parp-1 Antibody
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In Stock 
Product Specs
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Lead Time
Made-to-order (14-16 weeks)
Synonyms
parp-1 antibody; pme-1 antibody; Y71F9AL.18Poly [ADP-ribose] polymerase 1 antibody; EC 2.4.2.30 antibody; Poly ADP-ribose metabolism enzyme 1 antibody; Protein poly-ADP-ribosyltransferase parp-1 antibody; EC 2.4.2.- antibody
Target Names
parp-1
Uniprot No.
Target Background
Function
Poly[ADP-ribose] polymerase (PARP-1) is an enzyme that modifies various nuclear proteins through a post-translational modification called poly(ADP-ribosyl)ation. This modification is synthesized in response to DNA damage and serves as a crucial step in the detection and signaling pathway leading to DNA strand break repair and programmed cell death. PARP-1 plays a vital role in safeguarding the genome against mutations.
Gene References Into Functions
- Inhibition of PME-1, a PARP-1 related enzyme, decreases embryonic survival rate in irradiated worms. PMID: 15923155
Database Links
Subcellular Location
Nucleus.
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