene: Hs.515122