PLCG2 (Ab-753) Antibody

1. Studies have found that mutations or polymorphisms in two putative calcium-regulated domains of PLCG2 are associated with ibrutinib-resistant chronic lymphocytic leukemia (CLL). This finding adds to the evidence suggesting complex regulatory shifts in the PLCG2 protein, which may occur during the development of resistance. PMID: 28366935
2. Research indicates a novel mechanism of PLCgamma activation with unique thermodynamic features, assigning a new regulatory role to its spPH domain. PMID: 27196803
3. Data suggest that protein-altering changes in the PLCG2, ABI3, and TREM2 genes, highly expressed in microglia, may play a significant role in Alzheimer's disease. These findings highlight an immune-related protein-protein interaction network in this condition. PMID: 28714976
4. Ocular manifestations of phospholipase-Cgamma2-associated antibody deficiency and immune dysregulation are linked to mutations in the PLC[gamma]2 gene. These mutations result in aberrant function of immune cells and overproduction of interleukin-1 [beta] (IL-1[beta]). PMID: 27442322
5. Mutations R665W and L845F are considered allomorphic rather than hypermorphic mutations of PLCG2. Rerouting of transmembrane signals from the B-cell receptor (BCR) converging on PLCgamma2 through Rac in ibrutinib-resistant CLL cells may offer novel drug treatment strategies to overcome ibrutinib resistance mediated by PLCG2 mutations or prevent its development in ibrutinib-treated CLL patients. PMID: 27542411
6. Research reveals that phospholipase Cgamma2 (PLCgamma2) is strongly expressed in B-cell non-Hodgkin lymphoma, particularly in a large subset of diffuse large B-cell lymphoma (DLBCL). PMID: 25012946
7. Characterization of the effect of the missense point-mutation at R665W in PLCG2 on signaling mechanisms of ibrutinib resistance in chronic lymphocytic leukemia cells. PMID: 25972157
8. Amarogentin inhibits platelet activation by blocking the PLC gamma2-PKC cascade and MAPK pathway. PMID: 24868545
9. A PLCG2 missense mutation has been identified as a risk factor in the development of steroid-sensitive nephrotic syndrome in childhood. PMID: 25349203
10. The autoinhibitory C-terminal SH2 domain of phospholipase C-gamma2 plays a crucial role in stabilizing B cell receptor signalosome assembly. PMID: 25227611
11. The relationship between the upstream tyrosine kinase SYK and its target, PLCgamma2, is highly predictive and sufficient to distinguish chronic lymphocytic leukemia from healthy controls. PMID: 24489640
12. Single-nucleotide polymorphisms in the PLCG2 gene have been associated with an increased risk of breast cancer following menopausal hormone replacement therapy. PMID: 24080446
13. Researchers have identified three distinct mutations in PLCgamma2 in two patients exhibiting resistance to ibrutinib. PMID: 24869598
14. Early Ca(2+) fluxing serves as a feed-forward signal amplification mechanism by promoting the anchoring of the PLCgamma2 C2 domain to phospho-SLP65. PMID: 24166973
15. BANK1 and BLK have roles in B-cell signaling through phospholipase C gamma 2. PMID: 23555801
16. Down-regulation of the PLCgamma2-beta-catenin pathway occurs in both mice and humans, leading to myeloid-derived suppressor cells-mediated tumor expansion. PMID: 24127488
17. No associations were found between treatment response and the expression levels of Lyn, Syk, PLCgamma2, and ERK. PMID: 23039362
18. Overexpression of the altered p.Ser707Tyr protein and ex vivo experiments using leukocytes from affected individuals clearly showed enhanced PLCgamma2 activity. PMID: 23000145
19. PLCgamma2 participates in T cell receptor (TCR) signal transduction and plays a role in T cell selection in a transgenic mouse model. PMID: 22837484
20. Genomic deletions in PLCG2 cause a gain of PLCgamma(2) function, leading to signaling abnormalities in multiple leukocyte subsets and a phenotype encompassing both excessive and deficient immune function. PMID: 22236196
21. Data indicate a role for PLCgamma2 and Ca(2+) signaling through the modulation of MEK/ERK in IL3/GM-csf stimulated human hematopoietic stem/progenitor cells. PMID: 21506110
22. Rac2 binding in the absence of lipid surfaces was unable to activate phospholipase C gamma 2. PMID: 21245382
23. SYK, along with phospholipase Cgamma2, may serve as potential biomarkers to predict dasatinib therapeutic response in patients. PMID: 20068106
24. Research suggests that bile acid reflux present in patients with Barrett's esophagus may increase reactive oxygen species production and cell proliferation through the activation of PI-PLCgamma2, ERK2 MAP kinase, and NADPH oxidase NOX5-S, contributing to the development of esophageal adenocarcinoma. PMID: 20086178
25. RTX treatment results in a time-dependent inhibition of the BCR-signaling cascade involving Lyn, Syk, PLC gamma 2, Akt, and ERK, as well as calcium mobilization. PMID: 19965664
26. The collagen receptor glycoprotein VI and alphaIIbbeta3 trigger distinct patterns of receptor signaling in platelets, leading to tyrosine phosphorylation of PLCgamma2 (integrin alphaiibbeta3). PMID: 12049640
27. Two tyrosine residues play a regulatory role in the activity of PLCgamma2. PMID: 12181444
28. Researchers have successfully cloned the full-length cDNA for human PLCgamma2 and expressed it in E. coli using the expression vector pT5T. PMID: 12359094
29. PLCG2 plays a signaling role in platelet glycoprotein Ib alpha calcium flux and cytoskeletal reorganization. PMID: 12813055
30. In gastric cancer, the protein translocation of PLCgamma2 and PKCalpha is a critical event in the process of apoptosis induction. PMID: 14606067
31. PLC-gamma2 undergoes phosphorylation on Y753, Y759, and Y1217 in response to engagement of the B-cell receptor. PMID: 15509800
32. PLCgamma2 is present in the majority of mediastinal B cell lymphomas. PMID: 15744341
33. A novel mechanism of PLCgamma(2) activation by Rac GTPases has been proposed. This mechanism does not involve protein tyrosine phosphorylation or PI3K-mediated generation of PtdInsP(3). PMID: 16172125
34. Downstream of JAK2, leptin-activated intracellular mediators and pathways have been identified, including phosphatidylinositol-3 kinase, phospholipase Cgamma2, and protein kinase C, as well as the p38 MAP kinase-phospholipase A(2) axis. PMID: 18000612
35. Plasmacytoid dendritic cells express a signalosome consisting of Lyn, Syk, Btk, Slp65 (Blnk), and PLCgamma2. Triggering CD303 leads to tyrosine phosphorylation of Syk, Slp65, PLCgamma2, and cytoskeletal proteins. PMID: 18022864
36. Rac regulates its effector phospholipase Cgamma2 through interaction with a split pleckstrin homology domain. PMID: 18728011

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HGNC: 9066

OMIM: 600220

KEGG: hsa:5336

STRING: 9606.ENSP00000352336

UniGene: Hs.372303