POLR2L Antibody

Molecular Target: POLR2L Protein

POLR2L (RNA Polymerase II Subunit L) encodes the RPABC5 subunit shared by RNA Polymerases I, II, and III . It plays a pivotal role in transcription by stabilizing Pol II’s structural integrity and facilitating interactions with other subunits (e.g., POLR2A, POLR2B) . Its zinc-binding domain is essential for enzymatic activity .

Transcriptional Regulation Studies

POLR2L antibodies enable tracking of Pol II dynamics during transcription stress. For example:

• DNA Damage Response: UV-induced transcription stress triggers proteasomal degradation of promoter-bound Pol II (P-Ser5 modified), detectable via POLR2L antibodies .

• Transcription Stalling: Antibodies identify Pol II accumulation at transcription-blocking lesions (TBLs), linking DNA repair to transcriptional arrest .

Cancer Research

POLR2L antibodies are critical in oncology studies:

Future Directions

• Mechanistic Studies: Elucidate POLR2L’s role in Pol III transcription and ribosomal RNA synthesis .

• Therapeutic Development: Validate POLR2L as a drug target in preclinical models of HCC and other malignancies .