plac8.2 Antibody
Description
Introduction to PLAC8 Antibodies
PLAC8 (placenta-specific 8) is a multifunctional protein implicated in immune regulation, tumorigenesis, and cellular differentiation. Antibodies targeting PLAC8 enable researchers to study its expression, localization, and mechanistic roles in diseases such as cancer, sepsis, and autoimmune disorders. While the term "plac8.2 Antibody" is not explicitly defined in scientific literature, available data suggests it may refer to a specific clone or formulation of PLAC8-targeting antibodies. This article synthesizes findings from diverse sources to outline key features, applications, and research insights related to PLAC8 antibodies.
Key Features of PLAC8 Antibodies
PLAC8 antibodies are polyclonal or monoclonal reagents validated for applications including Western blot (WB), immunohistochemistry (IHC), immunofluorescence (IF), and ELISA. Below are specifications for widely used PLAC8 antibodies:
Role in Immune Regulation
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Sepsis and Monocyte Function: PLAC8 modulates ERK signaling in monocytes, influencing cytokine production (TNF-α, IL-6) and cell proliferation during sepsis .
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T Cell Regulation: PLAC8 suppresses IFNγ production in Th1 CD4+ T cells, impacting anti-pathogen responses .
Cancer Biology
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Tumor Microenvironment: PLAC8 expression correlates with immune cell infiltration (CD8+ T cells, macrophages) in clear cell renal cell carcinoma (ccRCC) and predicts immunotherapy response .
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Therapeutic Target: PLAC8 promotes chemotherapy resistance and metastasis in cancers, making it a focus for antibody-based therapeutic strategies .
Developmental Biology
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Trophoblast Function: PLAC8 is a marker for interstitial extravillous trophoblast cells (iEVTs), critical for placental invasion and vascular remodeling .
Applications of PLAC8 Antibodies
Challenges and Future Directions
Product Specs
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
