ponA Antibody
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In Stock 
Product Specs
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Lead Time
Made-to-order (12-14 weeks)
Synonyms
Penicillin-binding protein 1A/1B (PBP1) [Includes: Penicillin-insensitive transglycosylase (EC 2.4.1.129) (Peptidoglycan TGase), Penicillin-sensitive transpeptidase (EC 3.4.16.4) (DD-transpeptidase)], ponA
Target Names
ponA
Uniprot No.
Target Background
Function
This antibody targets PonA, an enzyme involved in cell wall formation. Specifically, PonA facilitates the synthesis of cross-linked peptidoglycan from lipid intermediates. The enzyme possesses a penicillin-insensitive transglycosylase N-terminal domain responsible for the formation of linear glycan strands and a penicillin-sensitive transpeptidase C-terminal domain involved in cross-linking the peptide subunits. This process is likely essential for vegetative growth. PonA is thought to have a partially redundant function with PBP-2A (pbpA) during spore outgrowth.
Gene References Into Functions
- Elimination of PBP1 suppresses the lethality of an mreB null mutation. Abnormal localization of PBP1 is linked to polar cell wall bulging. PMID: 19192185
Database Links
KEGG: bsu:BSU22320
STRING: 224308.Bsubs1_010100012276
Protein Families
Glycosyltransferase 51 family; Transpeptidase family
Subcellular Location
Cell membrane; Single-pass type II membrane protein. Forespore inner membrane; Single-pass type II membrane protein. Note=Probably found all over the whole cell at low concentrations. Also localizes to the division site in vegetative cells.
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