pak-1 Antibody
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Product Specs
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Lead Time
Made-to-order (14-16 weeks)
Synonyms
pak-1 antibody; C09B8.7 antibody; Serine/threonine-protein kinase pak-1 antibody; EC 2.7.11.1 antibody; CePAK antibody; p21-activated kinase 1 antibody; PAK1 antibody
Target Names
pak-1
Uniprot No.
Target Background
Function
PAK-1, a key regulator of cytoskeletal dynamics, plays a crucial role in various developmental processes in C. elegans. In conjunction with CDC-42 and CED-10, PAK-1 facilitates hypodermal cell fusion, leading to embryonic body elongation. This process involves significant cytoskeletal reorganization. Additionally, PAK-1 exhibits redundancy with MAX-2 in guiding dorsal axons in ventral cord commissural motoneurons and directing P neuroblast migration. Acting downstream of Rho GTPases MIG-2 and CED-10, PAK-1 regulates these processes. Furthermore, PAK-1 is involved in orientating axonal growth of HSN neurons. During gonad morphogenesis, PAK-1, in collaboration with PIX-1 and GIT-1, participates in distal tip cell (DTC) migration and maintains their characteristic tapering morphology. Moreover, PAK-1 displays redundant function with MAX-2 in DTC-mediated gonad elongation guidance. PAK-1 may phosphorylate ML-4.
Gene References Into Functions
- The FOXO-Pak1 pathway has been demonstrated to regulate mammalian neuronal polarity. Our research indicates that the functions of FOXO and Pak1 in neuronal migration are likely conserved across species, from C. elegans to higher organisms. PMID: 23994474
- PAK1 promotes reproduction while simultaneously inactivating the HSP16.2 gene, leading to a shortened lifespan. PMID: 23524941
- Pak-1 interacts with Wnt signaling to regulate tissue polarity and gene expression. PMID: 23019370
- Exclusively PAK-1 functions within the GIT/PIX/PAK pathway independent of RAC/CDC42 GTPases. PMID: 19023419
Database Links
Protein Families
Protein kinase superfamily, STE Ser/Thr protein kinase family, STE20 subfamily
Subcellular Location
Cell membrane; Peripheral membrane protein. Cytoplasm. Cell projection, axon. Perikaryon.
Tissue Specificity
Specifically colocalized with cdc-42 and ced-10 at all hypodermal cell boundaries during embryo elongation throughout the second phase of embryogenesis. Expressed mainly in pharyngeal muscles, the CAN neurons, motor neurons in the ventral nerve cord, seve
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