PLA2G4B Antibody
Shipped with Ice Packs 
In Stock 
Product Specs
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Lead Time
Generally, we can ship products within 1-3 business days of receiving your order. Delivery times may vary depending on the purchasing method or location. Please consult your local distributor for specific delivery times.
Synonyms
PLA2G4B antibody; Cytosolic phospholipase A2 beta antibody; cPLA2-beta antibody; EC 3.1.1.4 antibody; Phospholipase A2 group IVB antibody
Target Names
PLA2G4B
Uniprot No.
Target Background
Function
PLA2G4B is a calcium-dependent phospholipase A1 and A2, and lysophospholipase, potentially playing a role in membrane phospholipid remodeling. It functions as a calcium-dependent phospholipase A2 and lysophospholipase. PLA2G4B cleaves the ester bond of the fatty acyl group attached to the sn-2 position of phosphatidylethanolamines, producing lysophospholipids that may be involved in deacylation-reacylation cycles. While it hydrolyzes lysophosphatidylcholines with low efficiency, it is inefficient toward phosphatidylcholines.
Additionally, PLA2G4B acts as a calcium-dependent phospholipase A1 and A2, and lysophospholipase. It cleaves the ester bond of the fatty acyl group attached to the sn-1 or sn-2 position of diacyl phospholipids (phospholipase A1 and A2 activity, respectively), producing lysophospholipids that may be used in deacylation-reacylation cycles. PLA2G4B can further hydrolyze lysophospholipids, enabling complete deacylation. However, it exhibits no activity toward alkylacyl phospholipids.
Additionally, PLA2G4B acts as a calcium-dependent phospholipase A1 and A2, and lysophospholipase. It cleaves the ester bond of the fatty acyl group attached to the sn-1 or sn-2 position of diacyl phospholipids (phospholipase A1 and A2 activity, respectively), producing lysophospholipids that may be used in deacylation-reacylation cycles. PLA2G4B can further hydrolyze lysophospholipids, enabling complete deacylation. However, it exhibits no activity toward alkylacyl phospholipids.
Gene References Into Functions
- JMJD7-PLA2G4B may serve as an important therapeutic target and prognostic marker for the development and progression of head and neck squamous cell carcinoma. PMID: 28030848
- TLR2 cooperates with MyD88, PI3K, and Rac1 in lipoteichoic acid-induced cPLA2/COX-2-dependent airway inflammatory responses. PMID: 20167866
- Observational study of gene-disease association. (HuGE Navigator) PMID: 19913121
- Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) PMID: 20628086
- Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) PMID: 20056178
Database Links
Subcellular Location
[Isoform 3]: Cytoplasm, cytosol. Mitochondrion membrane; Peripheral membrane protein. Early endosome membrane; Peripheral membrane protein.; [Isoform 5]: Cytoplasm, cytosol.
Tissue Specificity
Widely expressed. Expressed at higher level in brain, heart, liver, cerebellum and pancreas.
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