egl-8 Antibody

Preservative: 0.03% Proclin 300; Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Liquid

14-16 weeks (made-to-order)

egl-8 antibody; B0348.4 antibody; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta egl-8 antibody; EC 3.1.4.11 antibody; Egg-laying defective protein 8 antibody; Phosphoinositide phospholipase C-beta egl-8 antibody; Phospholipase C-beta egl-8 antibody; PLC-beta egl-8 antibody

egl-8

G5EBH0

The egl-8 antibody targets a protein that mediates the production of diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3), crucial second messenger molecules in intracellular signaling cascades. This protein is essential for modulating neuronal activity in the nervous system, facilitating synaptic transmission at neuromuscular junctions by regulating acetylcholine release from motor neurons and influencing locomotion. Furthermore, it plays a role in oviposition, defecation, axon regeneration following injury, and male mating behavior (specifically spicule insertion and sperm transfer). Its function also extends to regulating avoidance behavior in response to tactile stimuli, achieved by triggering calcium transients via IP3-mediated activation of the itr-1 receptor in ASH sensory neurons. Additionally, it is required for the expression of the antimicrobial peptide nlp-29 in response to fungal infection, acting through DAG-mediated activation of tpa-1. Finally, during embryogenesis, it potentially contributes to epidermal morphogenesis in conjunction with plc-1.

STRING: 6239.B0348.4b

UniGene: Cel.6072

Perikaryon. Cell projection, axon. Cell junction, synapse. Cell junction, adherens junction.

Expressed in most or all neurons with high expression in the head and tail ganglia and low expression in the motor neurons of the ventral cord. Expressed in the intestine (at protein level). In males, expressed in vas deferens, spicule protractor muscles,