plk-2 Antibody
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Product Specs
Buffer
**Preservative:** 0.03% Proclin 300
**Constituents:** 50% Glycerol, 0.01M PBS, pH 7.4
**Constituents:** 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Lead Time
Made-to-order (14-16 weeks)
Synonyms
plk-2 antibody; Y71F9B.7 antibody; Serine/threonine-protein kinase plk-2 antibody; EC 2.7.11.21 antibody; Polo-like kinase 2 antibody
Target Names
plk-2
Uniprot No.
Target Background
Function
PLK-2 is a serine/threonine-protein kinase that plays a crucial role in oogenesis. It facilitates chromosome pairing and synapsis by promoting the recruitment and attachment of meiotic chromosomes to the nuclear envelope during prophase. This kinase also promotes the localization of brc-1 to the short arm of homologous chromosomes during meiotic prophase I. Furthermore, it regulates the formation of sun-1 patches along the nuclear envelope. In response to chromosomal asynapsis, PLK-2 promotes meiotic nuclei apoptosis. It plays a redundant role with plk-1 in establishing cell polarity downstream of mex-5 and mex-6 during the first embryonic cell divisions. PLK-2 is involved in nicotinic acetylcholine receptor-mediated sensitivity to nicotine, but not levamisole. It also regulates motility.
Gene References Into Functions
- Studies have shown that SYP-4 phosphorylation is dependent on Polo-like kinases PLK-1/2. A proposed model suggests that Polo-like kinases recognize crossover designation and phosphorylate SYP-4, stabilizing the synaptonemal complex and making chromosomes less susceptible to further double-strand break formation. PMID: 28346135
- Research indicates that CHK-2 promotes pairing and synapsis by phosphorylating a family of zinc finger proteins that bind to specialized regions on each chromosome known as pairing centers, priming their recruitment of the Polo-like kinase PLK-2. PMID: 26506311
- Polo kinases, via their polo box domains, bind to and regulate the activity of two key polarity proteins, MEX-5 and MEX-6. PMID: 18199581
Database Links
Protein Families
Protein kinase superfamily, Ser/Thr protein kinase family, CDC5/Polo subfamily
Subcellular Location
Nucleus. Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Chromosome, centromere, kinetochore. Chromosome.
Tissue Specificity
Expressed in oocytes.
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