PLEKHA3 Antibody
Shipped with Ice Packs 
In Stock 
Product Specs
Buffer
PBS containing 0.1% Sodium Azide, 50% Glycerol, pH 7.3. Store at -20°C. Avoid repeated freeze-thaw cycles.
Lead Time
Typically, we can ship the products within 1-3 business days after receiving your order. Delivery times may vary depending on the purchase method or location. Please consult your local distributors for specific delivery timelines.
Synonyms
PLEKHA3 antibody; FAPP1 antibody; Pleckstrin homology domain-containing family A member 3 antibody; PH domain-containing family A member 3 antibody; Phosphatidylinositol-four-phosphate adapter protein 1 antibody; FAPP-1 antibody; Phosphoinositol 4-phosphate adapter protein 1 antibody
Target Names
PLEKHA3
Uniprot No.
Target Background
Function
FAPP1 plays a critical role in regulating vesicular cargo transport from the trans-Golgi network (TGN) to the plasma membrane. It modulates Golgi phosphatidylinositol 4-phosphate (PtdIns(4)P) levels and activates the PtdIns(4)P phosphatase activity of SACM1L upon binding PtdIns(4)P in a 'trans' configuration. FAPP1 exhibits a preference for binding to PtdIns(4)P. Additionally, it negatively regulates APOB secretion from hepatocytes.
Gene References Into Functions
- Binding sites on Fapp1 protein for Arf1 and phosphatidylinositol-4-phosphate minimally overlap. PMID: 24462251
- This study reports the complete (1)H, (13)C and (15)N resonance assignments of the FAPP1-PH in its free state and those induced by PtdIns(4)P or detergent micelles. PMID: 21298564
- This research elucidates the molecular basis of phosphatidylinositol 4-phosphate and ARF1 GTPase recognition by the FAPP1 pleckstrin homology (PH) domain. PMID: 21454700
- The micelle-bound structure of the FAPP1 pleckstrin homology domain reveals how its prominent wedge independently tubulates Golgi membranes by leaflet penetration. PMID: 20300118
- Data demonstrate that FAPP1 and 2 are essential components of a phosphatidylinositol 4-phosphate- and ADP-ribosylation factor-regulated machinery that controls the generation of constitutive post-Golgi carriers. PMID: 15107860
Database Links
Subcellular Location
Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein.
Tissue Specificity
Widely expressed.
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