PKD2L1 Antibody
Shipped with Ice Packs 
In Stock 
Product Specs
Buffer
PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. Stored at -20°C. Avoid freeze/thaw cycles.
Lead Time
Generally, we can ship your orders within 1-3 business days after receiving them. Delivery times may vary depending on the purchasing method or location. Please consult your local distributors for specific delivery details.
Synonyms
B830002B15 antibody; BC046386 antibody; PCL antibody; PK2L1 antibody; PK2L1_HUMAN antibody; PKD2L antibody; PKD2L1 antibody; PKDL antibody; Polycystic kidney disease 2 like 1 antibody; Polycystic kidney disease 2 like 1 protein antibody; Polycystic kidney disease 2-like 1 protein antibody; Polycystin L antibody; Polycystin-2 homolog antibody; Polycystin-2L1 antibody; Polycystin-L antibody; Polycystin-L1 antibody; Transient receptor potential cation channel subfamily P member 3 antibody; TRPP3 antibody
Target Names
PKD2L1
Uniprot No.
Target Background
Function
PKD2L1 is the pore-forming subunit of a heterotetrameric, non-selective cation channel. This channel is permeable to Ca2+. PKD2L1 is also the pore-forming subunit of a calcium-permeant ion channel formed by PKD1L2 and PKD1L1 in primary cilia. This channel regulates cilium calcium concentration, but does not impact cytoplasmic calcium concentration. The channel formed by PKD1L2 and PKD1L1 in primary cilia controls sonic hedgehog (SHH) signaling and GLI2 transcription. Additionally, PKD2L1 is the pore-forming subunit of a channel formed by PKD1L2 and PKD1L3, contributing to sour taste perception in gustatory cells. The heteromeric channel formed by PKD1L2 and PKD1L3 is activated by low pH, but only opens when the extracellular pH rises. This channel may play a role in the perception of carbonation taste. PKD2L1 may also participate in the sensory perception of water through a mechanism that activates the channel in response to salivary bicarbonate dilution and changes in salivary pH.
Gene References Into Functions
- The pore helix and transmembrane segment 6 of PKD2L1 are involved in both upper and lower-gate opening, adopting an open conformation. PMID: 29567962
- PKD2 and PKD1 genes are mutated in autosomal dominant polycystic kidney disease. PKD2 can form either a homomeric cation channel or a heteromeric complex with the PKD1 receptor. This complex is presumed to respond to ligands and/or mechanical stimuli. A recent study identified a two-residue hydrophobic gate in PKD2L1 and a single-residue hydrophobic gate in PKD2. PMID: 29899465
- Palmitoylation at Cys-38 and phosphorylation at Thr-39 independently regulate TRPP3 channel function. PMID: 27754867
- Research has identified C1 as the first PKD2L1 domain essential for both PKD2L1 trimerization and channel function. These findings suggest that PKD2L1 and PKD2L1/PKD1L3 channels share the PKD2L1 trimerization process. PMID: 25820328
- Trimerization may be critical for both homo- and potentially heteromeric assemblies of PKD2L1. PMID: 22193359
- A study demonstrated that human PKD2L plays a role in food preference behavior. PMID: 22794107
- Pkd2L1 is a novel target channel whose function is regulated by the versatile scaffolding protein RACK1. PMID: 22174419
- Despite the moderate sequence identity between C-terminal regulatory domains (CRDs) of PKD2 and PKD2L1, they both form trimers. This implies that trimeric organization of CRDs may be a common characteristic of all polycystin channels. PMID: 20408813
- The PKD2L1-PKD1L3 complex is involved in acid sensing in vivo. PMID: 20406802
- The calcium-binding EF-hand in polycystin-L is not a domain for channel activation and subsequent inactivation. PMID: 11959145
- Collectively, alpha-actinin not only anchors TRPP3 to the cytoskeleton but also up-regulates TRPP3 channel function. PMID: 17944866
Database Links
Protein Families
Polycystin family
Subcellular Location
Cell projection, cilium membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle.
Tissue Specificity
Detected in taste bud cells in fungiform papillae (at protein level). Ubiquitous. Expressed in adult heart, skeletal muscle, brain, spleen, testis, retina and liver. Isoform 4 appears to be expressed only in transformed lymphoblasts.
Quick Inquiry
Personal Email Detected
Please use an institutional or corporate email address for inquiries. Personal email accounts ( such as Gmail, Yahoo, and Outlook) are not accepted. *
