Function
PLDGAMMA2 is an enzyme that hydrolyzes glycerol-phospholipids at the terminal phosphodiesteric bond, generating phosphatidic acids (PA). It plays a significant role in diverse cellular processes, including phytohormone action, vesicular trafficking, secretion, cytoskeletal arrangement, meiosis, tumor promotion, pathogenesis, membrane deterioration, and senescence. While PLDGAMMA2 can utilize phosphatidylserine as a substrate, it exhibits a preference for ethanolamine-containing lipids. Notably, the enzyme can utilize phosphatidylcholine (PC) as a substrate in the presence of phosphatidylethanolamine (PE) and PIP2. PLDGAMMA2 is implicated in membrane lipid modulation under aluminum (Al) stress, and its elevated activity has been shown to negatively impact plant tolerance to Al.
Subcellular Location
Cytoplasm. Membrane; Peripheral membrane protein. Note=Found mainly associated with intracellular membranes but also with mitochondrial membranes, nuclei and clathrin-coated vesicles. Not found in chloroplast.
Tissue Specificity
Highly expressed in roots and flowers, moderately in stems, leaves and seedlings and low in siliques. Not detected in seeds.