unc-11 Antibody
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In Stock 
Product Specs
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Lead Time
Made-to-order (14-16 weeks)
Synonyms
unc-11 antibody; C32E8.10 antibody; Phosphatidylinositol-binding clathrin assembly protein unc-11 antibody; AP180-like adaptor protein antibody; Uncoordinated protein 11 antibody
Target Names
unc-11
Uniprot No.
Target Background
Function
UNC-11 antibody is a protein that functions in recruiting clathrin and adaptor protein complex 2 (AP2) to cell membranes. This process is essential for the formation of coated pits and clathrin-vesicle assembly. UNC-11 may play a crucial role in regulating the amount of membrane recycled by controlling the size of the clathrin cage. It is also involved in AP2-dependent clathrin-mediated endocytosis at the neuromuscular junction. Furthermore, UNC-11 is essential for the efficient targeting of the synaptic vesicle protein synaptobrevin.
Database Links
KEGG: cel:CELE_C32E8.10
UniGene: Cel.16650
Protein Families
PICALM/SNAP91 family
Subcellular Location
Membrane, clathrin-coated pit. Golgi apparatus. Cytoplasmic vesicle, clathrin-coated vesicle. Note=Colocalized with clathrin in the Golgi area.
Tissue Specificity
High levels in the nervous system and at lower levels in other tissues. In neurons, enriched at presynaptic terminals and is also present in cell bodies.
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