PGM2 Antibody
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Description
Key Features of PGM2 Antibodies
PGM2 antibodies are widely used in molecular biology and diagnostic research. Common characteristics include:
Mechanistic Insights
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Enzymatic Activity:
PGM2 converts ribose-1-phosphate to ribose-5-phosphate, critical for nucleotide salvage pathways . Its glucose isomerization activity supports glycolysis under fasting conditions . -
Non-Canonical Roles:
Nuclear translocation of PGM2 promotes DDR by stabilizing ROCK2 complexes, enabling DNA repair in cancer cells .
Clinical and Therapeutic Implications
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Prognostic Utility:
PGM2 overexpression is linked to shorter progression-free intervals (HR = 1.5; P = 0.003) in LUAD and chemoresistance in GBM . -
Therapeutic Targeting:
Inhibiting PGM2 or its partner ROCK2 synergizes with TMZ and anti-PD-L1 therapies, enhancing anti-tumor immunity in preclinical models .
Limitations and Future Directions
Product Specs
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Lead Time
Made-to-order (14-16 weeks)
Synonyms
At3g08590 antibody; F17O14.6 antibody; Probable 2,3-bisphosphoglycerate-independent phosphoglycerate mutase 2 antibody; BPG-independent PGAM 2 antibody; Phosphoglyceromutase 2 antibody; EC 5.4.2.12 antibody; PGAM-I 2 antibody
Target Names
PGM2
Uniprot No.
Target Background
Function
This antibody targets Phosphoglycerate Mutase 2 (PGM2), an enzyme that catalyzes the interconversion of 2-phosphoglycerate (2-PGA) and 3-phosphoglycerate (3-PGA). PGM2 is essential for guard cell function, playing a crucial role in stomatal movements regulated by blue light, abscisic acid (ABA), and low CO2 levels. Additionally, PGM2 is involved in fertility, particularly in pollen grain production.
Gene References Into Functions
- The genes At1g09780 and At3g08590, encoding PGM2 isoforms, have been shown to be critical for stomatal movement, vegetative growth, and pollen production. PMID: 21813794
Database Links
Protein Families
BPG-independent phosphoglycerate mutase family
Subcellular Location
Cytoplasm.
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