PLCG1 (Ab-783) Antibody

1. Research suggests that FGFR3 with mutations found in SADDAN (but not FGFR3 with mutations found in TDII) affects cytoskeleton organization in chondrocytes by inducing tyrosine hyperphosphorylation of paxillin; binding of FGFR3 to PLCG1 appears to be involved. (FGFR3 = fibroblast growth factor receptor 3; SADDAN = Severe Achondroplasia with Developmental Delay and Acanthosis Nigricans; TDII = Thanatophoric Dysplasia type II) PMID: 29242050
2. PLCgamma2 plays a critical role in Ca(2+) flux in HCECs stimulated by A. fumigatus hyphae. Syk acts upstream of PLCgamma2 in the Dectin-1 signaling pathway. PMID: 30005593
3. A previously unrecognized role for PLC-gamma1 in the positive regulation of Zap-70 and T-cell receptor tyrosine phosphorylation has been identified. Conversely, PLC-gamma1 negatively regulated the phosphorylation of SLP-76-associated proteins, including previously established Lck substrate phosphorylation sites within this complex. PMID: 28644030
4. Syk-induced signals in bone marrow stromal cell lines are mediated by phospholipase C gamma1 (PLCgamma1) in osteogenesis and PLCgamma2 in adipogenesis. PMID: 28786489
5. PLCG1, along with ITGA4, is regulated by miR-30b in clinical samples of coronary artery cells from coronary atherosclerosis patients. PMID: 27464494
6. The central biological role of the novel IL-2-R/Lck/PLCgamma/PKCtheta;/alphaPIX/Rac1/PYGM signaling pathway is directly related to the control of fundamental cellular processes such as T cell migration and proliferation. PMID: 27519475
7. LAT and phospholipase C-gamma dephosphorylation by SHP-1 inhibits natural killer cell cytotoxicity. PMID: 27221712
8. The products of PLC-gamma activity mediate the innate immune response by regulating respiratory burst, phagocytosis, cell adhesion, and cell migration. (Review) PMID: 27707630
9. 1,25(OH)2D3 indirectly modulates the differentiation of Treg/Th17 cells by affecting the VDR/PLC-gamma1/TGF-beta1 pathway. These findings suggest that administering 1,25(OH)2D3 supplements may be a beneficial treatment for organ transplantation recipients. PMID: 28926770
10. Results show that PLCgamma-1 activation enhanced skin cell transformation. PMID: 28574619
11. These results suggest that immobilized EGF increases collective keratinocyte displacement via an increase in single-cell migration persistence resulting from altered EGFR trafficking and PLCgamma1 activation. PMID: 27025961
12. High FLC gamma expression is associated with radioresistance in glioblastoma. PMID: 26896280
13. High PLC gamma expression is associated with breast cancer. PMID: 28112359
14. We show that the decrease in PI(4,5)P2 level under non-stimulated conditions inhibits PTEN activity leading to the aberrant activation of the oncoprotein Akt. As well as defining a novel mechanism of Akt phosphorylation with important therapeutic consequences, we also demonstrate that differential expression levels of FGFR2, Plc11, and Grb2 correlate with patient survival. PMID: 26212011
15. The PLCgamma-1 signaling plays an important role in the H1N1-induced inflammatory responses. Our study suggests that targeting the PLCgamma-1 signaling is a potential antiviral therapy against H1N1 by inhibiting both viral replication and excessive inflammation. PMID: 27310357
16. These results indicate that PP1 is recruited to the extracellular calcium-dependent E-cadherin-catenin-PIP5K1a complex in the plasma membrane to activate PIP5K1a, which is required for PLC-g1 activation leading to keratinocyte differentiation. PMID: 27340655
17. FGFR1 dimers form a complex with its effector PLCgamma1. PMID: 26482290
18. High PLC gamma1 expression is associated with gastric adenocarcinoma. PMID: 26811493
19. Report PLCG1 genetic alterations in angiosarcomas. PMID: 26735859
20. Expression of PLC-gamma1 and PIKE positively correlated with the tumor differentiation of oral squamous cell carcinoma. PMID: 26464646
21. In a transgenic mouse model, PLCgamma1 is the dominant signaling effector by which activation of TrkB promotes epilepsy. PMID: 26481038
22. hsa-miR-665 and hsa-miR-95 were downregulated in GSRCC but upregulated in intestinal gastric adenocarcinoma, and the relatively differential expression of the miRNAs negatively controlling their target genes, GLI2 and PLCG1. PMID: 25964059
23. Results provide evidence that PTPRB and PLCG1 mutations are driving events in a subset of secondary angiosarcomas. PMID: 24795022
24. PLLG1 protein mutations are uncommon in cutaneous T-cell lymphomas. PMID: 25910029
25. PLCgamma1 is part of the molecular mechanism. PMID: 25491205
26. Recurrent presence of the PLCG1 S345F mutation is associated with nodal peripheral T-cell lymphomas. PMID: 25304611
27. The degradation of zonula occludens-1 (ZO-1), and claudin-2 exhibited a great dependence on the activation of the transient receptor potential melastatin (TRPM) 2 channel, phospholipase Cgamma1 (PLCgamma1) and the protein kinase Calpha (PKCalpha) signaling cascade. PMID: 23629676
28. Data from structural, genetic, and mechanistic studies on the role of PLCG1 in cell biology suggest that dysfunctional forms of PLCG1 are linked to immune disorders and cancer. [REVIEW] PMID: 25456276
29. This SOCS7 knockdown-attributed effect could be due to a precise anti-PLCg-1 role. PMID: 25162020
30. The activation of the gamma1 isoform of phospholipase C (PLCgamma1) is critical for pressure sensing in cerebral arteries and subsequent vasoconstriction. PMID: 24866019
31. These findings indicate that the PLCgamma1-R707Q mutation causes constitutive activation of PLCgamma1 and may represent an alternative way of activation of KDR/PLCg1 signaling besides KDR activation in angiosarcomas. PMID: 25252913
32. Results reveal that PLCG1 is genetically altered in a significant portion of cutaneous T-cell lymphomas. PMID: 24706664
33. A portion of PLC-gamma1 phosphorylated on tyrosine 783 is not found at LAT-containing clusters but instead is located at TCR-containing clusters. PMID: 24412752
34. Extracellular K(+) concentration regulated the levels of activated PLC-gamma1, chromosome X, and carbachol-stimulated intracellular Ca(2+) mobilization in human endothelial cells. PMID: 24785188
35. Increased proliferative and survival mechanisms in cutaneous T-cell lymphoma may partially depend on the acquisition of somatic mutations in PLCG1 and other genes that are essential for normal T-cell differentiation. PMID: 24497536
36. PLCG1, a signal transducer of tyrosine kinases, encoded a recurrent, likely activating p.Arg707Gln missense variant in 3 of 34 cases of angiosarcoma. PMID: 24633157
37. Phospholipase C gamma1 plays a key role in cell migration and invasion. [review] PMID: 23925006
38. PLCgamma1 signaling is the dominant pathway in promoting limbic epileptogenesis. PMID: 24502564
39. Metastatic outcome can be dictated by the constitutive competition between Grb2 and Plcgamma1 for the phosphorylation-independent binding site on FGFR2. PMID: 24440983
40. Study showed that PLC-gamma directly binds c-Src through its SH2 domains, and this interaction is necessary for carbachol-mediated inhibition of NHE3 activity in Caco-2/BBe/NHE3 cells. PMID: 23703528
41. PLC-gamma1 is highly expressed in the brain and participates in neuronal cell functions mediated by neurotrophins. (Review) PMID: 23063587
42. High expression of PLCgamma1, and of its activated forms, is associated with a worse clinical outcome. PMID: 22847294
43. The role of four domains of human PLCG1 defined by structural and biochemical investigation. PMID: 23063561
44. Data indicate that Akt expression was up-regulated with high glucose and insulin in both cell lines, whereas PLCgamma expression was enhanced in colon cancer cells only. PMID: 22554284
45. Analysis of two distinct mechanisms by which phospholipase C-gamma1 mediates epidermal growth factor-induced keratinocyte migration and proliferation. PMID: 22749651
46. T cell receptor (TCR)-mediated proliferation is impaired in PLCgamma1/PLCgamma2 double-deficient T cells compared with PLCgamma1 single-deficient T cells. PMID: 22837484
47. The oncogenic truncation of this region elicits conformational changes that interfere with the Vav1-mediated activation of PLCgamma1 and that inhibit calcium mobilization. PMID: 22474331
48. Report the interplay of HER2/HER3/PI3K and EGFR/HER2/PLC-gamma1 signaling in breast cancer cell migration and dissemination. PMID: 22262199
49. Translocation of PLC-gamma 1 to the cell membrane and the associated calcium signal were enhanced only in mast cells responding to EP3 prostaglandin E2 receptor agonist sulprostone. PMID: 21798286
50. Our approach, which is applicable to any set of interval scale traits that is heritable and exhibits evidence of phenotypic clustering, identified three new loci in or near APOC1, BRAP, and PLCG1, which were associated with multiple phenotype domains. PMID: 22022282

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HGNC: 9065

OMIM: 172420

KEGG: hsa:5335

STRING: 9606.ENSP00000244007

UniGene: Hs.268177