PIP4K2C Antibody, FITC conjugated
Description
Key Attributes of PIP4K2C Antibody, FITC Conjugated
Example Product Codes:
Functional Use Cases
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Immunofluorescence (IF): Localizes PIP4K2C in cellular compartments, such as autophagosomes or membranes, to study its role in vesicular trafficking and autophagy .
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Western Blot (WB): Detects PIP4K2C at ~47–50 kDa in human kidney and brain tissues, validating knockout models or kinase inhibition studies .
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ELISA: Quantifies PIP4K2C expression levels in serum or lysates for biomarker analysis .
Role of PIP4K2C in Disease Pathways
While the FITC-conjugated antibody itself is a detection tool, studies using PIP4K2C-targeting reagents highlight its biological significance:
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Immune Modulation: PIP4K2C knockout mice exhibit hyperactive immune responses and autoimmunity, suggesting its role in regulating mTORC1 signaling and immune tolerance .
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Viral Infection: PIP4K2C binds SARS-CoV-2 nonstructural protein NSP6, impairing autophagic flux. Inhibitors like RMC-113 reverse this effect, demonstrating therapeutic potential .
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Cancer Immunotherapy: Degradation of PIP4K2C enhances phagocytosis of tumor cells and synergizes with anti-PD-1 therapies in colorectal cancer models .
Performance Metrics
Product Specs
**Constituents:** 50% Glycerol, 0.01M PBS, pH 7.4
