Customize PRR1 Antibody

Description

PRR1 Protein Overview

Gene: TMEM37 (synonym: PRR1)
Protein family: PMP-22/EMP/MP20
Molecular weight: ~20.9 kDa (canonical isoform)
Localization: Cell membrane, notably expressed in kidney, duodenum, and hematopoietic tissues .

PRR1 facilitates cell-cell adhesion in endothelial and epithelial tissues and is implicated in leukocyte interactions and cancer biology .

Role in Acute Myeloid Leukemia (AML)

A study analyzing PRR1 expression in 55 AML patients revealed:

Parameter	PRR1-Positive Cases (%)	Prognostic Association
Cytogenetic risk groups	73% (favorable) vs. 25% (poor)	Higher PRR1 correlates with better relapse-free survival
FAB subtypes	M3 (100%), M4 (85%)	Lower expression in M0/M5 subtypes

PRR1 antibodies (clone R1.302.12) were used in flow cytometry to quantify PRR1 on bone marrow blasts .
Patients with >78% PRR1+ cells showed prolonged survival, suggesting PRR1 as a potential prognostic marker .

Clinical and Research Applications

Diagnostics: Detects PRR1 in prostate, kidney, and cancer tissues .
Therapeutic potential: Antibodies like PR1 (targeting a prostate-specific antigen) show promise for targeted therapies, though PRR1-specific therapies remain exploratory .
Mechanistic studies: Elucidates PRR1’s role in thrombin signaling and endothelial dysfunction .

Limitations and Future Directions

Cross-reactivity: Some antibodies may bind paralogs (e.g., PRR2) .
Functional studies: Limited data on PRR1 signaling pathways in non-hematopoietic tissues .

Product Specs

Buffer

Preservative: 0.03% ProClin 300; Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Lead Time

14-16 weeks (made-to-order)

Synonyms

PRR1 antibody; PLR1 antibody; At1g32100 antibody; F3C3.10 antibody; Pinoresinol reductase 1 antibody; AtPrR1; antibody; +)-pinoresinol reductase antibody; EC 1.23.1.1; antibody; -)-pinoresinol reductase antibody; EC 1.23.1.3 antibody; Pinoresinol-lariciresinol reductase 1 antibody; AtPLR1 antibody

Target Names

PRR1

Uniprot No.

Q9FVQ6

Target Background

Function

PRR1 is a reductase enzyme involved in lignan biosynthesis. Unlike many pinoresinol reductases, which can reduce both pinoresinol and lariciresinol, PRR1 exhibits a strong substrate preference for pinoresinol. It is active on both (+)- and (-)-pinoresinol isomers. The catalytic mechanism involves the abstraction of the 4R-hydride from the NADPH cofactor.

Gene References Into Functions

PMID: 25107662, Demonstrates an association between the lignan biosynthetic enzyme encoded by PrR1 and secondary cell wall biosynthesis in fiber cells., .
PMID: 18347017, Reports that AtPrR1 (encoded by At1g32100) efficiently reduced both (+)- and (-)-pinoresinol to (+)- and (-)-lariciresinol, exhibiting comparable k_cat/K_m values., .

Database Links

KEGG: ath:AT1G32100

STRING: 3702.AT1G32100.1

UniGene: At.28661

Protein Families

NmrA-type oxidoreductase family, Isoflavone reductase subfamily

Tissue Specificity

Expressed in roots and stems.

Quick Inquiry

Personal Email Detected

Please use an institutional or corporate email address for inquiries. Personal email accounts ( such as Gmail, Yahoo, and Outlook) are not accepted. *

Name*

Email*

Phone

Country

Source

Quantity&Size*

Product Name

Message

PRR1 Antibody