PIAS1 Antibody

1. Rad18, independent of its ubiquitin ligase activity, promotes DNA polymerase eta SUMOylation by facilitating its interaction with its SUMO ligase PIAS1. This interaction is essential for DNA polymerase eta function at challenging replication loci. PMID: 27811911
2. PIAS1 acts as a key regulator of Epstein-Barr Virus lytic replication, inhibiting transcription factors involved in lytic gene expression. PMID: 29262325
3. Research suggests that PIAS1 is a positive regulator of MYC. PMID: 27239040
4. PIAS1 has been identified as a prognostic biomarker in breast cancer. PMID: 28493978
5. PIAS1 is associated with poor survival in prostate cancer and acts as a positive feedback regulator of AR signaling, enhancing AR stabilization. PMID: 26257066
6. Overexpression of PIAS1 has been shown to exacerbate mutant Huntingtin-associated phenotypes and aberrant protein accumulation. PMID: 27146268
7. HBs protein-induced hPIAS1 transcription is dependent on TAL1, E47, MYOG, NFI, and MAPK signal pathways. PMID: 27276529
8. PIAS1 has been identified as a constituent PML-NB antiviral protein, suggesting a role for SUMO ligases in promyelocytic leukemia nuclear body mediated intrinsic immunity. PMID: 27099310
9. PIAS1 enhances p300 recruitment to c-Myb-bound sites through interaction with both proteins. Its E3 activity further amplifies this coactivation. PMID: 27032383
10. Research indicates that apocrine breast cancer and prostate cancer cells share a core AR cistrome and target gene signature linked to cancer cell growth. PIAS1 plays a similar coregulatory role for AR in both cancer cell types. PMID: 26219822
11. c-Myc is targeted for degradation in a SUMOylation-dependent manner, regulated by PIAS1, SENP7, and RNF4. PMID: 25895136
12. PIAS1 interacts with TRF2 and mediates its sumoylation, acting as a molecular switch that controls the level of TRF2 at telomeres. PMID: 26450775
13. The expression of SENP8, SAE1, PIAS1, PIAS2, and ZMIZ1 is dysregulated in a majority of PTC tissues, potentially contributing to the PTC phenotype. PMID: 26403403
14. Data suggest that necdin suppresses PIAS1 by inhibiting its SUMO E3 ligase activity and promoting its ubiquitin-dependent degradation. PMID: 24911587
15. Evidence suggests that PIAS1 is crucial for the survival of both parental and docetaxel-resistant prostate cancer cells. PMID: 25474038
16. Elevated PIAS1 expression has been observed in breast tumor samples. PMID: 24586797
17. PIAS1 is the E3 ligase responsible for SUMOylation of HMGN2. PMID: 24872413
18. Further studies revealed that PIAS1 interacts with IRF3 and inhibits the DNA binding activity of IRF3. PMID: 24036127
19. Levels of STAT1 and/or the protein expression of its negative regulators, PIAS1 and SOCS3, may be a good predictor of hepatitis C virus response to therapy. PMID: 23472246
20. Smad2 and PIAS1 proteins were significantly upregulated in the presence of zinc, resulting in dramatically increased interactions between Smad2/4 and PIAS1. PMID: 24052079
21. Phosphorylation of serine residues adjacent to the PIAS1 SUMO-interacting motif promotes the formation of the non-covalent PIAS1.SUMO.UBC9 ternary complex. PMID: 24174529
22. Research suggests that the pro-apoptotic protein Daxx specifically interacts with one or more substrates SUMOylated by PIAS1. This interaction leads to apoptosis following UV irradiation. PMID: 22976298
23. Data suggests that PIAS1 may function as a tumor suppressor to regulate gastric cancer cell metastasis by targeting the MAPK signaling pathway. PMID: 22972521
24. MAPK-activated protein kinase-2 limits endothelial inflammation through the PIAS1 S522 phosphorylation-mediated increase in PIAS1 transrepression and SUMO ligase activity. PMID: 23202365
25. PIAS1 is a SUMO ligase for GATA4 that differentially regulates GATA4 transcriptional activity, independent of SUMO ligase activity and GATA4 sumoylation. PMID: 22539995
26. Research reveals a significant new role for PIAS1 in regulating cell proliferation in prostate cancer. PMID: 22449952
27. PIAS1 negatively regulates ubiquitination of Msx1 homeoprotein, independent of its SUMO ligase activity. PMID: 21717107
28. There are differences in PIAS3 expression across various stages of gastric precancerous conditions/lesions and GC, suggesting a close relationship between expression reduction or loss of PIAS3 and gastric tumorigenesis. PMID: 21925039
29. PIAS1 determines the level of JNK activity in human endometrial stromal cells, couples ROS signaling to the SUMO pathway, and promotes oxidative cell death. PMID: 21676946
30. PIAS1 is a common partner for two cancer-related nuclear factors, c-Myb and FLASH. PMID: 21338522
31. Research shows that regulation of SATB1 sumoylation and caspase cleavage is controlled by SATB1 phosphorylation, specifically, PIAS1 interaction with SATB1 is inhibited by phosphorylation. PMID: 20351170
32. Protein inhibitor of activated Stat1 (PIAS1) interacts with the tetramerization and C-terminal regulatory domains of p53 in yeast two-hybrid analyses. PMID: 11788578
33. Protein inhibitors of activated STAT resemble scaffold attachment factors and function as interacting nuclear receptor coregulators. PMID: 11877418
34. PIAS1 and PIASxalpha modulate AR-dependent transactivation, at least partially attributed to their SUMO-E3 activity toward AR. PMID: 12177000
35. PIAS1 plays a role in the sumoylation of MDM2 in the cell nucleus. PMID: 12393906
36. PIAS1 strongly stimulates sumoylation of STAT1 at Lys703, suggesting a negative regulatory function for sumoylation. PMID: 12855578
37. PIAS1 interacts with the N-terminal domain of the human mineralocorticoid receptor, repressing its ligand-dependent transcription. PMID: 14500761
38. The three-dimensional structure and its binding duality of PIAS1 are discussed in conjunction with its biological functions as a SUMO ligase. PMID: 15133049
39. PIAS1 acts as a checkpoint regulator, affecting exit from G1 and G2 through sumoylation of p73. PMID: 15572666
40. PIAS1 interacts with DNA cross-link repair SNM1A in nuclear focus formation. PMID: 15572677
41. Results suggest that recombinant human interleukin-12 upregulates STAT-1 expression in a dose-dependent manner. PMID: 15901746
42. PIAS1 modulates transcriptional activation of smooth muscle cells marker genes through cooperative interactions with both serum response factor and class I basic helix-loop-helix proteins. PMID: 16135793
43. Pias1 binds to and sumoylates metabotropic glutamate receptor 8. PMID: 16144832
44. Research demonstrates that MEF2A undergoes sumoylation primarily at a single lysine residue (K395) both in vitro and in vivo. The nuclear E3 ligase, PIAS1, promotes sumoylation of MEF2A. PMID: 16563226
45. PIAS1 is required for the appropriate localization and retention of Msx1 at the nuclear periphery in myoblast cells. PMID: 16600910
46. TGF-beta rapidly suppresses IFN-gamma-driven STAT1 signaling by reducing DNA binding through promotion of STAT1--PIAS1 interactions, rather than inhibition of STAT1 activation. PMID: 17371985
47. PIASy collaborates with PIAS1 to down-regulate the specificity and magnitude of NF-kappa B/STAT1-mediated gene activation. PMID: 17606919
48. Research indicates that HCV NS3/4a can block the Jak-Stat signaling pathway at the stage of Stat-1 serine 727 phosphorylation. PMID: 18190974
49. PIAS1 staining of colon cancer tissue microarrays indicated a strong correlation of normal colon cells and adenomas with high expression of both PIAS1 and IRF-1. PMID: 19288270
50. PIAS1 exhibits a novel function in the induction of JNK-dependent apoptosis, separate from its previously known inhibitory activity in STAT-mediated gene activation. PMID: 11451946

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HGNC: 2752

OMIM: 603566

KEGG: hsa:8554

STRING: 9606.ENSP00000249636

UniGene: Hs.162458