Function
PHS1 antibody is essential for accurate chromosome segregation during meiosis. It facilitates pairing between homologous chromosomes and plays a crucial role in the early stages of recombination. PHS1 ensures pairing fidelity and proper repair of meiotic DNA double-strand breaks. It regulates recombination and pairing of homologous chromosomes during meiotic prophase by controlling the transport of RAD50 from the cytoplasm to the nucleus. PHS1 may influence the pairing of gene-rich regions of the genome, rather than preventing pairing between repetitive DNA elements.