PMEI9 Antibody

Proteinase Inhibitor 9 (PI9/SERPINB9) Antibody

(Closest match to "PMEI9" based on nomenclature similarities)

Overview

Proteinase Inhibitor 9 (PI9), also known as Serpin B9, is a human intracellular serine protease inhibitor that specifically neutralizes granzyme B, a protease critical for cytotoxic lymphocyte-mediated apoptosis . The monoclonal antibody PI9-17 (Clone PI9-17) is a well-characterized reagent targeting this protein.

Key Research Findings

Functional Significance

• Therapeutic Potential: PI9 overexpression in tumors is associated with immune evasion by inhibiting cytotoxic T-cell activity .

• Diagnostic Use: Serves as a biomarker in immunooncology studies to assess granzyme B pathways .

PMEL Antibody

(Potential nomenclature confusion with "PMEI9")

Overview

PMEL (Premelanosome Protein) is a melanocyte-specific glycoprotein involved in melanin synthesis. The polyclonal anti-PMEL antibody (e.g., HPA031649) targets epitopes in melanosomal matrix formation.

Analysis of Discrepancies

• Terminology Clarification: No "PMEI9" antibody exists in validated databases. The closest matches are PI9 (Serpin B9) and PMEL, both distinct targets.

• Potential Typographical Errors: "PMEI9" may conflate "PMEL" or "PI9," which are established antibody targets.

Recommendations for Further Research

1. Validate the intended target nomenclature through primary literature review.

2. Explore structural or functional homology between PI9/PMEL and the hypothetical "PMEI9."

3. Screen antibody repositories (e.g., Antibody Society, Thermo Fisher) using corrected terminology.